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Literature DB >> 24434207

Geroncogenesis: metabolic changes during aging as a driver of tumorigenesis.

Lindsay E Wu¹, Ana P Gomes², David A Sinclair³.

Abstract

Why does cancer risk increase as we age? Frequently attributed to the multi-hit hypothesis and the time required to accumulate genomic mutations, this question is a matter of ongoing debate. Here, we propose that the normal decline in oxidative metabolism during aging constitutes an early and important "hit" that drives tumorigenesis. Central to these metabolic changes are the sirtuins, a family of NAD(+)-dependent deacylases that have evolved as coordinators of physiological responses to nutrient intake and energetic demand. Thus, the modulation of sirtuins might be a fruitful approach to reversing the age-related metabolic changes that could underlie tumorigenesis.

Entities: CellLine Chemical Disease Gene Species

Mesh：

Year: 2014 PMID： 24434207 PMCID： PMC3970212 DOI： 10.1016/j.ccr.2013.12.005

Source DB: PubMed Journal: Cancer Cell ISSN： 1535-6108 Impact factor: 31.743

79 in total

1. Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer.

Authors: Daniel Herranz; Maribel Muñoz-Martin; Marta Cañamero; Francisca Mulero; Barbara Martinez-Pastor; Oscar Fernandez-Capetillo; Manuel Serrano
Journal: Nat Commun Date: 2010-04-12 Impact factor: 14.919

2. Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice.

Authors: Jun Yoshino; Kathryn F Mills; Myeong Jin Yoon; Shin-ichiro Imai
Journal: Cell Metab Date: 2011-10-05 Impact factor: 27.287

3. The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop.

Authors: Antje Menssen; Per Hydbring; Karsten Kapelle; Jörg Vervoorts; Joachim Diebold; Bernhard Lüscher; Lars-Gunnar Larsson; Heiko Hermeking
Journal: Proc Natl Acad Sci U S A Date: 2011-12-21 Impact factor: 11.205

4. SIRT6 overexpression induces massive apoptosis in cancer cells but not in normal cells.

Authors: Michael Van Meter; Zhiyong Mao; Vera Gorbunova; Andrei Seluanov
Journal: Cell Cycle Date: 2011-09-15 Impact factor: 4.534

Review 5. SIRT3 and cancer: tumor promoter or suppressor?

Authors: Turki Y Alhazzazi; Pachiyappan Kamarajan; Eric Verdin; Yvonne L Kapila
Journal: Biochim Biophys Acta Date: 2011-05-07

6. Pathways and subcellular compartmentation of NAD biosynthesis in human cells: from entry of extracellular precursors to mitochondrial NAD generation.

Authors: Andrey Nikiforov; Christian Dölle; Marc Niere; Mathias Ziegler
Journal: J Biol Chem Date: 2011-04-19 Impact factor: 5.157

7. SirT3 suppresses hypoxia inducible factor 1α and tumor growth by inhibiting mitochondrial ROS production.

Authors: E L Bell; B M Emerling; S J H Ricoult; L Guarente
Journal: Oncogene Date: 2011-02-28 Impact factor: 9.867

8. The isoenzyme pattern of LDH does not play a physiological role; except perhaps during fast transitions in energy metabolism.

Authors: Bjørn Quistorff; Niels Grunnet
Journal: Aging (Albany NY) Date: 2011-05 Impact factor: 5.682

9. No evidence for a shift in pyruvate kinase PKM1 to PKM2 expression during tumorigenesis.

Authors: Katharina Bluemlein; Nana-Maria Grüning; René G Feichtinger; Hans Lehrach; Barbara Kofler; Markus Ralser
Journal: Oncotarget Date: 2011-05

10. Sirtuin-3 (SIRT3), a novel potential therapeutic target for oral cancer.

Authors: Turki Y Alhazzazi; Pachiyappan Kamarajan; Nam Joo; Jing-Yi Huang; Eric Verdin; Nisha J D'Silva; Yvonne L Kapila
Journal: Cancer Date: 2010-11-29 Impact factor: 6.860

30 in total

Review 1. When stem cells grow old: phenotypes and mechanisms of stem cell aging.

Authors: Michael B Schultz; David A Sinclair
Journal: Development Date: 2016-01-01 Impact factor: 6.868

2. Carnitine palmitoyltransferase 1C regulates cancer cell senescence through mitochondria-associated metabolic reprograming.

Authors: Yongtao Wang; Yixin Chen; Lihuan Guan; Huizheng Zhang; Yaoyao Huang; Caroline H Johnson; Zeming Wu; Frank J Gonzalez; Aiming Yu; Peng Huang; Ying Wang; Shouhui Yang; Pan Chen; Xiaomei Fan; Min Huang; Huichang Bi
Journal: Cell Death Differ Date: 2018-01-09 Impact factor: 15.828

Geroncogenesis: metabolic changes during aging as a driver of tumorigenesis.

1. Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer.

2. Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice.

3. The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop.

4. SIRT6 overexpression induces massive apoptosis in cancer cells but not in normal cells.

Review 5. SIRT3 and cancer: tumor promoter or suppressor?

6. Pathways and subcellular compartmentation of NAD biosynthesis in human cells: from entry of extracellular precursors to mitochondrial NAD generation.

7. SirT3 suppresses hypoxia inducible factor 1α and tumor growth by inhibiting mitochondrial ROS production.

8. The isoenzyme pattern of LDH does not play a physiological role; except perhaps during fast transitions in energy metabolism.

9. No evidence for a shift in pyruvate kinase PKM1 to PKM2 expression during tumorigenesis.

10. Sirtuin-3 (SIRT3), a novel potential therapeutic target for oral cancer.

Review 1. When stem cells grow old: phenotypes and mechanisms of stem cell aging.

2. Carnitine palmitoyltransferase 1C regulates cancer cell senescence through mitochondria-associated metabolic reprograming.

Review 3. Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence.

4. Metformin targets histone acetylation in cancer-prone epithelial cells.

Review 5. SIRT6: Novel Mechanisms and Links to Aging and Disease.

6. Gerometabolites: the pseudohypoxic aging side of cancer oncometabolites.

Review 7. O-GlcNAcylation in Cancer Biology: Linking Metabolism and Signaling.

8. From inflammaging to healthy aging by dietary lifestyle choices: is epigenetics the key to personalized nutrition?

Review 9. Redox control of glutamine utilization in cancer.

Review 10. Regulation of tumor growth and metastasis: the role of tumor microenvironment.