Literature DB >> 21669527

Targeted and armed oncolytic adenovirus via chemoselective modification.

Partha S Banerjee1, Edison S Zuniga, Iwao Ojima, Isaac S Carrico.   

Abstract

Oncolytic adenoviruses (Ads) are an emerging alternative therapy for cancer; however, clinical trial have not yet demonstrated sufficient efficacy. When oncolytic Ads are used in combination with taxoids a synergistic increase in both cytotoxicity and viral replication is observed. In order to generate a next generation oncolytic adenovirus, virion were physically conjugated to a highly potent taxoid, SB-T-1214, and a folate targeting motif. Conjugation was enabled via the metabolic incorporation of non-canonical monosaccharides (O-GlcNAz) and amino acids (homopropargylglycine), which served as sites for chemoselective modification.
Copyright © 2011 Elsevier Ltd. All rights reserved.

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Year:  2011        PMID： 21669527      PMCID： PMC3413283          DOI： 10.1016/j.bmcl.2011.05.039

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  24 in total

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Authors:  Wei Xia; Philip S Low
Journal:  J Med Chem       Date:  2010-10-14       Impact factor: 7.446

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Authors:  Jeremiah A Johnson; Ying Y Lu; James A Van Deventer; David A Tirrell
Journal:  Curr Opin Chem Biol       Date:  2010-11-09       Impact factor: 8.822

3.  Syntheses and evaluation of novel fatty acid-second-generation taxoid conjugates as promising anticancer agents.

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Journal:  Bioorg Med Chem Lett       Date:  2005-11-18       Impact factor: 2.823

Review 4.  Oncolytic adenoviruses for the treatment of human cancer: focus on translational and clinical data.

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Journal:  Mol Pharm       Date:  2010-12-22       Impact factor: 4.939

5.  Synergistic anti-tumor effects between oncolytic vaccinia virus and paclitaxel are mediated by the IFN response and HMGB1.

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6.  Accelerated bioorthogonal conjugation: a practical method for the ligation of diverse functional molecules to a polyvalent virus scaffold.

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7.  Chemoselective attachment of small molecule effector functionality to human adenoviruses facilitates gene delivery to cancer cells.

Authors:  Partha Sarathi Banerjee; Philomena Ostapchuk; Patrick Hearing; Isaac Carrico
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8.  Antitumor synergy of CV787, a prostate cancer-specific adenovirus, and paclitaxel and docetaxel.

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9.  Metabolic cross-talk allows labeling of O-linked beta-N-acetylglucosamine-modified proteins via the N-acetylgalactosamine salvage pathway.

Authors:  Michael Boyce; Isaac S Carrico; Anjali S Ganguli; Seok-Ho Yu; Matthew J Hangauer; Sarah C Hubbard; Jennifer J Kohler; Carolyn R Bertozzi
Journal:  Proc Natl Acad Sci U S A       Date:  2011-02-07       Impact factor: 11.205

10.  Identification of human uroplakin II promoter and its use in the construction of CG8840, a urothelium-specific adenovirus variant that eliminates established bladder tumors in combination with docetaxel.

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  9 in total

1.  Design, Synthesis and Application of Fluorine-Labeled Taxoids as 19F NMR Probes for the Metabolic Stability Assessment of Tumor-Targeted Drug Delivery Systems.

Authors:  Joshua D Seitz; Jacob G Vineberg; Longfei Wei; Jonathan F Khan; Brendan Lichtenthal; Chi-Feng Lin; Iwao Ojima
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Review 2.  Physical, chemical, and synthetic virology: Reprogramming viruses as controllable nanodevices.

Authors:  Maria Yanqing Chen; Susan S Butler; Weitong Chen; Junghae Suh
Journal:  Wiley Interdiscip Rev Nanomed Nanobiotechnol       Date:  2018-11-08

3.  Amino Acid Thioester Derivatives: A Highly Promising Scaffold for the Development of Metallo-β-lactamase L1 Inhibitors.

Authors:  Xiao-Long Liu; Ying Shi; Joon S Kang; Peter Oelschlaeger; Ke-Wu Yang
Journal:  ACS Med Chem Lett       Date:  2015-04-23       Impact factor: 4.345

4.  Design, synthesis and biological evaluation of a highly-potent and cancer cell selective folate-taxoid conjugate.

Authors:  Joshua D Seitz; Jacob G Vineberg; Evan Herlihy; Bora Park; Eduard Melief; Iwao Ojima
Journal:  Bioorg Med Chem       Date:  2015-03-06       Impact factor: 3.641

5.  Design, synthesis, and biological evaluation of theranostic vitamin-linker-taxoid conjugates.

Authors:  Jacob G Vineberg; Tao Wang; Edison S Zuniga; Iwao Ojima
Journal:  J Med Chem       Date:  2015-02-18       Impact factor: 7.446

6.  Click labeling of unnatural sugars metabolically incorporated into viral envelope glycoproteins enables visualization of single particle fusion.

Authors:  Yoon Hyeun Oum; Tanay M Desai; Mariana Marin; Gregory B Melikyan
Journal:  J Virol Methods       Date:  2016-03-29       Impact factor: 2.014

7.  Retargeting of viruses to generate oncolytic agents.

Authors:  M H Verheije; P J M Rottier
Journal:  Adv Virol       Date:  2011-11-14

8.  Design, synthesis, and biological evaluations of tumor-targeting dual-warhead conjugates for a taxoid-camptothecin combination chemotherapy.

Authors:  Jacob G Vineberg; Edison S Zuniga; Anushree Kamath; Ying-Jen Chen; Joshua D Seitz; Iwao Ojima
Journal:  J Med Chem       Date:  2014-06-19       Impact factor: 7.446

9.  Design, Synthesis, and Biological Evaluations of Asymmetric Bow-Tie PAMAM Dendrimer-Based Conjugates for Tumor-Targeted Drug Delivery.

Authors:  Tao Wang; Yaozhong Zhang; Longfei Wei; Yuhan G Teng; Tadashi Honda; Iwao Ojima
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  9 in total

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