Literature DB >> 21688199

Biological reactivity of TiO2 nanoparticles assessed by ex vivo testing.

Janez Valant1, Damjana Drobne.   

Abstract

Isolated digestive gland epithelium from a model invertebrate organism was used in an ex vivo system to assess the potential of nanoparticulate TiO(2) to disrupt cell membranes. Primary particle size, surface area, concentration of particles in a suspension, and duration of exposure to TiO(2) particles were all found to have effects, which are observed at concentrations of nano-TiO(2) as low as 1 μg mL(-1). The test system employed here can be used as a fast screening tool to assess biological potential of nanoparticles with similar chemical composition but different size, concentration, or duration of exposure. We discuss the potential of ex vivo tests to avoid some of the limitations of conventional in vitro tests.

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Year:  2011        PMID： 21688199     DOI： 10.1007/s00709-011-0298-x

Source DB:  PubMed          Journal:  Protoplasma        ISSN： 0033-183X            Impact factor:   3.356


  23 in total

1.  The effect of particle design on cellular internalization pathways.

Authors:  Stephanie E A Gratton; Patricia A Ropp; Patrick D Pohlhaus; J Christopher Luft; Victoria J Madden; Mary E Napier; Joseph M DeSimone
Journal:  Proc Natl Acad Sci U S A       Date:  2008-08-12       Impact factor: 11.205

2.  Cytotoxic effects of aggregated nanomaterials.

Authors:  Karla Soto; K M Garza; L E Murr
Journal:  Acta Biomater       Date:  2007-02-01       Impact factor: 8.947

3.  Are in vitro tests suitable for regulatory use?

Authors:  Thomas Hartung; George Daston
Journal:  Toxicol Sci       Date:  2009-07-17       Impact factor: 4.849

4.  Differential gene expression in Daphnia magna suggests distinct modes of action and bioavailability for ZnO nanoparticles and Zn ions.

Authors:  Helen C Poynton; James M Lazorchak; Christopher A Impellitteri; Mark E Smith; Kim Rogers; Manomita Patra; Katherine A Hammer; H Joel Allen; Chris D Vulpe
Journal:  Environ Sci Technol       Date:  2010-12-13       Impact factor: 9.028

5.  Size-dependent toxicity of metal oxide particles--a comparison between nano- and micrometer size.

Authors:  Hanna L Karlsson; Johanna Gustafsson; Pontus Cronholm; Lennart Möller
Journal:  Toxicol Lett       Date:  2009-03-26       Impact factor: 4.372

6.  Effects of ultrafine TiO2 particles on gene expression profile in human keratinocytes without illumination: involvement of extracellular matrix and cell adhesion.

Authors:  Katsuhide Fujita; Masanori Horie; Haruhisa Kato; Shigehisa Endoh; Mie Suzuki; Ayako Nakamura; Arisa Miyauchi; Kazuhiro Yamamoto; Shinichi Kinugasa; Keiko Nishio; Yasukazu Yoshida; Hitoshi Iwahashi; Junko Nakanishi
Journal:  Toxicol Lett       Date:  2009-08-18       Impact factor: 4.372

7.  TEM evidence of ultrastructural alteration on Pseudomonas aeruginosa by photocatalytic TiO2 thin films.

Authors:  P Amézaga-Madrid; R Silveyra-Morales; L Córdoba-Fierro; G V Nevárez-Moorillón; M Miki-Yoshida; E Orrantia-Borunda; F J Solís
Journal:  J Photochem Photobiol B       Date:  2003-04       Impact factor: 6.252

8.  Surface chemistry influences cancer killing effect of TiO2 nanoparticles.

Authors:  Paul Thevenot; Jai Cho; Dattatray Wavhal; Richard B Timmons; Liping Tang
Journal:  Nanomedicine       Date:  2008-05-23       Impact factor: 5.307

9.  Inhibitor of differentiation 1 (Id1) expression attenuates the degree of TiO2-induced cytotoxicity in H1299 non-small cell lung cancer cells.

Authors:  Young Sook Lee; Seokjoo Yoon; Hea Jin Yoon; Kyuhong Lee; Hyoun Kyoung Yoon; Jeung-Hoon Lee; Chang Woo Song
Journal:  Toxicol Lett       Date:  2009-05-30       Impact factor: 4.372

10.  Toxicity of nanosized and bulk ZnO, CuO and TiO2 to bacteria Vibrio fischeri and crustaceans Daphnia magna and Thamnocephalus platyurus.

Authors:  Margit Heinlaan; Angela Ivask; Irina Blinova; Henri-Charles Dubourguier; Anne Kahru
Journal:  Chemosphere       Date:  2008-01-14       Impact factor: 7.086
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  4 in total

1.  Impact of TiO₂ nanoparticles on Vicia narbonensis L.: potential toxicity effects.

Authors:  M Ruffini Castiglione; L Giorgetti; R Cremonini; S Bottega; C Spanò
Journal:  Protoplasma       Date:  2014-05-03       Impact factor: 3.356

2.  Comparison of cellular uptake and inflammatory response via toll-like receptor 4 to lipopolysaccharide and titanium dioxide nanoparticles.

Authors:  Sharmy Saimon Mano; Koki Kanehira; Akiyoshi Taniguchi
Journal:  Int J Mol Sci       Date:  2013-06-26       Impact factor: 5.923

Review 3.  Engineered nanomaterials in food: implications for food safety and consumer health.

Authors:  Alina Martirosyan; Yves-Jacques Schneider
Journal:  Int J Environ Res Public Health       Date:  2014-05-28       Impact factor: 3.390

4.  Multilaboratory evaluation of 15 bioassays for (eco)toxicity screening and hazard ranking of engineered nanomaterials: FP7 project NANOVALID.

Authors:  Olesja M Bondarenko; Margit Heinlaan; Mariliis Sihtmäe; Angela Ivask; Imbi Kurvet; Elise Joonas; Anita Jemec; Marika Mannerström; Tuula Heinonen; Rohit Rekulapelly; Shashi Singh; Jing Zou; Ilmari Pyykkö; Damjana Drobne; Anne Kahru
Journal:  Nanotoxicology       Date:  2016-06-28       Impact factor: 5.913
  4 in total

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