Literature DB >> 21691623

Promoting peptide α-helix formation with dynamic covalent oxime side-chain cross-links.

Conor M Haney1, Matthew T Loch, W Seth Horne.   

Abstract

Covalent side-chain cross-linking has been shown to be a viable strategy to control peptide folding. We report here that an oxime side-chain linkage can elicit α-helical folds from peptides in aqueous solution. The bio-orthogonal bridge is formed rapidly under neutral buffered conditions, and the resulting cyclic oximes are capable of dynamic covalent exchange.

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Year:  2011        PMID： 21691623     DOI： 10.1039/c1cc12010g

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  24 in total

1.  Parallel β-sheet secondary structure is stabilized and terminated by interstrand disulfide cross-linking.

Authors:  Aaron M Almeida; Rebecca Li; Samuel H Gellman
Journal:  J Am Chem Soc       Date:  2011-12-13       Impact factor: 15.419

2.  Design of Potent and Proteolytically Stable Oxyntomodulin Analogs.

Authors:  Avinash Muppidi; Huafei Zou; Peng Yu Yang; Elizabeth Chao; Lance Sherwood; Vanessa Nunez; Ashley K Woods; Peter G Schultz; Qing Lin; Weijun Shen
Journal:  ACS Chem Biol       Date:  2016-01-04       Impact factor: 5.100

3.  Tightening up the structure, lighting up the pathway: Application of molecular constraints and light to manipulate protein folding, self-assembly and function.

Authors:  Beatrice N Markiewicz; Robert M Culik; Feng Gai
Journal:  Sci China Chem       Date:  2014-12       Impact factor: 9.445

4.  Targeting Protein-Protein Interactions of Tyrosine Phosphatases with Microarrayed Fragment Libraries Displayed on Phosphopeptide Substrate Scaffolds.

Authors:  Megan Hogan; Medhanit Bahta; Kohei Tsuji; Trung X Nguyen; Scott Cherry; George T Lountos; Joseph E Tropea; Bryan M Zhao; Xue Zhi Zhao; David S Waugh; Terrence R Burke; Robert G Ulrich
Journal:  ACS Comb Sci       Date:  2019-01-31       Impact factor: 3.784

Review 5.  An enhanced functional interrogation/manipulation of intracellular signaling pathways with the peptide 'stapling' technology.

Authors:  Y He; D Chen; W Zheng
Journal:  Oncogene       Date:  2015-03-23       Impact factor: 9.867

Review 6.  Oximes and Hydrazones in Bioconjugation: Mechanism and Catalysis.

Authors:  Dominik K Kölmel; Eric T Kool
Journal:  Chem Rev       Date:  2017-06-22       Impact factor: 60.622

7.  Development of α-helical calpain probes by mimicking a natural protein-protein interaction.

Authors:  Hyunil Jo; Nataline Meinhardt; Yibing Wu; Swapnil Kulkarni; Xiaozhen Hu; Kristin E Low; Peter L Davies; William F DeGrado; Doron C Greenbaum
Journal:  J Am Chem Soc       Date:  2012-10-11       Impact factor: 15.419

8.  Effects of side chains in helix nucleation differ from helix propagation.

Authors:  Stephen E Miller; Andrew M Watkins; Neville R Kallenbach; Paramjit S Arora
Journal:  Proc Natl Acad Sci U S A       Date:  2014-04-21       Impact factor: 11.205

9.  Bridged Analogues for p53-Dependent Cancer Therapy Obtained by S-Alkylation.

Authors:  Ewa D Micewicz; Shantanu Sharma; Alan J Waring; Hai T Luong; William H McBride; Piotr Ruchala
Journal:  Int J Pept Res Ther       Date:  2015-08-19       Impact factor: 1.931

10.  A two-component 'double-click' approach to peptide stapling.

Authors:  Yu Heng Lau; Yuteng Wu; Peterson de Andrade; Warren R J D Galloway; David R Spring
Journal:  Nat Protoc       Date:  2015-03-12       Impact factor: 13.491
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