Literature DB >> 21648390

Templated construction of a Zn-selective protein dimerization motif.

Eric N Salgado1, Jeffrey D Brodin, Magnus M To, F Akif Tezcan.   

Abstract

Here, we report that the approach of metal-templated ligand synthesis can be applied to construct a dimeric protein assembly ((BMOE)RIDC1(2)), which is stabilized by noncovalent interactions and flexible covalent cross-linkers around the Zn templates. Despite its flexibility, (BMOE)RIDC1(2) selectively binds Zn(II) over other divalent metals and undergoes dimerization upon metal binding. Such simultaneous fulfillment of plasticity and selectivity is a hallmark of cellular signaling events that involve ligand/metal-induced protein dimerization.
© 2011 American Chemical Society

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Year:  2011        PMID： 21648390      PMCID： PMC6911222          DOI： 10.1021/ic200746m

Source DB:  PubMed          Journal:  Inorg Chem        ISSN： 0020-1669            Impact factor:   5.165


  36 in total

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  8 in total

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