Literature DB >> 21586315

SIRT3 and cancer: tumor promoter or suppressor?

Turki Y Alhazzazi1, Pachiyappan Kamarajan, Eric Verdin, Yvonne L Kapila.   

Abstract

Sirtuins (SIRT1-7), the mammalian homologues of the Sir2 gene in yeast, have emerging roles in age-related diseases, such as cardiac hypertrophy, diabetes, obesity, and cancer. However, the role of several sirtuin family members, including SIRT1 and SIRT3, in cancer has been controversial. The aim of this review is to explore and discuss the seemingly dichotomous role of SIRT3 in cancer biology with particular emphasis on its potential role as a tumor promoter and tumor suppressor. This review will also discuss the potential role of SIRT3 as a novel therapeutic target to treat cancer. 2011 Elsevier B.V. All rights reserved.

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Year:  2011        PMID： 21586315      PMCID： PMC3129516          DOI： 10.1016/j.bbcan.2011.04.004

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  130 in total

1.  Characterization of the murine SIRT3 mitochondrial localization sequence and comparison of mitochondrial enrichment and deacetylase activity of long and short SIRT3 isoforms.

Authors:  Jianjun Bao; Zhongping Lu; Joshua J Joseph; Darin Carabenciov; Christopher C Dimond; Liyan Pang; Leigh Samsel; J Philip McCoy; Jaime Leclerc; Phuongmai Nguyen; David Gius; Michael N Sack
Journal:  J Cell Biochem       Date:  2010-05       Impact factor: 4.429

2.  Isocitrate dehydrogenase mutations may be a protective mechanism in glioma patients.

Authors:  Jian Zhu; Jianling Zuo; Qinian Xu; Xiuyun Wang; Zhong Wang; Dai Zhou
Journal:  Med Hypotheses       Date:  2011-02-01       Impact factor: 1.538

Review 3.  Targeting anoikis resistance in prostate cancer metastasis.

Authors:  Shinichi Sakamoto; Natasha Kyprianou
Journal:  Mol Aspects Med       Date:  2010-02-11

4.  SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production.

Authors:  Tadahiro Shimazu; Matthew D Hirschey; Lan Hua; Kristin E Dittenhafer-Reed; Bjoern Schwer; David B Lombard; Yu Li; Jakob Bunkenborg; Frederick W Alt; John M Denu; Matthew P Jacobson; Eric Verdin
Journal:  Cell Metab       Date:  2010-12-01       Impact factor: 27.287

Review 5.  Targeting glucose metabolism: an emerging concept for anticancer therapy.

Authors:  Brijesh M Madhok; Sashidhar Yeluri; Sarah L Perry; Thomas A Hughes; David G Jayne
Journal:  Am J Clin Oncol       Date:  2011-12       Impact factor: 2.339

6.  SIRT3 is pro-apoptotic and participates in distinct basal apoptotic pathways.

Authors:  Simon J Allison; Jo Milner
Journal:  Cell Cycle       Date:  2007-08-10       Impact factor: 4.534

7.  Exogenous NAD blocks cardiac hypertrophic response via activation of the SIRT3-LKB1-AMP-activated kinase pathway.

Authors:  Vinodkumar B Pillai; Nagalingam R Sundaresan; Gene Kim; Madhu Gupta; Senthilkumar B Rajamohan; Jyothish B Pillai; Sadhana Samant; P V Ravindra; Ayman Isbatan; Mahesh P Gupta
Journal:  J Biol Chem       Date:  2009-11-24       Impact factor: 5.157

8.  Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice.

Authors:  Rui-Hong Wang; Kundan Sengupta; Cuiling Li; Hyun-Seok Kim; Liu Cao; Cuiying Xiao; Sangsoo Kim; Xiaoling Xu; Yin Zheng; Beverly Chilton; Rong Jia; Zhi-Ming Zheng; Ettore Appella; Xin Wei Wang; Thomas Ried; Chu-Xia Deng
Journal:  Cancer Cell       Date:  2008-10-07       Impact factor: 31.743

Review 9.  Sirtuins in mammals: insights into their biological function.

Authors:  Shaday Michan; David Sinclair
Journal:  Biochem J       Date:  2007-05-15       Impact factor: 3.857

10.  Targeting apoptosis to overcome cisplatin resistance: a translational study in head and neck cancer.

Authors:  Joshua A Bauer; Bhavna Kumar; Kitrina G Cordell; Mark E Prince; Huong H Tran; Gregory T Wolf; Douglas B Chepeha; Theodoros N Teknos; Steven Wang; Avraham Eisbruch; Christina I Tsien; Susan G Urba; Francis P Worden; Julia Lee; Kent A Griffith; Jeremy M G Taylor; Nisha D'Silva; Shaomeng J Wang; Keith G Wolter; Bradley Henson; Susan G Fisher; Thomas E Carey; Carol R Bradford
Journal:  Int J Radiat Oncol Biol Phys       Date:  2007       Impact factor: 7.038
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  74 in total

1.  A Novel Sirtuin-3 Inhibitor, LC-0296, Inhibits Cell Survival and Proliferation, and Promotes Apoptosis of Head and Neck Cancer Cells.

Authors:  Turki Y Alhazzazi; Pachiyappan Kamarajan; Yanli Xu; Teng Ai; Liqiang Chen; Eric Verdin; Yvonne L Kapila
Journal:  Anticancer Res       Date:  2016-01       Impact factor: 2.480

2.  Sirtuin-3 (SIRT3) and the Hallmarks of Cancer.

Authors:  Turki Y Alhazzazi; Pachiyappan Kamarajan; Eric Verdin; Yvonne L Kapila
Journal:  Genes Cancer       Date:  2013-03

Review 3.  Sirtuins and the Metabolic Hurdles in Cancer.

Authors:  Natalie J German; Marcia C Haigis
Journal:  Curr Biol       Date:  2015-06-29       Impact factor: 10.834

4.  SIRT3 expression as a biomarker for better prognosis in gastric cancer.

Authors:  Kuo-Hung Huang; Chia-Chi Hsu; Wen-Liang Fang; Chin-Wen Chi; Ming-Ta Sung; Hwa-Li Kao; Anna Fen-Yau Li; Pen-Hui Yin; Muh-Hwa Yang; Hsin-Chen Lee
Journal:  World J Surg       Date:  2014-04       Impact factor: 3.352

5.  SirT3 regulates the mitochondrial unfolded protein response.

Authors:  Luena Papa; Doris Germain
Journal:  Mol Cell Biol       Date:  2013-12-09       Impact factor: 4.272

6.  Quantifying Competition among Mitochondrial Protein Acylation Events Induced by Ethanol Metabolism.

Authors:  Hadi R Ali; Mohammed A Assiri; Peter S Harris; Cole R Michel; Youngho Yun; John O Marentette; Frank K Huynh; David J Orlicky; Colin T Shearn; Laura M Saba; Richard Reisdorph; Nichole Reisdorph; Matthew D Hirschey; Kristofer S Fritz
Journal:  J Proteome Res       Date:  2019-01-31       Impact factor: 4.466

7.  Sirtuin 3 inhibits hepatocellular carcinoma growth through the glycogen synthase kinase-3β/BCL2-associated X protein-dependent apoptotic pathway.

Authors:  C-L Song; H Tang; L-K Ran; B C B Ko; Z-Z Zhang; X Chen; J-H Ren; N-N Tao; W-Y Li; A-L Huang; J Chen
Journal:  Oncogene       Date:  2015-04-27       Impact factor: 9.867

8.  Geroncogenesis: metabolic changes during aging as a driver of tumorigenesis.

Authors:  Lindsay E Wu; Ana P Gomes; David A Sinclair
Journal:  Cancer Cell       Date:  2014-01-13       Impact factor: 31.743

Review 9.  The sirtuin family's role in aging and age-associated pathologies.

Authors:  Jessica A Hall; John E Dominy; Yoonjin Lee; Pere Puigserver
Journal:  J Clin Invest       Date:  2013-03-01       Impact factor: 14.808

10.  Germline copy number variation of genes involved in chromatin remodelling in families suggestive of Li-Fraumeni syndrome with brain tumours.

Authors:  Juliette Aury-Landas; Gaëlle Bougeard; Hélène Castel; Hector Hernandez-Vargas; Aurélie Drouet; Jean-Baptiste Latouche; Marie-Thérèse Schouft; Claude Férec; Dominique Leroux; Christine Lasset; Isabelle Coupier; Olivier Caron; Zdenko Herceg; Thierry Frebourg; Jean-Michel Flaman
Journal:  Eur J Hum Genet       Date:  2013-04-24       Impact factor: 4.246
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