Literature DB >> 21668393

The bone marrow microenvironment and leukemia: biology and therapeutic targeting.

Edward Allan R Sison1, Patrick Brown.   

Abstract

Multiple studies have demonstrated that interaction with the bone marrow stromal microenvironment contributes to the survival of leukemia cells. One explanation for this phenomenon is the interaction between the cell surface receptors CXCR4 and CXCL12. Through CXCL12/CXCR4-mediated chemotaxis, leukemia cells migrate to microscopic niches within the bone marrow, which leads to increased proliferation and survival. Several studies have suggested that increased CXCR4 expression may portend a poor prognosis in various types of leukemia, possibly due to increased protection of leukemia cells by bone marrow stroma. A potential therapeutic strategy to overcome this stromal-mediated survival advantage is to target CXCR4. Inhibition of CXCR4 may allow leukemia cells to be released from bone marrow niches that confer resistance to chemotherapy and negate the survival benefit imparted by bone marrow stroma.

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Year:  2011        PMID： 21668393      PMCID： PMC3131221          DOI： 10.1586/ehm.11.30

Source DB:  PubMed          Journal:  Expert Rev Hematol        ISSN： 1747-4094            Impact factor:   2.929


  129 in total

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Journal:  J Immunol       Date:  1998-01-15       Impact factor: 5.422

2.  Genomic organization and functional characterization of the chemokine receptor CXCR4, a major entry co-receptor for human immunodeficiency virus type 1.

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Journal:  J Biol Chem       Date:  1998-02-20       Impact factor: 5.157

3.  Vascular endothelial growth factor, a possible paracrine growth factor in human acute myeloid leukemia.

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Journal:  Blood       Date:  1997-03-15       Impact factor: 22.113

4.  Spectrum of tumor angiogenesis in the bone marrow of children with acute lymphoblastic leukemia.

Authors:  A R Perez-Atayde; S E Sallan; U Tedrow; S Connors; E Allred; J Folkman
Journal:  Am J Pathol       Date:  1997-03       Impact factor: 4.307

5.  The chemokine SDF-1, stromal cell-derived factor 1, attracts early stage B cell precursors via the chemokine receptor CXCR4.

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Journal:  Eur J Immunol       Date:  1997-07       Impact factor: 5.532

6.  CXCR4 expression during lymphopoiesis: implications for human immunodeficiency virus type 1 infection of the thymus.

Authors:  S G Kitchen; J A Zack
Journal:  J Virol       Date:  1997-09       Impact factor: 5.103

7.  Inhibition of T-tropic HIV strains by selective antagonization of the chemokine receptor CXCR4.

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Journal:  J Exp Med       Date:  1997-10-20       Impact factor: 14.307

8.  B lymphocyte chemotaxis regulated in association with microanatomic localization, differentiation state, and B cell receptor engagement.

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Journal:  J Exp Med       Date:  1998-03-02       Impact factor: 14.307

9.  Phorbol esters and SDF-1 induce rapid endocytosis and down modulation of the chemokine receptor CXCR4.

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Journal:  J Cell Biol       Date:  1997-11-03       Impact factor: 10.539

10.  A small molecule CXCR4 inhibitor that blocks T cell line-tropic HIV-1 infection.

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  47 in total

1.  In vivo RNAi screening identifies Pafah1b3 as a target for combination therapy with TKIs in BCR-ABL1+ BCP-ALL.

Authors:  Eleanor R C Fiedler; Arjun Bhutkar; Emily Lawler; Rana Besada; Michael T Hemann
Journal:  Blood Adv       Date:  2018-06-12

Review 2.  Creating artificial lymphoid tissues to study immunity and hematological malignancies.

Authors:  Shivem B Shah; Ankur Singh
Journal:  Curr Opin Hematol       Date:  2017-07       Impact factor: 3.284

3.  Stromal CYR61 Confers Resistance to Mitoxantrone via Spleen Tyrosine Kinase Activation in Human Acute Myeloid Leukaemia.

Authors:  Xin Long; Yang Yu; Laszlo Perlaky; Tsz-Kwong Man; Michele S Redell
Journal:  Br J Haematol       Date:  2015-05-14       Impact factor: 6.998

4.  Bone marrow stroma-mediated resistance to FLT3 inhibitors in FLT3-ITD AML is mediated by persistent activation of extracellular regulated kinase.

Authors:  Xiaochuan Yang; Amy Sexauer; Mark Levis
Journal:  Br J Haematol       Date:  2013-10-10       Impact factor: 6.998

Review 5.  Targeting the molecular and cellular interactions of the bone marrow niche in immunologic disease.

Authors:  Jaime M Brozowski; Matthew J Billard; Teresa K Tarrant
Journal:  Curr Allergy Asthma Rep       Date:  2014-02       Impact factor: 4.806

6.  Biomaterial-enabled delivery of SDF-1α at the ventral side of breast cancer cells reveals a crosstalk between cell receptors to promote the invasive phenotype.

Authors:  Xi Qiu Liu; Laure Fourel; Fabien Dalonneau; Rabia Sadir; Salome Leal; Hugues Lortat-Jacob; Marianne Weidenhaupt; Corinne Albiges-Rizo; Catherine Picart
Journal:  Biomaterials       Date:  2017-02-27       Impact factor: 12.479

7.  Targeting of mTORC1/2 by the mTOR kinase inhibitor PP242 induces apoptosis in AML cells under conditions mimicking the bone marrow microenvironment.

Authors:  Zhihong Zeng; Yue Xi Shi; Twee Tsao; YiHua Qiu; Steven M Kornblau; Keith A Baggerly; Wenbin Liu; Katti Jessen; Yi Liu; Hagop Kantarjian; Christian Rommel; David A Fruman; Michael Andreeff; Marina Konopleva
Journal:  Blood       Date:  2012-07-23       Impact factor: 22.113

Review 8.  Understanding the bone marrow microenvironment in hematologic malignancies: A focus on chemokine, integrin, and extracellular vesicle signaling.

Authors:  Edward Allan Racela Sison; Peter Kurre; Yong-Mi Kim
Journal:  Pediatr Hematol Oncol       Date:  2017-12-06       Impact factor: 1.969

9.  High expression of connective tissue growth factor accelerates dissemination of leukaemia.

Authors:  J E Wells; M Howlett; H M Halse; J Heng; J Ford; L C Cheung; A L Samuels; M Crook; A K Charles; C H Cole; U R Kees
Journal:  Oncogene       Date:  2016-01-25       Impact factor: 9.867

Review 10.  Roles of Rho GTPases in leucocyte and leukaemia cell transendothelial migration.

Authors:  Elvira Infante; Anne J Ridley
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2013-09-23       Impact factor: 6.237
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