STUDY OBJECTIVE: To study the effect of intravenous (IV) sedation on blood pressure (BP), heart rate (HR), and respiratory rates (RR) to determine if IV sedatives differ with respect to their effect on BP, HR, and RR. DESIGN: Prospective, randomized, single-blinded, placebo-controlled study. SETTING: Monitored patient care room at a clinical research center. SUBJECTS:60 healthy ASA physical status 1 volunteers. INTERVENTIONS: Subjects were randomized to receive, in increasing doses, one of three IV sedatives: propofol, midazolam, or dexmedetomidine; or saline control. MEASUREMENTS: Blood pressure (systolic, diastolic), HR, and RR were recorded. MAIN RESULTS: A significant dose-dependent BP reduction occurred with dexmedetomidine and, to a lesser degree, with propofol; and there was good agreement of predicted versus measured drug concentrations for all sedatives. Blood pressure and HR of participants who received midazolam did not change. CONCLUSIONS: When administered in sedative doses, dexmedetomidine and, to a lesser extent, midazolam, reduces BP in a dose-dependent fashion. Dexmedetomidine also reduces HR. Midazolam does not affect BP or HR. Published by Elsevier Inc.
RCT Entities:
STUDY OBJECTIVE: To study the effect of intravenous (IV) sedation on blood pressure (BP), heart rate (HR), and respiratory rates (RR) to determine if IV sedatives differ with respect to their effect on BP, HR, and RR. DESIGN: Prospective, randomized, single-blinded, placebo-controlled study. SETTING: Monitored patient care room at a clinical research center. SUBJECTS: 60 healthy ASA physical status 1 volunteers. INTERVENTIONS: Subjects were randomized to receive, in increasing doses, one of three IV sedatives: propofol, midazolam, or dexmedetomidine; or saline control. MEASUREMENTS: Blood pressure (systolic, diastolic), HR, and RR were recorded. MAIN RESULTS: A significant dose-dependent BP reduction occurred with dexmedetomidine and, to a lesser degree, with propofol; and there was good agreement of predicted versus measured drug concentrations for all sedatives. Blood pressure and HR of participants who received midazolam did not change. CONCLUSIONS: When administered in sedative doses, dexmedetomidine and, to a lesser extent, midazolam, reduces BP in a dose-dependent fashion. Dexmedetomidine also reduces HR. Midazolam does not affect BP or HR. Published by Elsevier Inc.
Authors: Lakshmikant Bajpai; Manoj Varshney; Christoph N Seubert; Stanley M Stevens; Jodie V Johnson; Richard A Yost; Donn M Dennis Journal: J Am Soc Mass Spectrom Date: 2005-03-24 Impact factor: 3.109
Authors: Keira P Mason; David Zurakowski; Steven E Zgleszewski; Caroline D Robson; Maureen Carrier; Paul R Hickey; James A Dinardo Journal: Paediatr Anaesth Date: 2008-03-18 Impact factor: 2.556
Authors: Alex Y Bekker; John Basile; Mark Gold; Thomas Riles; Mark Adelman; Germaine Cuff; Jomol P Mathew; Judith D Goldberg Journal: J Neurosurg Anesthesiol Date: 2004-04 Impact factor: 3.956
Authors: G Chaitanya; A Arivazhagan; Sanjib Sinha; K R Madhusudan Reddy; K Thennarasu; R D Bharath; M Bhaskara Rao; B A Chandramouli; P Satishchandra Journal: J Neurosci Rural Pract Date: 2014-11
Authors: Jae Chul Koh; Juyeon Park; Na Young Kim; Ann Hee You; Seo Hee Ko; Dong Woo Han Journal: Medicine (Baltimore) Date: 2017-12 Impact factor: 1.817