Literature DB >> 2157063

Alpha interferon suppresses hepatitis B virus enhancer activity and reduces viral gene transcription.

R Tur-Kaspa1, L Teicher, O Laub, A Itin, D Dagan, B R Bloom, D A Shafritz.   

Abstract

Interferons inhibit replication of hepatitis B virus (HBV). The mechanism for this inhibition was investigated by analyzing the effect of interferons on transcription of a chloramphenicol acetyltransferase reporter gene under control of HBV regulatory sequences and by determining the steady-state level of viral mRNAs in permanently HBV-transfected HepG2 cells. Low doses (100 U/ml) of alpha interferon (IFN-alpha) but not IFN-gamma inhibited chloramphenicol acetyltransferase expression in cultured cells transfected with plasmids containing the HBV enhancer linked to either HBV or simian virus 40 promoters. IFN-alpha also lowered expression of HBV mRNA in HBV-transfected HepG2 cells actively replicating virus, suggesting that IFN-alpha inhibits HBV replication by reducing transcription of viral genes driven by the HBV enhancer.

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Year:  1990        PMID： 2157063      PMCID： PMC249322          DOI： 10.1128/JVI.64.4.1821-1824.1990

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  32 in total

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  20 in total

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