Literature DB >> 2160946

DNA cloning and organization of the Staphylococcus aureus gyrA and gyrB genes: close homology among gyrase proteins and implications for 4-quinolone action and resistance.

R Hopewell1, M Oram, R Briesewitz, L M Fisher.   

Abstract

Staphylococcus aureus gyrA and gyrB genes, which encode the DNA gyrase A and B proteins, have been isolated and found to map contiguously. DNA sequence analysis revealed close homology between the S. aureus gyrase subunits and their counterparts in Bacillus subtilis and Escherichia coli, including several conserved amino acid residues whose substitution in E. coli confers resistance to 4-quinolones. These results are discussed in regard to quinolone resistance mechanisms in S. aureus.

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Year:  1990        PMID： 2160946      PMCID： PMC209162          DOI： 10.1128/jb.172.6.3481-3484.1990

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  35 in total

1.  Colony hybridization: a method for the isolation of cloned DNAs that contain a specific gene.

Authors:  M Grunstein; D S Hogness
Journal:  Proc Natl Acad Sci U S A       Date:  1975-10       Impact factor: 11.205

2.  Detection of specific sequences among DNA fragments separated by gel electrophoresis.

Authors:  E M Southern
Journal:  J Mol Biol       Date:  1975-11-05       Impact factor: 5.469

3.  DNA gyrase: an enzyme that introduces superhelical turns into DNA.

Authors:  M Gellert; K Mizuuchi; M H O'Dea; H A Nash
Journal:  Proc Natl Acad Sci U S A       Date:  1976-11       Impact factor: 11.205

4.  Improved estimation of secondary structure in ribonucleic acids.

Authors:  I Tinoco; P N Borer; B Dengler; M D Levin; O C Uhlenbeck; D M Crothers; J Bralla
Journal:  Nat New Biol       Date:  1973-11-14

5.  Purification of subunits of Escherichia coli DNA gyrase and reconstitution of enzymatic activity.

Authors:  N P Higgins; C L Peebles; A Sugino; N R Cozzarelli
Journal:  Proc Natl Acad Sci U S A       Date:  1978-04       Impact factor: 11.205

6.  Mechanism of action of nalidixic acid on Escherichia coli. 3. Conditions required for lethality.

Authors:  W H Deitz; T M Cook; W A Goss
Journal:  J Bacteriol       Date:  1966-02       Impact factor: 3.490

7.  DNA gyrase: subunit structure and ATPase activity of the purified enzyme.

Authors:  K Mizuuchi; M H O'Dea; M Gellert
Journal:  Proc Natl Acad Sci U S A       Date:  1978-12       Impact factor: 11.205

8.  Nalidixic acid resistance: a second genetic character involved in DNA gyrase activity.

Authors:  M Gellert; K Mizuuchi; M H O'Dea; T Itoh; J I Tomizawa
Journal:  Proc Natl Acad Sci U S A       Date:  1977-11       Impact factor: 11.205

9.  DNA sequencing with chain-terminating inhibitors.

Authors:  F Sanger; S Nicklen; A R Coulson
Journal:  Proc Natl Acad Sci U S A       Date:  1977-12       Impact factor: 11.205

10.  MECHANISM OF ACTION OF NALIDIXIC ACID ON ESCHERICHIA COLI.II. INHIBITION OF DEOXYRIBONUCLEIC ACID SYNTHESIS.

Authors:  W A GOSS; W H DEITZ; T M COOK
Journal:  J Bacteriol       Date:  1965-04       Impact factor: 3.490
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  33 in total

1.  Sequence analysis of the gyrA and parC homologues of a wild-type strain of Vibrio parahaemolyticus and its fluoroquinolone-resistant mutants.

Authors:  J Okuda; E Hayakawa; M Nishibuchi; T Nishino
Journal:  Antimicrob Agents Chemother       Date:  1999-05       Impact factor: 5.191

2.  Detection of gyrA gene mutations associated with ciprofloxacin resistance in methicillin-resistant Staphylococcus aureus: analysis by polymerase chain reaction and automated direct DNA sequencing.

Authors:  J J Goswitz; K E Willard; C E Fasching; L R Peterson
Journal:  Antimicrob Agents Chemother       Date:  1992-05       Impact factor: 5.191

3.  Pre-boiling high GC content, mixed primers with 3' complementation allows the successful PCR amplification of Pseudomonas aeruginosa DNA.

Authors:  A Kureishi; L E Bryan
Journal:  Nucleic Acids Res       Date:  1992-03-11       Impact factor: 16.971

4.  New nucleotide sequence data on the EMBL File Server.

Authors: 
Journal:  Nucleic Acids Res       Date:  1991-06-11       Impact factor: 16.971

Review 5.  Genotypic approach to the study of bacterial resistance to antibiotics.

Authors:  P Courvalin
Journal:  Antimicrob Agents Chemother       Date:  1991-06       Impact factor: 5.191

6.  4-Quinolone resistance mutations in the DNA gyrase of Escherichia coli clinical isolates identified by using the polymerase chain reaction.

Authors:  M Oram; L M Fisher
Journal:  Antimicrob Agents Chemother       Date:  1991-02       Impact factor: 5.191

7.  Nucleotide sequence of the gyrB gene of Pseudomonas putida.

Authors:  R E Parales; C S Harwood
Journal:  Nucleic Acids Res       Date:  1990-10-11       Impact factor: 16.971

8.  Mechanisms of clinical resistance to fluoroquinolones in Staphylococcus aureus.

Authors:  N Nakanishi; S Yoshida; H Wakebe; M Inoue; T Yamaguchi; S Mitsuhashi
Journal:  Antimicrob Agents Chemother       Date:  1991-12       Impact factor: 5.191

9.  Ciprofloxacin resistance in coagulase-positive and -negative staphylococci: role of mutations at serine 84 in the DNA gyrase A protein of Staphylococcus aureus and Staphylococcus epidermidis.

Authors:  S Sreedharan; L R Peterson; L M Fisher
Journal:  Antimicrob Agents Chemother       Date:  1991-10       Impact factor: 5.191

10.  Quinolone resistance mutations in topoisomerase IV: relationship to the flqA locus and genetic evidence that topoisomerase IV is the primary target and DNA gyrase is the secondary target of fluoroquinolones in Staphylococcus aureus.

Authors:  E Y Ng; M Trucksis; D C Hooper
Journal:  Antimicrob Agents Chemother       Date:  1996-08       Impact factor: 5.191
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