Literature DB >> 29211600

Understanding the bone marrow microenvironment in hematologic malignancies: A focus on chemokine, integrin, and extracellular vesicle signaling.

Edward Allan Racela Sison1, Peter Kurre2, Yong-Mi Kim3.   

Abstract

Signaling between leukemia cells and nonhematopoietic cells in the bone marrow microenvironment contributes to leukemia cell growth and survival. This complicated extrinsic mechanism of chemotherapy resistance relies on a number of pathways and factors, some of which have yet to be determined. Research on cell-cell crosstalk the bone marrow microenvironment in acute leukemia was presented at the 2016 annual Therapeutic Advances in Childhood Leukemia (TACL) investigator meeting. This review summarizes the mini-symposium proceedings and focuses on chemokine signaling via the cell surface receptor CXCR4, adhesion molecule signaling via integrin α4, and crosstalk between leukemia cells and the bone marrow microenvironment that is mediated through extracellular vesicles.

Entities:  

Keywords:  Bone marrow microenvironment; CXCR4; extracellular vesicles; integrin; leukemia; pediatric

Mesh：

Substances：

Year:  2017        PMID： 29211600      PMCID： PMC6516746          DOI： 10.1080/08880018.2017.1395938

Source DB:  PubMed          Journal:  Pediatr Hematol Oncol        ISSN： 0888-0018            Impact factor:   1.969


  101 in total

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Authors:  R L Juliano
Journal:  Annu Rev Pharmacol Toxicol       Date:  2002       Impact factor: 13.820

2.  Is high expression of the chemokine receptor CXCR-4 of predictive value for early relapse in childhood acute lymphoblastic leukaemia?

Authors:  Pascale Schneider; Marc Vasse; Aws Al Bayati; Bernard Lenormand; Jean-Pierre Vannier
Journal:  Br J Haematol       Date:  2002-11       Impact factor: 6.998

3.  Functional response of leukaemic blasts to stromal cell-derived factor-1 correlates with preferential expression of the chemokine receptor CXCR4 in acute myelomonocytic and lymphoblastic leukaemia.

Authors:  R Möhle; M Schittenhelm; C Failenschmid; F Bautz; K Kratz-Albers; H Serve; W Brugger; L Kanz
Journal:  Br J Haematol       Date:  2000-09       Impact factor: 6.998

Review 4.  Extracellular matrix and integrin signalling: the shape of things to come.

Authors:  N J Boudreau; P L Jones
Journal:  Biochem J       Date:  1999-05-01       Impact factor: 3.857

5.  Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis.

Authors:  Christian Thiede; Christine Steudel; Brigitte Mohr; Markus Schaich; Ulrike Schäkel; Uwe Platzbecker; Martin Wermke; Martin Bornhäuser; Markus Ritter; Andreas Neubauer; Gerhard Ehninger; Thomas Illmer
Journal:  Blood       Date:  2002-06-15       Impact factor: 22.113

6.  High expression of the chemokine receptor CXCR4 predicts extramedullary organ infiltration in childhood acute lymphoblastic leukaemia.

Authors:  R Crazzolara; A Kreczy; G Mann; A Heitger; G Eibl; F M Fink; R Möhle; B Meister
Journal:  Br J Haematol       Date:  2001-12       Impact factor: 6.998

7.  Expression of adhesion molecules in childhood B-lineage-cell neoplasms.

Authors:  J Hara; Y Matsuda; H Fujisaki; S Tokimasa; H Ohta; Y Osagi; K Takai
Journal:  Int J Hematol       Date:  2000-07       Impact factor: 2.490

8.  Stromal cells regulate survival of B-lineage leukemic cells during chemotherapy.

Authors:  R E Mudry; J E Fortney; T York; B M Hall; L F Gibson
Journal:  Blood       Date:  2000-09-01       Impact factor: 22.113

Review 9.  Alpha 4 integrin antagonists.

Authors:  David Y Jackson
Journal:  Curr Pharm Des       Date:  2002       Impact factor: 3.116

10.  Signal transduction by CXC chemokine receptor 4. Stromal cell-derived factor 1 stimulates prolonged protein kinase B and extracellular signal-regulated kinase 2 activation in T lymphocytes.

Authors:  B Tilton; L Ho; E Oberlin; P Loetscher; F Baleux; I Clark-Lewis; M Thelen
Journal:  J Exp Med       Date:  2000-08-07       Impact factor: 14.307
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  5 in total

Review 1.  Integrin-Mediated Adhesion and Chemoresistance of Acute Lymphoblastic Leukemia Cells Residing in the Bone Marrow or the Central Nervous System.

Authors:  Bibi Fatima Syed Shah Scharff; Signe Modvig; Hanne Vibeke Marquart; Claus Christensen
Journal:  Front Oncol       Date:  2020-05-22       Impact factor: 6.244

Review 2.  Cadherins, Selectins, and Integrins in CAM-DR in Leukemia.

Authors:  Hye Na Kim; Yongsheng Ruan; Heather Ogana; Yong-Mi Kim
Journal:  Front Oncol       Date:  2020-12-10       Impact factor: 6.244

3.  Preclinical Evaluation of a Novel Dual Targeting PI3Kδ/BRD4 Inhibitor, SF2535, in B-Cell Acute Lymphoblastic Leukemia.

Authors:  Yongsheng Ruan; Hye Na Kim; Heather A Ogana; Zesheng Wan; Samantha Hurwitz; Cydney Nichols; Nour Abdel-Azim; Ariana Coba; Seyoung Seo; Yong-Hwee Eddie Loh; Eun Ji Gang; Hisham Abdel-Azim; Chih-Lin Hsieh; Michael R Lieber; Chintan Parekh; Dhananjaya Pal; Deepa Bhojwani; Donald L Durden; Yong-Mi Kim
Journal:  Front Oncol       Date:  2021-12-01       Impact factor: 6.244

4.  In vitro and in vivo effects of AVA4746, a novel competitive antagonist of the ligand binding of VLA-4, in B-cell acute lymphoblastic leukemia.

Authors:  Yongsheng Ruan; Hye Na Kim; Heather A Ogana; Eun Ji Gang; Shuangyue Li; Hsiao-Chuan Liu; Deepa Bhojwani; Alan S Wayne; Mo Yang; Yong-Mi Kim
Journal:  Exp Ther Med       Date:  2021-11-15       Impact factor: 2.447

Review 5.  Wnt Signaling in Leukemia and Its Bone Marrow Microenvironment.

Authors:  Yongsheng Ruan; Hye Na Kim; Heather Ogana; Yong-Mi Kim
Journal:  Int J Mol Sci       Date:  2020-08-28       Impact factor: 5.923
  5 in total

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