Literature DB >> 23345919

A computer-glimpse of the origin of life.

Christoph Kuhn1.   

Abstract

Evolution is assumed to begin in a very particular compartmentalized location with periodic conditions. A highly diversified world is the driving force for the continuous increase in complexity by colonizing increasingly less favourable regions. Modeling the "origin-of-life" a Darwinian cyclic process is simulated (multiplication with sporadic errors followed by a construction and selection).Starting from a RNA-world (R-strands of R(1) and R(2) monomers building Hairpin-Assembler devices) and introducing another kind of monomers (A(1) and A(2) which interlink to the Hairpin-Assembler devices such that they become bound and form an A-oligomer) it is shown that a simple translation apparatus evolves producing enzymes (specific sequences of A(1) and A(2) monomers given by the sequences of R(1) and R(2) monomers on the assembler-strands). Later on D-strands are introduced, which are not capable of participating in the synthesis of A-oligomers. These D-strands become carriers of the genetic information and induce the formation of increasingly complex entities of functionally interplaying components.

Keywords:  DNA-RNA-protein world; RNA world; RNA-protein world; assembler; assembler-hairpin-enzyme device; computer simulation; emergence and storage of information; evolution; fundamental conditions; genetic apparatus; genetic code; hairpin; origin of life; self organisation

Year:  2005        PMID: 23345919      PMCID: PMC3456338          DOI: 10.1007/s10867-005-6163-4

Source DB:  PubMed          Journal:  J Biol Phys        ISSN: 0092-0606            Impact factor:   1.365


  2 in total

1.  Computer-modeling origin of a simple genetic apparatus.

Authors:  C Kuhn
Journal:  Proc Natl Acad Sci U S A       Date:  2001-07-17       Impact factor: 11.205

Review 2.  Diversified world: drive to life's origin?!

Authors:  Hans Kuhn; Christoph Kuhn
Journal:  Angew Chem Int Ed Engl       Date:  2003-01-20       Impact factor: 15.336

  2 in total
  2 in total

1.  An information-carrying and knowledge-producing molecular machine. A Monte-Carlo simulation.

Authors:  Christoph Kuhn
Journal:  J Mol Model       Date:  2011-05-11       Impact factor: 1.810

2.  Immune response to a variable pathogen: a stochastic model with two interlocked Darwinian entities.

Authors:  Christoph Kuhn
Journal:  Comput Math Methods Med       Date:  2012-12-02       Impact factor: 2.238

  2 in total

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