Arundhati Roy1, Himanshu Joshi2, Ruijuan Ye3, Jie Shen1, Feng Chen1, Aleksei Aksimentiev2, Huaqiang Zeng1. 1. NanoBio Lab, 31 Biopolis Way, The Nanos, Singapore, 138669, Singapore. 2. Department of Physics and Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA. 3. Department of Chemical and Biomolecular Engineering, National University of Singapore, Singapore, 117585, Singapore.
Abstract
Reported herein is a series of pore-containing polymeric nanotubes based on a hydrogen-bonded hydrazide backbone. Nanotubes of suitable lengths, possessing a hollow cavity of about a 6.5 Å diameter, mediate highly efficient transport of diverse types of anions, rather than cations, across lipid membranes. The reported polymer channel, having an average molecular weight of 18.2 kDa and 3.6 nm in helical height, exhibits the highest anion-transport activities for iodide (EC50 =0.042 μm or 0.028 mol % relative to lipid), whcih is transported 10 times more efficiently than chlorides (EC50 =0.47 μm). Notably, even in cholesterol-rich environment, iodide transport activity remains high with an EC50 of 0.37 μm. Molecular dynamics simulation studies confirm that the channel is highly selective for anions and that such anion selectivity arises from a positive electrostatic potential of the central lumen rendered by the interior-pointing methyl groups.
Reported herein is a series of pore-containing polymeric nanotubes based oical">n a n class="Chemical">hydrogen-bonded hydrazide backbone. Nanotubes of suitable lengths, possessing a hollow cavity of about a 6.5 Å diameter, mediate highly efficient transport of diverse types of anions, rather than cations, across lipid membranes. The reported polymer channel, having an average molecular weight of 18.2 kDa and 3.6 nm in helical height, exhibits the highest anion-transport activities for iodide (EC50 =0.042 μm or 0.028 mol % relative to lipid), whcih is transported 10 times more efficiently than chlorides (EC50 =0.47 μm). Notably, even in cholesterol-rich environment, iodide transport activity remains high with an EC50 of 0.37 μm. Molecular dynamics simulation studies confirm that the channel is highly selective for anions and that such anion selectivity arises from a positive electrostatic potential of the central lumen rendered by the interior-pointing methyl groups.
Authors: Sung-Kyun Ko; Sung Kuk Kim; Andrew Share; Vincent M Lynch; Jinhong Park; Wan Namkung; Wim Van Rossom; Nathalie Busschaert; Philip A Gale; Jonathan L Sessler; Injae Shin Journal: Nat Chem Date: 2014-08-11 Impact factor: 24.427
Authors: Kerstin Göpfrich; Chen-Yu Li; Iwona Mames; Satya Prathyusha Bhamidimarri; Maria Ricci; Jejoong Yoo; Adam Mames; Alexander Ohmann; Mathias Winterhalter; Eugen Stulz; Aleksei Aksimentiev; Ulrich F Keyser Journal: Nano Lett Date: 2016-06-29 Impact factor: 11.189