Literature DB >> 32997496

Isolation, Structural Elucidation, and Anti-HIV Activity of Daphnane Diterpenoids from Daphne odora.

Kouharu Otsuki1, Wei Li1, Kasumi Miura1, Yoshihisa Asada1, Li Huang2, Chin-Ho Chen2, Kuo-Hsiung Lee3,4, Kazuo Koike1.   

Abstract

Five new [daphneodorins D-H (1, 5, and 10-12)] and seven known daphnane diterpenoids (2-4 and 6-9) were isolated from Daphne odora. The structures of the new compounds were elucidated by extensive physicochemical and spectroscopic analysis. The isolated compounds were evaluated for their anti-HIV activity against HIV-1 infection of MT4 cells. Nine daphnane diterpenoid orthoesters (1-9) showed potent anti-HIV activity with EC50 values of 1.5-7.7 nM.

Entities:  

Year:  2020        PMID： 32997496      PMCID： PMC8176625          DOI： 10.1021/acs.jnatprod.0c00540

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  13 in total

1.  Letter: Gnididin, gniditrin, and gnidicin, novel potent antileukemic diterpenoid esters from Gnidia lamprantha.

Authors:  S M Kupchan; J G Sweeney; R L Baxter; T Murae; V A Zimmerly; B R Sickles
Journal:  J Am Chem Soc       Date:  1975-02-05       Impact factor: 15.419

Review 2.  Plant orthoesters.

Authors:  Shang-Gao Liao; Hua-Dong Chen; Jian-Min Yue
Journal:  Chem Rev       Date:  2009-03-11       Impact factor: 60.622

3.  Novel diterpenoids with potent inhibitory activity against endothelium cell HMEC and cytotoxic activities from a well-known TCM plant Daphne genkwa.

Authors:  Zha-Jun Zhan; Cheng-Qi Fan; Jian Ding; Jian-Min Yue
Journal:  Bioorg Med Chem       Date:  2005-02-01       Impact factor: 3.641

4.  Daphnane-type diterpene esters with cytotoxic and anti-HIV-1 activities from Daphne acutiloba Rehd.

Authors:  Sheng Zhuo Huang; Xing Jie Zhang; Xing Yao Li; Ling Mei Kong; He Zhong Jiang; Qing Yun Ma; Yu Qing Liu; Jiang Miao Hu; Yong Tang Zheng; Yan Li; Jun Zhou; You Xing Zhao
Journal:  Phytochemistry       Date:  2011-12-21       Impact factor: 4.072

5.  Daphneodorins A-C, Anti-HIV Gnidimacrin Related Macrocyclic Daphnane Orthoesters from Daphne odora.

Authors:  Kouharu Otsuki; Wei Li; Yoshihisa Asada; Chin-Ho Chen; Kuo-Hsiung Lee; Kazuo Koike
Journal:  Org Lett       Date:  2019-11-04       Impact factor: 6.005

6.  Minor daphnane-type diterpenoids from Wikstroemia retusa.

Authors:  F Abe; Y Iwase; T Yamauchi; K Kinjo; S Yaga; M Ishii; M Iwahana
Journal:  Phytochemistry       Date:  1998-03       Impact factor: 4.072

7.  Isolation, structure determination, and anti-HIV evaluation of tigliane-type diterpenes and biflavonoid from Stellera chamaejasme.

Authors:  Yoshihisa Asada; Aya Sukemori; Takashi Watanabe; Kuber J Malla; Takafumi Yoshikawa; Wei Li; Xinzhu Kuang; Kazuo Koike; Chin-Ho Chen; Toshiyuki Akiyama; Keduo Qian; Kyoko Nakagawa-Goto; Susan L Morris-Natschke; Yan Lu; Kuo-Hsiung Lee
Journal:  J Nat Prod       Date:  2013-04-23       Impact factor: 4.050

8.  Preparation of yuanhuacine and relative daphne diterpene esters from Daphne genkwa and structure-activity relationship of potent inhibitory activity against DNA topoisomerase I.

Authors:  Shixuan Zhang; Xiaona Li; Fenghong Zhang; Puwen Yang; Xiujuan Gao; Qiling Song
Journal:  Bioorg Med Chem       Date:  2006-02-20       Impact factor: 3.641

9.  Daphnane-type diterpenes with inhibitory activities against human cancer cell lines from Daphne genkwa.

Authors:  Feifei Li; Qian Sun; Lili Hong; Lingzhi Li; Yingying Wu; Mingyu Xia; Takshi Ikejima; Ying Peng; Shaojiang Song
Journal:  Bioorg Med Chem Lett       Date:  2013-03-15       Impact factor: 2.823

10.  Trigoxyphins H and I: two new daphnane diterpenoids from Trigonostemon xyphophylloides.

Authors:  Biao Yang; Guang-Ying Chen; Xiao-Ping Song; Liu-Qing Yang; Chang-Ri Han; Xiang-Yang Wu; Xiao-Man Li; Bing-Yan Zou
Journal:  Bioorg Med Chem Lett       Date:  2012-03-24       Impact factor: 2.823
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  3 in total

Review 1.  Phytochemistry and Pharmacological Activities of the Diterpenoids from the Genus Daphne.

Authors:  Yi-Wen Nie; Yuan Li; Lan Luo; Chun-Yan Zhang; Wei Fan; Wei-Ying Gu; Kou-Rong Shi; Xiao-Xiang Zhai; Jian-Yong Zhu
Journal:  Molecules       Date:  2021-10-31       Impact factor: 4.411

2.  HPLC-Based Purification and Isolation of Potent Anti-HIV and Latency Reversing Daphnane Diterpenes from the Medicinal Plant Gnidia sericocephala (Thymelaeaceae).

Authors:  Babalwa Tembeni; Amanda Sciorillo; Luke Invernizzi; Thomas Klimkait; Lorena Urda; Phanankosi Moyo; Dashnie Naidoo-Maharaj; Nathan Levitties; Kwasi Gyampoh; Guorui Zu; Zhe Yuan; Karam Mounzer; Siphathimandla Nkabinde; Magugu Nkabinde; Nceba Gqaleni; Ian Tietjen; Luis J Montaner; Vinesh Maharaj
Journal:  Viruses       Date:  2022-06-30       Impact factor: 5.818

3.  Daphnane-Type Diterpenes from Stelleropsis tianschanica and Their Antitumor Activity.

Authors:  Xiaoyan He; Xiatiguli Abulizi; Xiaowan Li; Guoxu Ma; Zhaocui Sun; Hongyan Wei; Xudong Xu; Leiling Shi; Jing Zhang
Journal:  Molecules       Date:  2022-09-04       Impact factor: 4.927
  3 in total

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