OBJECTIVE: We undertook a systematic review to assess normative levels of vitamin D in early pregnancy and association with subsequent pregnancy outcomes. STUDY DESIGN: Medline and Embase databases and reference lists were searched. Inclusion criteria were pregnant populations, blood sample taken during the first trimester, and serum hydroxyvitamin D levels assessed. RESULTS: Eighteen studies reported vitamin D levels in first trimester (n = 11-3730), and 5 examined pregnancy outcomes. Mean vitamin D concentrations differed when stratified by ethnicity: white (mean [SD]: 29.4 [11.7] to 73.1 [27.1] nmol/L) and nonwhite (15.2 [12.1] to 43 [12] nmol/L). Most studies used general population cut points to define deficiency and found a large proportion of women deficient. Two articles examined risk of preeclampsia and reported differing findings, whereas 2 of 3 found low levels associated with increased risk of small-for-gestational age births. CONCLUSION: There is no clear definition of vitamin D deficiency in pregnancy and insufficient evidence to suggest low vitamin D levels in early pregnancy are associated with adverse pregnancy outcomes.
OBJECTIVE: We undertook a systematic review to assess normative levels of vitamin D in early pregnancy and association with subsequent pregnancy outcomes. STUDY DESIGN: Medline and Embase databases and reference lists were searched. Inclusion criteria were pregnant populations, blood sample taken during the first trimester, and serum hydroxyvitamin D levels assessed. RESULTS: Eighteen studies reported vitamin D levels in first trimester (n = 11-3730), and 5 examined pregnancy outcomes. Mean vitamin D concentrations differed when stratified by ethnicity: white (mean [SD]: 29.4 [11.7] to 73.1 [27.1] nmol/L) and nonwhite (15.2 [12.1] to 43 [12] nmol/L). Most studies used general population cut points to define deficiency and found a large proportion of women deficient. Two articles examined risk of preeclampsia and reported differing findings, whereas 2 of 3 found low levels associated with increased risk of small-for-gestational age births. CONCLUSION: There is no clear definition of vitamin Ddeficiency in pregnancy and insufficient evidence to suggest low vitamin D levels in early pregnancy are associated with adverse pregnancy outcomes.
Authors: Luisa A Wetta; Joseph R Biggio; Suzanne Cliver; Adi Abramovici; Stephen Barnes; Alan T N Tita Journal: Am J Perinatol Date: 2013-09-10 Impact factor: 1.862
Authors: J Wen; Q Hong; L Zhu; P Xu; Z Fu; X Cui; L You; X Wang; T Wu; H Ding; Y Dai; C Ji; X Guo Journal: Int J Obes (Lond) Date: 2016-12-23 Impact factor: 5.095
Authors: David A Fried; Jane Rhyu; Karen Odato; Heather Blunt; Margaret R Karagas; Diane Gilbert-Diamond Journal: Nutr Rev Date: 2016-04-15 Impact factor: 7.110
Authors: Eynav Elgavish Accortt; Christine Dunkel Schetter; Rosalind M Peters; Andrea E Cassidy-Bushrow Journal: Arch Womens Ment Health Date: 2015-09-26 Impact factor: 3.633