Literature DB >> 2157874

Structure and function of the Epstein-Barr virus BZLF1 protein.

G Packham1, A Economou, C M Rooney, D T Rowe, P J Farrell.   

Abstract

Five DNA-binding sites for the Epstein-Barr virus BZLF1 protein have been identified within three of the early viral promoters, and four of these binding sites contain a consensus AP-1 site. The part of the BZLF1 protein required for sequence-specific DNA binding to one of these AP-1-like sites was identified by deletion mapping. Site-directed mutagenesis of this DNA target suggests that BZLF1 may work partly by overcoming a cellular repressor of viral transcription.

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Year:  1990        PMID： 2157874      PMCID： PMC249368          DOI： 10.1128/JVI.64.5.2110-2116.1990

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  20 in total

1.  Both the rightward and the leftward open reading frames within the BamHI M DNA fragment of Epstein-Barr virus act as trans-activators of gene expression.

Authors:  M O Oguro; N Shimizu; Y Ono; K Takada
Journal:  J Virol       Date:  1987-10       Impact factor: 5.103

2.  Epstein-Barr virus gene expression in P3HR1-superinfected Raji cells.

Authors:  M Biggin; M Bodescot; M Perricaudet; P Farrell
Journal:  J Virol       Date:  1987-10       Impact factor: 5.103

3.  Polymorphic proteins encoded within BZLF1 of defective and standard Epstein-Barr viruses disrupt latency.

Authors:  J Countryman; H Jenson; R Seibl; H Wolf; G Miller
Journal:  J Virol       Date:  1987-12       Impact factor: 5.103

4.  Activation of expression of latent Epstein-Barr herpesvirus after gene transfer with a small cloned subfragment of heterogeneous viral DNA.

Authors:  J Countryman; G Miller
Journal:  Proc Natl Acad Sci U S A       Date:  1985-06       Impact factor: 11.205

5.  trans activation of the latent Epstein-Barr virus (EBV) genome after transfection of the EBV DNA fragment.

Authors:  K Takada; N Shimizu; S Sakuma; Y Ono
Journal:  J Virol       Date:  1986-03       Impact factor: 5.103

6.  Promiscuous trans activation of gene expression by an Epstein-Barr virus-encoded early nuclear protein.

Authors:  P M Lieberman; P O'Hare; G S Hayward; S D Hayward
Journal:  J Virol       Date:  1986-10       Impact factor: 5.103

7.  DNA sequence and expression of the B95-8 Epstein-Barr virus genome.

Authors:  R Baer; A T Bankier; M D Biggin; P L Deininger; P J Farrell; T J Gibson; G Hatfull; G S Hudson; S C Satchwell; C Séguin
Journal:  Nature       Date:  1984 Jul 19-25       Impact factor: 49.962

8.  A new Epstein-Barr virus transactivator, R, induces expression of a cytoplasmic early antigen.

Authors:  J M Hardwick; P M Lieberman; S D Hayward
Journal:  J Virol       Date:  1988-07       Impact factor: 5.103

9.  Both Epstein-Barr virus (EBV)-encoded trans-acting factors, EB1 and EB2, are required to activate transcription from an EBV early promoter.

Authors:  A Chevallier-Greco; E Manet; P Chavrier; C Mosnier; J Daillie; A Sergeant
Journal:  EMBO J       Date:  1986-12-01       Impact factor: 11.598

10.  The Epstein-Barr virus early protein EB1 activates transcription from different responsive elements including AP-1 binding sites.

Authors:  G Urier; M Buisson; P Chambard; A Sergeant
Journal:  EMBO J       Date:  1989-05       Impact factor: 11.598
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  56 in total

1.  Matrix metalloproteinase 9 is induced by the Epstein-Barr virus BZLF1 transactivator.

Authors:  T Yoshizaki; H Sato; S Murono; J S Pagano; M Furukawa
Journal:  Clin Exp Metastasis       Date:  1999-07       Impact factor: 5.150

2.  The Epstein-Barr virus R transactivator (Rta) contains a complex, potent activation domain with properties different from those of VP16.

Authors:  J M Hardwick; L Tse; N Applegren; J Nicholas; M A Veliuona
Journal:  J Virol       Date:  1992-09       Impact factor: 5.103

3.  Repression of CIITA by the Epstein-Barr virus transcription factor Zta is independent of its dimerization and DNA binding.

Authors:  Nicolae Balan; Kay Osborn; Alison J Sinclair
Journal:  J Gen Virol       Date:  2015-12-11       Impact factor: 3.891

4.  Epstein-Barr virus BZLF1 protein binds to mitotic chromosomes.

Authors:  Amy L Adamson
Journal:  J Virol       Date:  2005-06       Impact factor: 5.103

5.  ZEBRA and a Fos-GCN4 chimeric protein differ in their DNA-binding specificities for sites in the Epstein-Barr virus BZLF1 promoter.

Authors:  N Taylor; E Flemington; J L Kolman; R P Baumann; S H Speck; G Miller
Journal:  J Virol       Date:  1991-08       Impact factor: 5.103

6.  Efficient transcription of the Epstein-Barr virus immediate-early BZLF1 and BRLF1 genes requires protein synthesis.

Authors:  E K Flemington; A E Goldfeld; S H Speck
Journal:  J Virol       Date:  1991-12       Impact factor: 5.103

7.  Transcriptional interference between the EBV transcription factors EB1 and R: both DNA-binding and activation domains of EB1 are required.

Authors:  J F Giot; I Mikaelian; M Buisson; E Manet; I Joab; J C Nicolas; A Sergeant
Journal:  Nucleic Acids Res       Date:  1991-03-25       Impact factor: 16.971

8.  Pathways of activation of the Epstein-Barr virus productive cycle.

Authors:  A J Sinclair; M Brimmell; F Shanahan; P J Farrell
Journal:  J Virol       Date:  1991-05       Impact factor: 5.103

9.  Reciprocal antagonism of steroid hormones and BZLF1 in switch between Epstein-Barr virus latent and productive cycle gene expression.

Authors:  A J Sinclair; M Brimmell; P J Farrell
Journal:  J Virol       Date:  1992-01       Impact factor: 5.103

10.  RAZ, an Epstein-Barr virus transdominant repressor that modulates the viral reactivation mechanism.

Authors:  F B Furnari; V Zacny; E B Quinlivan; S Kenney; J S Pagano
Journal:  J Virol       Date:  1994-03       Impact factor: 5.103
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