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Literature DB >> 21681307

In vivo cell death mediated by synthetic ion channels.

Bryan A Smith¹, Megan M Daschbach, Seth T Gammon, Shuzhang Xiao, Sarah E Chapman, Caroline Hudson, Mark Suckow, David Piwnica-Worms, George W Gokel, W Matthew Leevy.

Abstract

Synthetic ion channel hydraphiles, which are known to infiltrate membranes and disrupt ion homeostasis, were tested as direct injection toxins in live mice as potential schlerotic agents. The study uses a near-IR dye to image and evaluate the success of the approach.

Entities: CellLine Chemical Disease Species

Mesh：

Substances：
Ion Channels

Year: 2011 PMID： 21681307 PMCID： PMC3608405 DOI： 10.1039/c1cc12933c

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

23 in total

1. Synthetic ion channel activity documented by electrophysiological methods in living cells.

Authors: W Matthew Leevy; James E Huettner; Robert Pajewski; Paul H Schlesinger; George W Gokel
Journal: J Am Chem Soc Date: 2004-12-08 Impact factor: 15.419

2. Structure-activity relationships, kinetics, selectivity, and mechanistic studies of synthetic hydraphile channels in bacterial and mammalian cells.

Authors: W Matthew Leevy; Seth T Gammon; Tatiana Levchenko; David D Daranciang; Oscar Murillo; Vladimir Torchilin; David Piwnica-Worms; James E Huettner; George W Gokel
Journal: Org Biomol Chem Date: 2005-08-26 Impact factor: 3.876

3. A synthetic, chloride-selective channel that alters chloride transport in epithelial cells.

Authors: Robert Pajewski; Raquel Garcia-Medina; Steven L Brody; W Matthew Leevy; Paul H Schlesinger; George W Gokel
Journal: Chem Commun (Camb) Date: 2005-11-22 Impact factor: 6.222

4. Selective recognition of bacterial membranes by zinc(II)-coordination complexes.

Authors: W Matthew Leevy; James R Johnson; C Lakshmi; Joshua Morris; Manuel Marquez; Bradley D Smith
Journal: Chem Commun (Camb) Date: 2006-02-16 Impact factor: 6.222

5. Optical imaging of bacterial infection in living mice using a fluorescent near-infrared molecular probe.

Authors: W Matthew Leevy; Seth T Gammon; Hua Jiang; James R Johnson; Dustin J Maxwell; Erin N Jackson; Manuel Marquez; David Piwnica-Worms; Bradley D Smith
Journal: J Am Chem Soc Date: 2006-12-27 Impact factor: 15.419

6. In vivo detection of apoptotic cells in the testis using fluorescence labeled annexin V in a mouse model of testicular torsion.

Authors: Sang-Kuk Yang; Sharon Attipoe; Adam P Klausner; Rong Tian; Dongfeng Pan; Tyvin A Rich; Terry T Turner; William D Steers; Jeffrey J Lysiak
Journal: J Urol Date: 2006-08 Impact factor: 7.450

Review 7. Image guided tumour ablation.

Authors: A R Gillams
Journal: Cancer Imaging Date: 2005-09-21 Impact factor: 3.909

8. Fluorescent detection of apoptotic cells by using zinc coordination complexes with a selective affinity for membrane surfaces enriched with phosphatidylserine.

Authors: Roger G Hanshaw; C Lakshmi; Timothy N Lambert; James R Johnson; Bradley D Smith
Journal: Chembiochem Date: 2005-12 Impact factor: 3.164

In vivo cell death mediated by synthetic ion channels.

1. Synthetic ion channel activity documented by electrophysiological methods in living cells.

2. Structure-activity relationships, kinetics, selectivity, and mechanistic studies of synthetic hydraphile channels in bacterial and mammalian cells.

3. A synthetic, chloride-selective channel that alters chloride transport in epithelial cells.

4. Selective recognition of bacterial membranes by zinc(II)-coordination complexes.

5. Optical imaging of bacterial infection in living mice using a fluorescent near-infrared molecular probe.

6. In vivo detection of apoptotic cells in the testis using fluorescence labeled annexin V in a mouse model of testicular torsion.

Review 7. Image guided tumour ablation.

8. Fluorescent detection of apoptotic cells by using zinc coordination complexes with a selective affinity for membrane surfaces enriched with phosphatidylserine.

9. Correlation of bilayer membrane cation transport and biological activity in alkyl-substituted lariat ethers.

Review 10. Injection sclerotherapy for varicose veins.

Review 1. Biomarkers and molecular probes for cell death imaging and targeted therapeutics.

2. Polyhydrazide-Based Organic Nanotubes as Efficient and Selective Artificial Iodide Channels.

3. A halogen bond-mediated highly active artificial chloride channel with high anticancer activity.

4. Hydraphiles: a rigorously studied class of synthetic channel compounds with in vivo activity.

Review 5. Recent Advances in Bioactive Artificial Ionophores.