Literature DB >> 21546546

New experiments for an undivided genetics.

Michael R Rose1, Laurence D Mueller, Molly K Burke.   

Abstract

There used to be a broad split within the experimental genetics research community between those who did mechanistic research using homozygous laboratory strains and those who studied patterns of genetic variation in wild populations. The former benefited from the advantage of reproducible experiments, but faced difficulties of interpretation given possible genomic and evolutionary complexities. The latter research approach featured readily interpreted evolutionary and genomic contexts, particularly phylogeny, but was poor at determining functional significance. Such burgeoning experimental strategies as genome-wide analysis of quantitative trait loci, genotype-phenotype associations, and the products of experimental evolution are now fostering a unification of experimental genetic research that strengthens its scientific power.

Mesh:

Year:  2011        PMID: 21546546      PMCID: PMC3120144          DOI: 10.1534/genetics.111.128900

Source DB:  PubMed          Journal:  Genetics        ISSN: 0016-6731            Impact factor:   4.562


  40 in total

1.  Quantitative trait loci with age-specific effects on fecundity in Drosophila melanogaster.

Authors:  Jeff Leips; Paul Gilligan; Trudy F C Mackay
Journal:  Genetics       Date:  2005-11-04       Impact factor: 4.562

2.  Adaptionism-30 years after Gould and Lewontin.

Authors:  Rasmus Nielsen
Journal:  Evolution       Date:  2009-07-30       Impact factor: 3.694

3.  Approximate Bayesian inference reveals evidence for a recent, severe bottleneck in a Netherlands population of Drosophila melanogaster.

Authors:  Kevin Thornton; Peter Andolfatto
Journal:  Genetics       Date:  2005-11-19       Impact factor: 4.562

4.  Genotype-environment interaction for quantitative trait loci affecting life span in Drosophila melanogaster.

Authors:  C Vieira; E G Pasyukova; Z B Zeng; J B Hackett; R F Lyman; T F Mackay
Journal:  Genetics       Date:  2000-01       Impact factor: 4.562

5.  Common SNPs explain a large proportion of the heritability for human height.

Authors:  Jian Yang; Beben Benyamin; Brian P McEvoy; Scott Gordon; Anjali K Henders; Dale R Nyholt; Pamela A Madden; Andrew C Heath; Nicholas G Martin; Grant W Montgomery; Michael E Goddard; Peter M Visscher
Journal:  Nat Genet       Date:  2010-06-20       Impact factor: 38.330

6.  Genome-wide analysis of a long-term evolution experiment with Drosophila.

Authors:  Molly K Burke; Joseph P Dunham; Parvin Shahrestani; Kevin R Thornton; Michael R Rose; Anthony D Long
Journal:  Nature       Date:  2010-09-15       Impact factor: 49.962

7.  Classic selective sweeps were rare in recent human evolution.

Authors:  Ryan D Hernandez; Joanna L Kelley; Eyal Elyashiv; S Cord Melton; Adam Auton; Gilean McVean; Guy Sella; Molly Przeworski
Journal:  Science       Date:  2011-02-18       Impact factor: 47.728

8.  Adaptive evolution of non-coding DNA in Drosophila.

Authors:  Peter Andolfatto
Journal:  Nature       Date:  2005-10-20       Impact factor: 49.962

Review 9.  Finding the missing heritability of complex diseases.

Authors:  Teri A Manolio; Francis S Collins; Nancy J Cox; David B Goldstein; Lucia A Hindorff; David J Hunter; Mark I McCarthy; Erin M Ramos; Lon R Cardon; Aravinda Chakravarti; Judy H Cho; Alan E Guttmacher; Augustine Kong; Leonid Kruglyak; Elaine Mardis; Charles N Rotimi; Montgomery Slatkin; David Valle; Alice S Whittemore; Michael Boehnke; Andrew G Clark; Evan E Eichler; Greg Gibson; Jonathan L Haines; Trudy F C Mackay; Steven A McCarroll; Peter M Visscher
Journal:  Nature       Date:  2009-10-08       Impact factor: 49.962

10.  Selection at linked sites shapes heritable phenotypic variation in C. elegans.

Authors:  Matthew V Rockman; Sonja S Skrovanek; Leonid Kruglyak
Journal:  Science       Date:  2010-10-15       Impact factor: 47.728

View more
  7 in total

Review 1.  The future of model organisms in human disease research.

Authors:  Timothy J Aitman; Charles Boone; Gary A Churchill; Michael O Hengartner; Trudy F C Mackay; Derek L Stemple
Journal:  Nat Rev Genet       Date:  2011-07-18       Impact factor: 53.242

2.  Adaptation of Drosophila to a novel laboratory environment reveals temporally heterogeneous trajectories of selected alleles.

Authors:  Pablo Orozco-terWengel; Martin Kapun; Viola Nolte; Robert Kofler; Thomas Flatt; Christian Schlötterer
Journal:  Mol Ecol       Date:  2012-06-21       Impact factor: 6.622

3.  Hsp90 is important for fecundity, longevity, and buffering of cryptic deleterious variation in wild fly populations.

Authors:  Bing Chen; Andreas Wagner
Journal:  BMC Evol Biol       Date:  2012-02-27       Impact factor: 3.260

4.  Exploring the Phenotypic Space and the Evolutionary History of a Natural Mutation in Drosophila melanogaster.

Authors:  Anna Ullastres; Natalia Petit; Josefa González
Journal:  Mol Biol Evol       Date:  2015-04-09       Impact factor: 16.240

Review 5.  Life-History Evolution and the Genetics of Fitness Components in Drosophila melanogaster.

Authors:  Thomas Flatt
Journal:  Genetics       Date:  2020-01       Impact factor: 4.562

6.  What is Aging?

Authors:  Michael R Rose; Thomas Flatt; Joseph L Graves; Lee F Greer; Daniel E Martinez; Margarida Matos; Laurence D Mueller; Robert J Shmookler Reis; Parvin Shahrestani
Journal:  Front Genet       Date:  2012-07-20       Impact factor: 4.599

7.  A guide for the design of evolve and resequencing studies.

Authors:  Robert Kofler; Christian Schlötterer
Journal:  Mol Biol Evol       Date:  2013-11-09       Impact factor: 16.240

  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.