Literature DB >> 21546286

Ancestry of African Americans with sickle cell disease.

Nadia Solovieff1, Stephen W Hartley, Clinton T Baldwin, Elizabeth S Klings, Mark T Gladwin, James G Taylor, Gregory J Kato, Lindsay A Farrer, Martin H Steinberg, Paola Sebastiani.   

Abstract

The inheritance of genetic disease depends on ancestry that must be considered when interpreting genetic association studies and can provide insights when comparing traits in a population. We compared the genetic profiles of African Americans with sickle cell disease to those of Black Africans and Caucasian populations of European descent and found that they are less genetically admixed than other African Americans and have an ancestry similar to Yorubans, Mandenkas and Bantu.
Copyright © 2011 Elsevier Inc. All rights reserved.

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Year:  2011        PMID: 21546286      PMCID: PMC3116635          DOI: 10.1016/j.bcmd.2011.04.002

Source DB:  PubMed          Journal:  Blood Cells Mol Dis        ISSN: 1079-9796            Impact factor:   3.039


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