Literature DB >> 20810137

Daphnane diterpenoids isolated from Trigonostemon thyrsoideum as HIV-1 antivirals.

Ling Zhang1, Rong-Hua Luo, Fei Wang, Ze-Jun Dong, Liu-Meng Yang, Yong-Tang Zheng, Ji-Kai Liu.   

Abstract

Four highly oxygenated daphnane diterpenoids, trigonothyrins D-G (1-4), were isolated from the stems of Trigonostemon thyrsoideum, and their structures were elucidated on the basis of extensive spectroscopic studies. Inhibitory activity against HIV-1 was assessed for compounds 1, 3 and 4, wherein, 3 showed activity with an EC(50) value of 0.13μg/mL and a therapeutic index (TI) of 75.1.
Copyright © 2010 Elsevier Ltd. All rights reserved.

Entities:  

Mesh：

Substances：

Year:  2010        PMID： 20810137     DOI： 10.1016/j.phytochem.2010.08.008

Source DB:  PubMed          Journal:  Phytochemistry        ISSN： 0031-9422            Impact factor:   4.072


  7 in total

1.  Stelleralides A-C, novel potent anti-HIV daphnane-type diterpenoids from Stellera chamaejasme L.

Authors:  Yoshihisa Asada; Aya Sukemori; Takashi Watanabe; Kuber J Malla; Takafumi Yoshikawa; Wei Li; Kazuo Koike; Chin-Ho Chen; Toshiyuki Akiyama; Keduo Qian; Kyoko Nakagawa-Goto; Susan L Morris-Natschke; Kuo-Hsiung Lee
Journal:  Org Lett       Date:  2011-05-11       Impact factor: 6.005

Review 2.  Structural insights into C1-ligand interactions: Filling the gaps by in silico methods.

Authors:  Sachin Katti; Tatyana I Igumenova
Journal:  Adv Biol Regul       Date:  2021-01-18

3.  Picomolar dichotomous activity of gnidimacrin against HIV-1.

Authors:  Li Huang; Phong Ho; Jie Yu; Lei Zhu; Kuo-Hsiung Lee; Chin-Ho Chen
Journal:  PLoS One       Date:  2011-10-24       Impact factor: 3.240

4.  Potent and Selective Activity against Human Immunodeficiency Virus 1 (HIV-1) of Thymelaea hirsuta Extracts.

Authors:  Giuseppina Sanna; Silvia Madeddu; Giuseppe Murgia; Gabriele Serreli; Michela Begala; Pierluigi Caboni; Alessandra Incani; Gianluigi Franci; Marilena Galdiero; Gabriele Giliberti
Journal:  Viruses       Date:  2020-06-19       Impact factor: 5.048

5.  Daphnane-Type Diterpenes from Stelleropsis tianschanica and Their Antitumor Activity.

Authors:  Xiaoyan He; Xiatiguli Abulizi; Xiaowan Li; Guoxu Ma; Zhaocui Sun; Hongyan Wei; Xudong Xu; Leiling Shi; Jing Zhang
Journal:  Molecules       Date:  2022-09-04       Impact factor: 4.927

Review 6.  Current Strategies for Inhibition of Chikungunya Infection.

Authors:  Bharat Bhusan Subudhi; Soma Chattopadhyay; Priyadarsee Mishra; Abhishek Kumar
Journal:  Viruses       Date:  2018-05-03       Impact factor: 5.048

7.  Epigenetic modification in histone deacetylase deletion strain of Calcarisporium arbuscula leads to diverse diterpenoids.

Authors:  Jian Bai; Rong Mu; Man Dou; Daojiang Yan; Bingyu Liu; Qian Wei; Jun Wan; Yi Tang; Youcai Hu
Journal:  Acta Pharm Sin B       Date:  2018-02-21       Impact factor: 11.413
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.