Literature DB >> 21572414

A genome-wide association study of metabolic traits in human urine.

Karsten Suhre1, Henri Wallaschofski, Johannes Raffler, Nele Friedrich, Robin Haring, Kathrin Michael, Christina Wasner, Alexander Krebs, Florian Kronenberg, David Chang, Christa Meisinger, H-Erich Wichmann, Wolfgang Hoffmann, Henry Völzke, Uwe Völker, Alexander Teumer, Reiner Biffar, Thomas Kocher, Stephan B Felix, Thomas Illig, Heyo K Kroemer, Christian Gieger, Werner Römisch-Margl, Matthias Nauck.   

Abstract

We present a genome-wide association study of metabolic traits in human urine, designed to investigate the detoxification capacity of the human body. Using NMR spectroscopy, we tested for associations between 59 metabolites in urine from 862 male participants in the population-based SHIP study. We replicated the results using 1,039 additional samples of the same study, including a 5-year follow-up, and 992 samples from the independent KORA study. We report five loci with joint P values of association from 3.2 × 10(-19) to 2.1 × 10(-182). Variants at three of these loci have previously been linked with important clinical outcomes: SLC7A9 is a risk locus for chronic kidney disease, NAT2 for coronary artery disease and genotype-dependent response to drug toxicity, and SLC6A20 for iminoglycinuria. Moreover, we identify rs37369 in AGXT2 as the genetic basis of hyper-β-aminoisobutyric aciduria.

Entities:  

Mesh：

Substances：

Year:  2011        PMID： 21572414     DOI： 10.1038/ng.837

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  34 in total

1.  Association between exaggerated blood pressure response to exercise and serum asymmetric dimethylarginine levels.

Authors:  Mehmet Kayrak; Ahmet Bacaksiz; Mehmet Akif Vatankulu; Selim S Ayhan; Alparslan Taner; Ali Unlü; Mehmet Yazici; Mehmet S Ulgen
Journal:  Circ J       Date:  2010-04-27       Impact factor: 2.993

2.  Cohort profile: the study of health in Pomerania.

Authors:  Henry Völzke; Dietrich Alte; Carsten Oliver Schmidt; Dörte Radke; Roberto Lorbeer; Nele Friedrich; Nicole Aumann; Katharina Lau; Michael Piontek; Gabriele Born; Christoph Havemann; Till Ittermann; Sabine Schipf; Robin Haring; Sebastian E Baumeister; Henri Wallaschofski; Matthias Nauck; Stephanie Frick; Andreas Arnold; Michael Jünger; Julia Mayerle; Matthias Kraft; Markus M Lerch; Marcus Dörr; Thorsten Reffelmann; Klaus Empen; Stephan B Felix; Anne Obst; Beate Koch; Sven Gläser; Ralf Ewert; Ingo Fietze; Thomas Penzel; Martina Dören; Wolfgang Rathmann; Johannes Haerting; Mario Hannemann; Jürgen Röpcke; Ulf Schminke; Clemens Jürgens; Frank Tost; Rainer Rettig; Jan A Kors; Saskia Ungerer; Katrin Hegenscheid; Jens-Peter Kühn; Julia Kühn; Norbert Hosten; Ralf Puls; Jörg Henke; Oliver Gloger; Alexander Teumer; Georg Homuth; Uwe Völker; Christian Schwahn; Birte Holtfreter; Ines Polzer; Thomas Kohlmann; Hans J Grabe; Dieter Rosskopf; Heyo K Kroemer; Thomas Kocher; Reiner Biffar; Ulrich John; Wolfgang Hoffmann
Journal:  Int J Epidemiol       Date:  2010-02-18       Impact factor: 7.196

3.  A pharmacogenetic study of docetaxel and thalidomide in patients with castration-resistant prostate cancer using the DMET genotyping platform.

Authors:  J F Deeken; T Cormier; D K Price; T M Sissung; S M Steinberg; K Tran; D J Liewehr; W L Dahut; X Miao; W D Figg
Journal:  Pharmacogenomics J       Date:  2009-12-29       Impact factor: 3.550

Review 4.  The genetic tyrosinemias.

Authors:  C Ronald Scott
Journal:  Am J Med Genet C Semin Med Genet       Date:  2006-05-15       Impact factor: 3.908

5.  Asymmetrical dimethylarginine predicts progression to dialysis and death in patients with chronic kidney disease: a competing risks modeling approach.

Authors:  Pietro Ravani; Giovanni Tripepi; Fabio Malberti; Sophie Testa; Francesca Mallamaci; Carmine Zoccali
Journal:  J Am Soc Nephrol       Date:  2005-06-08       Impact factor: 10.121

Review 6.  Drug-induced liver injury: past, present and future.

Authors:  Ann K Daly
Journal:  Pharmacogenomics       Date:  2010-05       Impact factor: 2.533

7.  Metabolic footprint of diabetes: a multiplatform metabolomics study in an epidemiological setting.

Authors:  Karsten Suhre; Christa Meisinger; Angela Döring; Elisabeth Altmaier; Petra Belcredi; Christian Gieger; David Chang; Michael V Milburn; Walter E Gall; Klaus M Weinberger; Hans-Werner Mewes; Martin Hrabé de Angelis; H-Erich Wichmann; Florian Kronenberg; Jerzy Adamski; Thomas Illig
Journal:  PLoS One       Date:  2010-11-11       Impact factor: 3.240

Review 8.  Cystinuria.

Authors:  Aditya Mattoo; David S Goldfarb
Journal:  Semin Nephrol       Date:  2008-03       Impact factor: 5.299

9.  Iminoglycinuria and hyperglycinuria are discrete human phenotypes resulting from complex mutations in proline and glycine transporters.

Authors:  Stefan Bröer; Charles G Bailey; Sonja Kowalczuk; Cynthia Ng; Jessica M Vanslambrouck; Helen Rodgers; Christiane Auray-Blais; Juleen A Cavanaugh; Angelika Bröer; John E J Rasko
Journal:  J Clin Invest       Date:  2008-11-06       Impact factor: 14.808

10.  Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum.

Authors:  Christian Gieger; Ludwig Geistlinger; Elisabeth Altmaier; Martin Hrabé de Angelis; Florian Kronenberg; Thomas Meitinger; Hans-Werner Mewes; H-Erich Wichmann; Klaus M Weinberger; Jerzy Adamski; Thomas Illig; Karsten Suhre
Journal:  PLoS Genet       Date:  2008-11-28       Impact factor: 5.917
View more
  104 in total

1.  Diving through the "-omics": the case for deep phenotyping and systems epidemiology.

Authors:  Robin Haring; Henri Wallaschofski
Journal:  OMICS       Date:  2012-02-09

2.  Testing for Ancient Selection Using Cross-population Allele Frequency Differentiation.

Authors:  Fernando Racimo
Journal:  Genetics       Date:  2015-11-23       Impact factor: 4.562

3.  Emerging Biomarkers of Illness Severity: Urinary Metabolites Associated with Sepsis and Necrotizing Methicillin-Resistant Staphylococcus aureus Pneumonia.

Authors:  Lilliam Ambroggio; Todd A Florin; Samir S Shah; Richard Ruddy; Larisa Yeomans; Julie Trexel; Kathleen A Stringer
Journal:  Pharmacotherapy       Date:  2017-07-28       Impact factor: 4.705

4.  Genome-wide association study of NMDA receptor coagonists in human cerebrospinal fluid and plasma.

Authors:  J J Luykx; S C Bakker; W F Visser; N Verhoeven-Duif; J E Buizer-Voskamp; J M den Heijer; M P M Boks; J H Sul; E Eskin; A P Ori; R M Cantor; J Vorstman; E Strengman; J DeYoung; T H Kappen; E Pariama; E P A van Dongen; P Borgdorff; P Bruins; T J de Koning; R S Kahn; R A Ophoff
Journal:  Mol Psychiatry       Date:  2015-02-10       Impact factor: 15.992

5.  Genome-wide association mapping of leaf metabolic profiles for dissecting complex traits in maize.

Authors:  Christian Riedelsheimer; Jan Lisec; Angelika Czedik-Eysenberg; Ronan Sulpice; Anna Flis; Christoph Grieder; Thomas Altmann; Mark Stitt; Lothar Willmitzer; Albrecht E Melchinger
Journal:  Proc Natl Acad Sci U S A       Date:  2012-05-21       Impact factor: 11.205

6.  Inter-individual differences in response to dietary intervention: integrating omics platforms towards personalised dietary recommendations.

Authors:  Johanna W Lampe; Sandi L Navarro; Meredith A J Hullar; Ali Shojaie
Journal:  Proc Nutr Soc       Date:  2013-02-06       Impact factor: 6.297

7.  Rapid Identification of New Biomarkers for the Classification of GM1 Type 2 Gangliosidosis Using an Unbiased 1H NMR-Linked Metabolomics Strategy.

Authors:  Benita C Percival; Yvonne L Latour; Cynthia J Tifft; Martin Grootveld
Journal:  Cells       Date:  2021-03-05       Impact factor: 6.600

8.  Genome-Wide Association Studies of Metabolites in Patients with CKD Identify Multiple Loci and Illuminate Tubular Transport Mechanisms.

Authors:  Yong Li; Peggy Sekula; Matthias Wuttke; Judith Wahrheit; Birgit Hausknecht; Ulla T Schultheiss; Wolfram Gronwald; Pascal Schlosser; Sara Tucci; Arif B Ekici; Ute Spiekerkoetter; Florian Kronenberg; Kai-Uwe Eckardt; Peter J Oefner; Anna Köttgen
Journal:  J Am Soc Nephrol       Date:  2018-03-15       Impact factor: 10.121

9.  A community-driven global reconstruction of human metabolism.

Authors:  Ines Thiele; Neil Swainston; Ronan M T Fleming; Andreas Hoppe; Swagatika Sahoo; Maike K Aurich; Hulda Haraldsdottir; Monica L Mo; Ottar Rolfsson; Miranda D Stobbe; Stefan G Thorleifsson; Rasmus Agren; Christian Bölling; Sergio Bordel; Arvind K Chavali; Paul Dobson; Warwick B Dunn; Lukas Endler; David Hala; Michael Hucka; Duncan Hull; Daniel Jameson; Neema Jamshidi; Jon J Jonsson; Nick Juty; Sarah Keating; Intawat Nookaew; Nicolas Le Novère; Naglis Malys; Alexander Mazein; Jason A Papin; Nathan D Price; Evgeni Selkov; Martin I Sigurdsson; Evangelos Simeonidis; Nikolaus Sonnenschein; Kieran Smallbone; Anatoly Sorokin; Johannes H G M van Beek; Dieter Weichart; Igor Goryanin; Jens Nielsen; Hans V Westerhoff; Douglas B Kell; Pedro Mendes; Bernhard Ø Palsson
Journal:  Nat Biotechnol       Date:  2013-03-03       Impact factor: 54.908

10.  AGXT2 and DDAH-1 genetic variants are highly correlated with serum ADMA and SDMA levels and with incidence of coronary artery disease in Egyptians.

Authors:  Mina Amir; Sally I Hassanein; Mohamed F Abdel Rahman; Mohamed Z Gad
Journal:  Mol Biol Rep       Date:  2018-10-03       Impact factor: 2.316
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.