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Literature DB >> 21593786

Human cancers express mutator phenotypes: origin, consequences and targeting.

Abstract

Recent data on DNA sequencing of human tumours have established that cancer cells contain thousands of mutations. These data support the concept that cancer cells express a mutator phenotype. This Perspective considers the evidence supporting the mutator phenotype hypothesis, the origin and consequences of a mutator phenotype, the implications for personalized medicine and the feasibility of ablating tumours by error catastrophe.

Entities: Chemical Disease Gene Mutation Species

Mesh：

Year: 2011 PMID： 21593786 PMCID： PMC4007007 DOI： 10.1038/nrc3063

Source DB: PubMed Journal: Nat Rev Cancer ISSN： 1474-175X Impact factor: 60.716

114 in total

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Journal: Nat Methods Date: 2005-03-23 Impact factor: 28.547

Review 2. DNA polymerases and human disease.

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3. Negative clonal selection in tumor evolution.

Authors: Robert A Beckman; Lawrence A Loeb
Journal: Genetics Date: 2005-09-02 Impact factor: 4.562

4. Efficiency of carcinogenesis with and without a mutator mutation.

Authors: Robert A Beckman; Lawrence A Loeb
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5. Frequent mutations of chromatin remodeling gene ARID1A in ovarian clear cell carcinoma.

Authors: Siân Jones; Tian-Li Wang; Ie-Ming Shih; Tsui-Lien Mao; Kentaro Nakayama; Richard Roden; Ruth Glas; Dennis Slamon; Luis A Diaz; Bert Vogelstein; Kenneth W Kinzler; Victor E Velculescu; Nickolas Papadopoulos
Journal: Science Date: 2010-09-08 Impact factor: 47.728

6. DNMT3A mutations in acute myeloid leukemia.

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Journal: N Engl J Med Date: 2010-11-10 Impact factor: 91.245

Review 7. Mechanistic data and cancer risk assessment: the need for quantitative molecular endpoints.

Authors: R Julian Preston
Journal: Environ Mol Mutagen Date: 2005 Mar-Apr Impact factor: 3.216

8. A comprehensive catalogue of somatic mutations from a human cancer genome.

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9. Aneuploidy vs. gene mutation hypothesis of cancer: recent study claims mutation but is found to support aneuploidy.

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Journal: Proc Natl Acad Sci U S A Date: 2000-03-28 Impact factor: 11.205

10. The genomic complexity of primary human prostate cancer.

Authors: Michael F Berger; Michael S Lawrence; Francesca Demichelis; Yotam Drier; Kristian Cibulskis; Andrey Y Sivachenko; Andrea Sboner; Raquel Esgueva; Dorothee Pflueger; Carrie Sougnez; Robert Onofrio; Scott L Carter; Kyung Park; Lukas Habegger; Lauren Ambrogio; Timothy Fennell; Melissa Parkin; Gordon Saksena; Douglas Voet; Alex H Ramos; Trevor J Pugh; Jane Wilkinson; Sheila Fisher; Wendy Winckler; Scott Mahan; Kristin Ardlie; Jennifer Baldwin; Jonathan W Simons; Naoki Kitabayashi; Theresa Y MacDonald; Philip W Kantoff; Lynda Chin; Stacey B Gabriel; Mark B Gerstein; Todd R Golub; Matthew Meyerson; Ashutosh Tewari; Eric S Lander; Gad Getz; Mark A Rubin; Levi A Garraway
Journal: Nature Date: 2011-02-10 Impact factor: 49.962

172 in total

Review 1. Systems cancer medicine: towards realization of predictive, preventive, personalized and participatory (P4) medicine.

Authors: Q Tian; N D Price; L Hood
Journal: J Intern Med Date: 2012-02 Impact factor: 8.989

Review 2. Molecular prescreening to select patient population in early clinical trials.

Authors: Jordi Rodón; Cristina Saura; Rodrigo Dienstmann; Ana Vivancos; Santiago Ramón y Cajal; José Baselga; Josep Tabernero
Journal: Nat Rev Clin Oncol Date: 2012-04-03 Impact factor: 66.675

Review 3. JAK2 and genomic instability in the myeloproliferative neoplasms: a case of the chicken or the egg?

Authors: Linda M Scott; Vivienne I Rebel
Journal: Am J Hematol Date: 2012-05-28 Impact factor: 10.047

4. Tumor Heterogeneity--A 'Contemporary Concept' Founded on Historical Insights and Predictions.

Authors: Danny R Welch
Journal: Cancer Res Date: 2016-01-03 Impact factor: 12.701

5. R-loop-mediated genome instability in mRNA cleavage and polyadenylation mutants.

Authors: Peter C Stirling; Yujia A Chan; Sean W Minaker; Maria J Aristizabal; Irene Barrett; Payal Sipahimalani; Michael S Kobor; Philip Hieter
Journal: Genes Dev Date: 2012-01-15 Impact factor: 11.361

6. Sirtuin-3 (SIRT3) and the Hallmarks of Cancer.

Authors: Turki Y Alhazzazi; Pachiyappan Kamarajan; Eric Verdin; Yvonne L Kapila
Journal: Genes Cancer Date: 2013-03

7. Biomarkers of oxidatively induced DNA damage in dreissenid mussels: A genotoxicity assessment tool for the Laurentian Great Lakes.

Authors: Pawel Jaruga; Erdem Coskun; Kimani Kimbrough; Annie Jacob; W Edward Johnson; Miral Dizdaroglu
Journal: Environ Toxicol Date: 2017-06-01 Impact factor: 4.119

8. Whole-exome sequencing characterizes the landscape of somatic mutations and copy number alterations in adrenocortical carcinoma.

Authors: C Christofer Juhlin; Gerald Goh; James M Healy; Annabelle L Fonseca; Ute I Scholl; Adam Stenman; John W Kunstman; Taylor C Brown; John D Overton; Shrikant M Mane; Carol Nelson-Williams; Martin Bäckdahl; Anna-Carinna Suttorp; Matthias Haase; Murim Choi; Joseph Schlessinger; David L Rimm; Anders Höög; Manju L Prasad; Reju Korah; Catharina Larsson; Richard P Lifton; Tobias Carling
Journal: J Clin Endocrinol Metab Date: 2014-12-09 Impact factor: 5.958

Review 9. How many molecular subtypes? Implications of the unique tumor principle in personalized medicine.

Authors: Shuji Ogino; Charles S Fuchs; Edward Giovannucci
Journal: Expert Rev Mol Diagn Date: 2012-07 Impact factor: 5.225

10. Decreased Mitochondrial Mutagenesis during Transformation of Human Breast Stem Cells into Tumorigenic Cells.

Authors: Eun Hyun Ahn; Seung Hyuk Lee; Joon Yup Kim; Chia-Cheng Chang; Lawrence A Loeb
Journal: Cancer Res Date: 2016-05-17 Impact factor: 12.701