Literature DB >> 215922

On spare beta-adrenoceptors of inotropic effect of catecholamines in kitten ventricle.

A J Kaumann.   

Abstract

Beta-Adrenoceptors of ventricular membranes of kitten heart were labelled reversibly with (--)-3H-propranolol (binding constant 6nM). Bound (--)-3H-propranolol was displaced with beta-adrenoceptor blocking agents and catecholamines. Displacement constants KD(M) of the blockers were of the same of magnitude as their constants KB obtained from the antagonism of inotropic effects of catecholamines in papillary muscles. KD's of catecholamines were, however, 2 orders of magnitude larger than concentrations causing half maximal inotropic effects, indicating large spare beta-adrenoceptor capacity.

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Year:  1978        PMID： 215922     DOI： 10.1007/bf00508277

Source DB:  PubMed          Journal:  Naunyn Schmiedebergs Arch Pharmacol        ISSN： 0028-1298            Impact factor:   3.000


  23 in total

1.  Binding of iodinated beta adrenergic antagonists to proteins derived from rat heart.

Authors:  T K Harden; B B Wolfe; P B Molinoff
Journal:  Mol Pharmacol       Date:  1976-01       Impact factor: 4.436

2.  Use of (-)-[3H]dihydroalprenolol to study beta adrenergic receptor-adenylate cyclase coupling in C6 glioma cells: role of 5'-guanylylimidodiphosphate.

Authors:  M Lucas; J Bockaert
Journal:  Mol Pharmacol       Date:  1977-03       Impact factor: 4.436

3.  Apparent equilibrium constant between beta-adrenoceptors and a competitive antagonist on a cultured pacemaker cell of mammalian heart.

Authors:  A J Kaumann; R Wittmann
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1975       Impact factor: 3.000

4.  Potentiation of the effects of isoprenaline and noradrenaline by hydrocortisone in cat heart muscle.

Authors:  A J Kaumann
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1972       Impact factor: 3.000

5.  Adrenergic receptors in heart muscle: relations among factors influencing the sensitivity of the cat papillary muscle to catecholamines.

Authors:  A J Kaumann
Journal:  J Pharmacol Exp Ther       Date:  1970-06       Impact factor: 4.030

6.  Mathematical analysis of concentration-response relationships. Method for the evaluation of the ED50 and the number of binding sites per receptor molecule using the logit transformation.

Authors:  D Hafner; E Heinen; E Noack
Journal:  Arzneimittelforschung       Date:  1977

7.  Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction.

Authors:  Y Cheng; W H Prusoff
Journal:  Biochem Pharmacol       Date:  1973-12-01       Impact factor: 5.858

8.  Beta-Adrenergic receptor interactions. Direct comparison of receptor interaction and biological activity.

Authors:  E M Brown; S A Fedak; C J Woodard; G D Aurbach
Journal:  J Biol Chem       Date:  1976-03-10       Impact factor: 5.157

9.  Relaxation of heart muscle by catecholamines and by dibutyryl cyclic adenosine 3',5'-monophosphate. Similarity of beta-adrenoceptors mediating contractile and relaxant effects of catecholamines in kitten pipillary muscle.

Authors:  A J Kaumann
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1977-02       Impact factor: 3.000

10.  Some quantitative uses of drug antagonists.

Authors:  O ARUNLAKSHANA; H O SCHILD
Journal:  Br J Pharmacol Chemother       Date:  1959-03
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  31 in total

1.  A comparison of the influence of N-isopropyl and N-tert butyl substituents on the affinity of ligands for sinoatrial beta-adrenoceptors in rat atria and beta-adrenoceptors coupled to the adenylyl cyclase in kitten ventricle.

Authors:  A J Kaumann; T H Morris; L Birnbaumer
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1979-05       Impact factor: 3.000

2.  A model for the interaction of competitive antagonists with two receptor-subtypes characterized by a Schild-plot with apparent slope unity. Agonist-dependent enantiomeric affinity ratios for bupranolol in tracheae but not in right atria of guinea pigs.

Authors:  H Lemoine; A J Kaumann
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1983-03       Impact factor: 3.000

3.  On equilibrium dissociation constants for complexes of drug-receptor subtypes. Selective and non-selective interactions of partial agonists with two plausible beta-adrenoceptor subtypes mediating positive chronotropic effects of (-)-isoprenaline in kitten atria.

Authors:  A J Kaumann; M Marano
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1982-02       Impact factor: 3.000

4.  Cultured heart cells as a model for beta-adrenoceptors in a heart pacemaker. Chronotropic spare beta-adrenoceptors and spare adenylyl cyclase for (-)-isoprenaline but not for (-)-dichloroisoprenaline in rat cardiocytes.

Authors:  A J Kaumann
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1982-08       Impact factor: 3.000

5.  In kitten ventricular myocardium, the inotropic potency of an agonist is determined by both its intrinsic activity for the adenylyl cyclase and its affinity for the beta-adrenoceptors.

Authors:  A J Kaumann
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1981-08       Impact factor: 3.000

6.  Direct labelling of myocardial beta 1-adrenoceptors. Comparison of binding affinity of 3H-(-)-bisoprolol with its blocking potency.

Authors:  A J Kaumann; H Lemoine
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1985-10       Impact factor: 3.000

7.  Cardiostimulatory effects of prenalterol, a beta-1 adrenoceptor partial agonist, in vivo and in vitro. Correlation between physiological effects and adenylate cyclase activity.

Authors:  A Hedberg; E Carlsson; E Fellenius; B Lundgren
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1982-02       Impact factor: 3.000

8.  Evidence that (+)-bupranolol interacts directly with myocardial beta-adrenoceptors. Control of optical purity with differential thermal analysis.

Authors:  W Wächter; U Münch; H Lemoine; A J Kaumann
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1980-08       Impact factor: 3.000

9.  Effects of in vivo treatment with isoprenaline or prenalterol on beta-adrenoceptor mechanisms in the heart and soleus muscle of the cat.

Authors:  A Hedberg; H Mattsson; V Nerme; E Carlsson
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1984-03       Impact factor: 3.000

Review 10.  Some aspects of heart beta adrenoceptor function.

Authors:  A J Kaumann
Journal:  Cardiovasc Drugs Ther       Date:  1991-06       Impact factor: 3.727
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