Literature DB >> 235102

Apparent equilibrium constant between beta-adrenoceptors and a competitive antagonist on a cultured pacemaker cell of mammalian heart.

A J Kaumann, R Wittmann.   

Abstract

Heart cells from newborn rats and kittens were cultured. In both species the rate of pacemaker activity of single, cultured cells was increased by low concentrations of catecholamines. Tthe beta-adrenoceptor blocker (minus)-KL255 antagonized competitively the effects of both, (minus)-noradrenaline and (minus)-isoprenaline. A mean equilibrium constant of 3.6 times 10-10M between (minus)-KL255 and beta-adrenoceptors of single cells was estimated.

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Year:  1975        PMID： 235102     DOI： 10.1007/bf00632635

Source DB:  PubMed          Journal:  Naunyn Schmiedebergs Arch Pharmacol        ISSN： 0028-1298            Impact factor:   3.000


  15 in total

1.  RHYTHMIC AND ARRHYTHMIC CONTRACTILE ACTIVITY OF SINGLE MYOCARDIAL CELLS CULTURED IN VITRO.

Authors:  A WOLLENBERGER
Journal:  Circ Res       Date:  1964-11       Impact factor: 17.367

2.  Rapid proliferation of sublines of NCTC clone 929 (strain L) mouse cells in a simple chemically defined medium (MB 752/1).

Authors:  C WAYMOUTH
Journal:  J Natl Cancer Inst       Date:  1959-05       Impact factor: 13.506

3.  Comparative effects of some cardioactive agents on automaticity of cultured heart cells.

Authors:  G B Boder; I S Johnson
Journal:  J Mol Cell Cardiol       Date:  1972-10       Impact factor: 5.000

4.  Potentiation of the effects of isoprenaline and noradrenaline by hydrocortisone in cat heart muscle.

Authors:  A J Kaumann
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1972       Impact factor: 3.000

5.  Autonomic receptor mechanisms in embryonic chick myocardial cell cultures.

Authors:  R J Ertel; D E Clarke; J C Chao; F R Franke
Journal:  J Pharmacol Exp Ther       Date:  1971-07       Impact factor: 4.030

6.  [Mechanical and electrical activity of isolated embryonic heart muscle cells in cell cultures].

Authors:  R Kaufmann; H Tritthart; S Rodenroth; B Rost
Journal:  Pflugers Arch       Date:  1969       Impact factor: 3.657

7.  Adrenergic receptors in heart muscle: relations among factors influencing the sensitivity of the cat papillary muscle to catecholamines.

Authors:  A J Kaumann
Journal:  J Pharmacol Exp Ther       Date:  1970-06       Impact factor: 4.030

8.  Proceedings: Adrenergic receptors in heart muscle: similarity of apparent affinities of beta-blockers for receptors mediating adenyl-cyclase activity, inotropic and chronotropic effects of catecholamines.

Authors:  A J Kaumann; L Birnbaumer
Journal:  Acta Physiol Lat Am       Date:  1973

9.  Uptake of propranolol by isolated guinea-pig atria.

Authors:  L T Potter
Journal:  J Pharmacol Exp Ther       Date:  1967-01       Impact factor: 4.030

10.  Some quantitative uses of drug antagonists.

Authors:  O ARUNLAKSHANA; H O SCHILD
Journal:  Br J Pharmacol Chemother       Date:  1959-03
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  8 in total

1.  On spare beta-adrenoceptors of inotropic effect of catecholamines in kitten ventricle.

Authors:  A J Kaumann
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1978-11       Impact factor: 3.000

2.  Desensitization of kitten atria to chronotropic, inotropic and adenylyl cyclase stimulating effects of (-)isoprenaline.

Authors:  A J Kaumann; L Birnbaumer
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1976-05       Impact factor: 3.000

3.  Cultured heart cells as a model for beta-adrenoceptors in a heart pacemaker. Chronotropic spare beta-adrenoceptors and spare adenylyl cyclase for (-)-isoprenaline but not for (-)-dichloroisoprenaline in rat cardiocytes.

Authors:  A J Kaumann
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1982-08       Impact factor: 3.000

4.  Comparative assessment of beta-adrenoceptor blocking agents as simple competitive antagonists in isolated heart muscle: similarity of inotropic and chronotropic blocking potencies against isoproterenol.

Authors:  A J Kaumann; T K McInerny; D P Gilmour; J R Blinks
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1980-04       Impact factor: 3.000

5.  3H-(-)-Bupranolol, a new beta-adrenoceptor radioligand: characterization of its binding to kitten heart beta-adrenoceptors.

Authors:  T H Morris; K Sandrock; A J Kaumann
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1981-08       Impact factor: 3.000

6.  A novel analysis of concentration-dependence of partial agonism Ring-demethylation of bupranolol results in a high affinity partial agonist (K 105) for myocardial and tracheal beta-adrenoceptors.

Authors:  H Lemoine; A J Kaumann
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1982-08       Impact factor: 3.000

7.  Relaxation of heart muscle by catecholamines and by dibutyryl cyclic adenosine 3',5'-monophosphate. Similarity of beta-adrenoceptors mediating contractile and relaxant effects of catecholamines in kitten pipillary muscle.

Authors:  A J Kaumann
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1977-02       Impact factor: 3.000

8.  Activation of myocardial beta-adrenoceptors by the nitrogen-free low affinity ligand 3',4'-dihydroxy-alpha-methylpropiophenone (U-0521).

Authors:  A J Kaumann; R Wittmann; L Birnbaumer; B H Hoppe
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1977-02       Impact factor: 3.000
  8 in total

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