Literature DB >> 2498531

Interferon inhibits hepatitis B virus replication in a stable expression system of transfected viral DNA.

Y Hayashi1, K Koike.   

Abstract

The effect of interferon (IFN) on hepatitis B virus (HBV) replication was investigated in a stable expression system, using HepG2 cells transfected with recombinant HBV DNA. IFN was found to cause a marked reduction in the levels of both minus and plus strands of HBV DNA from core particles in the cytoplasm. Neither HBV DNA from virus particles nor the HBV surface antigen in the culture medium primarily underwent change in quantity by treatment with IFN, as was also found for HBV mRNAs and the HBV core antigen/HBV e antigen in the cytoplasm. IFN exerted no influence on HBV DNA synthesis by endogenous DNA polymerase in the core particle fraction. From these findings, it would appear that IFN inhibits HBV replication by blocking some step in the pregenome RNA-primed assembly of core particles.

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Year:  1989        PMID： 2498531      PMCID： PMC250847     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  22 in total

1.  Production of hepatitis B virus by a differentiated human hepatoma cell line after transfection with cloned circular HBV DNA.

Authors:  C Sureau; J L Romet-Lemonne; J I Mullins; M Essex
Journal:  Cell       Date:  1986-10-10       Impact factor: 41.582

2.  Antiviral treatment of chronic hepatitis B virus infection: improvement in liver disease with interferon and adenine arabinoside.

Authors:  G H Scullard; L L Andres; H B Greenberg; J L Smith; V K Sawhney; E A Neal; A S Mahal; H Popper; T C Merigan; W S Robinson; P B Gregory
Journal:  Hepatology       Date:  1981 May-Jun       Impact factor: 17.425

3.  Interferons and cancer: how the promise is being kept.

Authors:  E C Borden
Journal:  Interferon       Date:  1983

4.  Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter.

Authors:  P J Southern; P Berg
Journal:  J Mol Appl Genet       Date:  1982

Review 5.  The importance of having gamma.

Authors:  J Vilcek
Journal:  Interferon       Date:  1982

6.  Recombinant leukocyte interferon treatment of chronic hepatitis B.

Authors:  G Dusheiko; A Dibisceglie; S Bowyer; E Sachs; M Ritchie; B Schoub; M Kew
Journal:  Hepatology       Date:  1985 Jul-Aug       Impact factor: 17.425

7.  A randomized study of the effects of adenine arabinoside 5'-monophosphate (short or long courses) and lymphoblastoid interferon on hepatitis B virus replication.

Authors:  A S Lok; D M Novick; P Karayiannis; A A Dunk; S Sherlock; H C Thomas
Journal:  Hepatology       Date:  1985 Nov-Dec       Impact factor: 17.425

Review 8.  The hepatitis B virus.

Authors:  P Tiollais; C Pourcel; A Dejean
Journal:  Nature       Date:  1985 Oct 10-16       Impact factor: 49.962

9.  Hepatitis B virus particles of plasma and liver contain viral DNA-RNA hybrid molecules.

Authors:  R H Miller; C T Tran; W S Robinson
Journal:  Virology       Date:  1984-11       Impact factor: 3.616

10.  Hepatitis B viral DNA-RNA hybrid molecules in particles from infected liver are converted to viral DNA molecules during an endogenous DNA polymerase reaction.

Authors:  R H Miller; P L Marion; W S Robinson
Journal:  Virology       Date:  1984-11       Impact factor: 3.616
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  22 in total

1.  Lactosamination of liposomes and hepatotropic targeting research.

Authors:  Yong-Peng Chen; Lian Zhang; Qiao-Sheng Lu; Xiao-Rong Feng; Kang-Xian Luo
Journal:  World J Gastroenterol       Date:  2000-08       Impact factor: 5.742

2.  IFN-α inhibits HBV transcription and replication in cell culture and in humanized mice by targeting the epigenetic regulation of the nuclear cccDNA minichromosome.

Authors:  Laura Belloni; Lena Allweiss; Francesca Guerrieri; Natalia Pediconi; Tassilo Volz; Teresa Pollicino; Joerg Petersen; Giovanni Raimondo; Maura Dandri; Massimo Levrero
Journal:  J Clin Invest       Date:  2012-01-17       Impact factor: 14.808

3.  Inhibition of hepatitis B virus replication by APOBEC3G in vitro and in vivo.

Authors:  Yan-Chang Lei; You-Hua Hao; Zheng-Mao Zhang; Yong-Jun Tian; Bao-Ju Wang; Yan Yang; Xi-Ping Zhao; Meng-Ji Lu; Fei-Li Gong; Dong-Liang Yang
Journal:  World J Gastroenterol       Date:  2006-07-28       Impact factor: 5.742

4.  Amplification of full-length hepatitis B virus genomes from samples from patients with low levels of viremia: frequency and functional consequences of PCR-introduced mutations.

Authors:  S Günther; G Sommer; F Von Breunig; A Iwanska; T Kalinina; M Sterneck; H Will
Journal:  J Clin Microbiol       Date:  1998-02       Impact factor: 5.948

5.  Tumor necrosis factor alpha negatively regulates hepatitis B virus gene expression in transgenic mice.

Authors:  P N Gilles; G Fey; F V Chisari
Journal:  J Virol       Date:  1992-06       Impact factor: 5.103

6.  In vitro resistance to interferon of hepatitis B virus with precore mutation.

Authors:  Yan Wang; Lai Wei; Dong Jiang; Xu Cong; Ran Fei; Jiang Xiao; Yu Wang
Journal:  World J Gastroenterol       Date:  2005-02-07       Impact factor: 5.742

7.  Woodchuck gamma interferon upregulates major histocompatibility complex class I transcription but is unable to deplete woodchuck hepatitis virus replication intermediates and RNAs in persistently infected woodchuck primary hepatocytes.

Authors:  Mengji Lu; Beate Lohrengel; Gero Hilken; Thekla Kemper; Michael Roggendorf
Journal:  J Virol       Date:  2002-01       Impact factor: 5.103

8.  Interferons accelerate decay of replication-competent nucleocapsids of hepatitis B virus.

Authors:  Chunxiao Xu; Haitao Guo; Xiao-Ben Pan; Richeng Mao; Wenquan Yu; Xiaodong Xu; Lai Wei; Jinhong Chang; Timothy M Block; Ju-Tao Guo
Journal:  J Virol       Date:  2010-07-07       Impact factor: 5.103

9.  Inhibition of hepatitis B virus replication by the interferon-inducible MxA protein.

Authors:  E Gordien; O Rosmorduc; C Peltekian; F Garreau; C Bréchot; D Kremsdorf
Journal:  J Virol       Date:  2001-03       Impact factor: 5.103

10.  Cytotoxic T lymphocyte activity to hepatitis B virus DNA-transfected HepG2 cells in patients with chronic hepatitis B.

Authors:  Y Ito; S Kakumu; K Yoshioka; T Wakita; T Ishikawa; K Koike
Journal:  Gastroenterol Jpn       Date:  1993-10
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