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Literature DB >> 21697496

cis-Acting effects on RNA processing and Drosha cleavage prevent Epstein-Barr virus latency III BHRF1 expression.

Abstract

In Epstein-Barr virus (EBV) latency III (LTIII) infection, BHRF1 encodes three microRNAs (miRNAs). Herein we report that Drosha cleavage of LTIII BHRF1 RNA and cis-acting splicing effects inhibit splicing and inhibit BHRF1 RNA and protein expression. Evidence shown here supports the view that Drosha cleavage to generate mature miRNAs and cis-acting sequences that prevent mRNA maturation are independent processes that prevent LTIII BHRF1 expression in lymphoblastoid cell lines.

Entities: Gene Species

Mesh：

Substances：

Year: 2011 PMID： 21697496 PMCID： PMC3165800 DOI： 10.1128/JVI.00336-11

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

57 in total

1. The Epstein-Barr virus Bcl-2 homolog, BHRF1, blocks apoptosis by binding to a limited amount of Bim.

Authors: Anthony L Desbien; John W Kappler; Philippa Marrack
Journal: Proc Natl Acad Sci U S A Date: 2009-03-17 Impact factor: 11.205

2. Coupled RNA processing and transcription of intergenic primary microRNAs.

Authors: Monica Ballarino; Francesca Pagano; Erika Girardi; Mariangela Morlando; Davide Cacchiarelli; Marcella Marchioni; Nicholas J Proudfoot; Irene Bozzoni
Journal: Mol Cell Biol Date: 2009-08-10 Impact factor: 4.272

Review 3. Decoding the function of nuclear long non-coding RNAs.

Authors: Ling-Ling Chen; Gordon G Carmichael
Journal: Curr Opin Cell Biol Date: 2010-03-29 Impact factor: 8.382

4. miR-328 functions as an RNA decoy to modulate hnRNP E2 regulation of mRNA translation in leukemic blasts.

Authors: Anna M Eiring; Jason G Harb; Paolo Neviani; Christopher Garton; Joshua J Oaks; Riccardo Spizzo; Shujun Liu; Sebastian Schwind; Ramasamy Santhanam; Christopher J Hickey; Heiko Becker; Jason C Chandler; Raul Andino; Jorge Cortes; Peter Hokland; Claudia S Huettner; Ravi Bhatia; Denis C Roy; Stephen A Liebhaber; Michael A Caligiuri; Guido Marcucci; Ramiro Garzon; Carlo M Croce; George A Calin; Danilo Perrotti
Journal: Cell Date: 2010-03-05 Impact factor: 41.582

5. Human cellular protein VRK2 interacts specifically with Epstein-Barr virus BHRF1, a homologue of Bcl-2, and enhances cell survival.

Authors: Long-Yuan Li; Mei-Ying Liu; Hsiu-Ming Shih; Ching-Hwa Tsai; Jen-Yang Chen
Journal: J Gen Virol Date: 2006-10 Impact factor: 3.891

6. A viral microRNA cluster strongly potentiates the transforming properties of a human herpesvirus.

Authors: Regina Feederle; Sarah D Linnstaedt; Helmut Bannert; Helge Lips; Maja Bencun; Bryan R Cullen; Henri-Jacques Delecluse
Journal: PLoS Pathog Date: 2011-02-17 Impact factor: 6.823

7. A novel role for minimal introns: routing mRNAs to the cytosol.

Authors: Jiang Zhu; Fuhong He; Dapeng Wang; Kan Liu; Dawei Huang; Jingfa Xiao; Jiayan Wu; Songnian Hu; Jun Yu
Journal: PLoS One Date: 2010-04-12 Impact factor: 3.240

8. Micro RNAs of Epstein-Barr virus promote cell cycle progression and prevent apoptosis of primary human B cells.

Authors: Eri Seto; Andreas Moosmann; Sebastian Grömminger; Nicole Walz; Adam Grundhoff; Wolfgang Hammerschmidt
Journal: PLoS Pathog Date: 2010-08-19 Impact factor: 6.823

Review 9. "Cotranscriptionality": the transcription elongation complex as a nexus for nuclear transactions.

Authors: Roberto Perales; David Bentley
Journal: Mol Cell Date: 2009-10-23 Impact factor: 17.970

10. Epstein-Barr virus-encoded Bcl-2 homologue functions as a survival factor in Wp-restricted Burkitt lymphoma cell line P3HR-1.

Authors: Ami Watanabe; Seiji Maruo; Taku Ito; Miho Ito; Koichi Ricardo Katsumura; Kenzo Takada
Journal: J Virol Date: 2009-12-30 Impact factor: 5.103

12 in total

Review 1. EBV Noncoding RNAs.

Authors: Rebecca L Skalsky; Bryan R Cullen
Journal: Curr Top Microbiol Immunol Date: 2015 Impact factor: 4.291

cis-Acting effects on RNA processing and Drosha cleavage prevent Epstein-Barr virus latency III BHRF1 expression.

1. The Epstein-Barr virus Bcl-2 homolog, BHRF1, blocks apoptosis by binding to a limited amount of Bim.

2. Coupled RNA processing and transcription of intergenic primary microRNAs.

Review 3. Decoding the function of nuclear long non-coding RNAs.

4. miR-328 functions as an RNA decoy to modulate hnRNP E2 regulation of mRNA translation in leukemic blasts.

5. Human cellular protein VRK2 interacts specifically with Epstein-Barr virus BHRF1, a homologue of Bcl-2, and enhances cell survival.

6. A viral microRNA cluster strongly potentiates the transforming properties of a human herpesvirus.

7. A novel role for minimal introns: routing mRNAs to the cytosol.

8. Micro RNAs of Epstein-Barr virus promote cell cycle progression and prevent apoptosis of primary human B cells.

Review 9. "Cotranscriptionality": the transcription elongation complex as a nexus for nuclear transactions.

10. Epstein-Barr virus-encoded Bcl-2 homologue functions as a survival factor in Wp-restricted Burkitt lymphoma cell line P3HR-1.

Review 1. EBV Noncoding RNAs.

2. Evolutionary conservation of primate lymphocryptovirus microRNA targets.

Review 3. The role of miRNAs and EBV BARTs in NPC.

4. Biogenesis of Epstein-Barr virus microRNAs.

Review 5. Roles of Non-coding RNAs During Herpesvirus Infection.

Review 6. Virus-encoded microRNAs: an overview and a look to the future.

7. Roles of the linker region of RNA helicase A in HIV-1 RNA metabolism.

8. The role of A-kinase anchoring protein 95-like protein in annealing of tRNALys3 to HIV-1 RNA.

9. A Viral microRNA Cluster Regulates the Expression of PTEN, p27 and of a bcl-2 Homolog.

Review 10. Herpesviral microRNAs in Cellular Metabolism and Immune Responses.