Literature DB >> 2165605

Oxidation-reduction sensitive interaction of a cellular 50-kDa protein with an RNA hairpin in the 5' noncoding region of the poliovirus genome.

L Najita1, P Sarnow.   

Abstract

Genetic and biochemical analyses of the 5' noncoding region of poliovirus have indicated the importance of this region in both translation and amplification of the viral RNA. The role of the cellular machinery required for these events is just beginning to be revealed. Using an RNA gel retention assay, we have identified a cellular 50-kDa protein that forms a specific complex with a stable stem-loop structure present in the viral 5' noncoding region. The formation of the RNA-protein complex is dependent on the availability of free sulfhydryl groups in the protein. The possible involvement of this RNA-protein complex in the regulation of viral gene expression is discussed.

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Year:  1990        PMID： 2165605      PMCID： PMC54425          DOI： 10.1073/pnas.87.15.5846

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  22 in total

1.  New model for the secondary structure of the 5' non-coding RNA of poliovirus is supported by biochemical and genetic data that also show that RNA secondary structure is important in neurovirulence.

Authors:  M A Skinner; V R Racaniello; G Dunn; J Cooper; P D Minor; J W Almond
Journal:  J Mol Biol       Date:  1989-05-20       Impact factor: 5.469

2.  The deletion of 41 proximal nucleotides reverts a poliovirus mutant containing a temperature-sensitive lesion in the 5' noncoding region of genomic RNA.

Authors:  S L Dildine; B L Semler
Journal:  J Virol       Date:  1989-02       Impact factor: 5.103

3.  Role of 3'-end sequences in infectivity of poliovirus transcripts made in vitro.

Authors:  P Sarnow
Journal:  J Virol       Date:  1989-01       Impact factor: 5.103

4.  A poliovirus temperature-sensitive RNA synthesis mutant located in a noncoding region of the genome.

Authors:  P Sarnow; H D Bernstein; D Baltimore
Journal:  Proc Natl Acad Sci U S A       Date:  1986-02       Impact factor: 11.205

5.  Oxidation-reduction and the molecular mechanism of a regulatory RNA-protein interaction.

Authors:  M W Hentze; T A Rouault; J B Harford; R D Klausner
Journal:  Science       Date:  1989-04-21       Impact factor: 47.728

6.  Electrophoretic separation of complexes involved in the splicing of precursors to mRNAs.

Authors:  M M Konarska; P A Sharp
Journal:  Cell       Date:  1986-09-12       Impact factor: 41.582

7.  Comparative sequence analysis of the 5' noncoding region of the enteroviruses and rhinoviruses.

Authors:  V M Rivera; J D Welsh; J V Maizel
Journal:  Virology       Date:  1988-07       Impact factor: 3.616

8.  Catalytic mechanism and inhibition of tRNA (uracil-5-)methyltransferase: evidence for covalent catalysis.

Authors:  D V Santi; L W Hardy
Journal:  Biochemistry       Date:  1987-12-29       Impact factor: 3.162

9.  Translation of glucose-regulated protein 78/immunoglobulin heavy-chain binding protein mRNA is increased in poliovirus-infected cells at a time when cap-dependent translation of cellular mRNAs is inhibited.

Authors:  P Sarnow
Journal:  Proc Natl Acad Sci U S A       Date:  1989-08       Impact factor: 11.205

10.  Internal initiation of translation of eukaryotic mRNA directed by a sequence derived from poliovirus RNA.

Authors:  J Pelletier; N Sonenberg
Journal:  Nature       Date:  1988-07-28       Impact factor: 49.962
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  34 in total

1.  Linker scanning mutagenesis of the internal ribosome entry site of poliovirus RNA.

Authors:  A A Haller; B L Semler
Journal:  J Virol       Date:  1992-08       Impact factor: 5.103

2.  Cap-independent translation by the 5' untranslated region of Theiler's murine encephalomyelitis virus.

Authors:  P K Bandyopadhyay; C Wang; H L Lipton
Journal:  J Virol       Date:  1992-11       Impact factor: 5.103

3.  Specific interactions of HeLa cell proteins with proposed translation domains of the poliovirus 5' noncoding region.

Authors:  J R Gebhard; E Ehrenfeld
Journal:  J Virol       Date:  1992-05       Impact factor: 5.103

4.  Intracellular modifications induced by poliovirus reduce the requirement for structural motifs in the 5' noncoding region of the genome involved in internal initiation of protein synthesis.

Authors:  N Percy; G J Belsham; J K Brangwyn; M Sullivan; D M Stone; J W Almond
Journal:  J Virol       Date:  1992-03       Impact factor: 5.103

5.  Conservation of RNA-protein interactions among picornaviruses.

Authors:  S L Dildine; B L Semler
Journal:  J Virol       Date:  1992-07       Impact factor: 5.103

6.  Evolution of the Sabin type 1 poliovirus in humans: characterization of strains isolated from patients with vaccine-associated paralytic poliomyelitis.

Authors:  M M Georgescu; J Balanant; A Macadam; D Otelea; M Combiescu; A A Combiescu; R Crainic; F Delpeyroux
Journal:  J Virol       Date:  1997-10       Impact factor: 5.103

7.  Translation of poliovirus RNA: role of an essential cis-acting oligopyrimidine element within the 5' nontranslated region and involvement of a cellular 57-kilodalton protein.

Authors:  T V Pestova; C U Hellen; E Wimmer
Journal:  J Virol       Date:  1991-11       Impact factor: 5.103

8.  Interaction of a cellular 57-kilodalton protein with the internal translation initiation site of foot-and-mouth disease virus.

Authors:  N Luz; E Beck
Journal:  J Virol       Date:  1991-12       Impact factor: 5.103

9.  Cell proteins bind to a linear polypyrimidine-rich sequence within the 5'-untranslated region of rhinovirus 14 RNA.

Authors:  I A Rojas-Eisenring; M Cajero-Juarez; R M del Angel
Journal:  J Virol       Date:  1995-11       Impact factor: 5.103

10.  Poliovirus infection enhances the formation of two ribonucleoprotein complexes at the 3' end of viral negative-strand RNA.

Authors:  H H Roehl; B L Semler
Journal:  J Virol       Date:  1995-05       Impact factor: 5.103
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