Literature DB >> 14685227

The International HapMap Project.

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Abstract

The goal of the International HapMap Project is to determine the common patterns of DNA sequence variation in the human genome and to make this information freely available in the public domain. An international consortium is developing a map of these patterns across the genome by determining the genotypes of one million or more sequence variants, their frequencies and the degree of association between them, in DNA samples from populations with ancestry from parts of Africa, Asia and Europe. The HapMap will allow the discovery of sequence variants that affect common disease, will facilitate development of diagnostic tools, and will enhance our ability to choose targets for therapeutic intervention.

Entities:  

Keywords:  Biomedical and Behavioral Research; Empirical Approach; Genetics and Reproduction

Mesh:

Substances:

Year:  2003        PMID: 14685227     DOI: 10.1038/nature02168

Source DB:  PubMed          Journal:  Nature        ISSN: 0028-0836            Impact factor:   49.962


  2000 in total

1.  GLCCI1 single nucleotide polymorphisms in pediatric nephrotic syndrome.

Authors:  Hae Il Cheong; Hee Gyung Kang; Johannes Schlondorff
Journal:  Pediatr Nephrol       Date:  2012-06-04       Impact factor: 3.714

2.  Genetic polymorphisms in MicroRNA-related genes as predictors of clinical outcomes in colorectal adenocarcinoma patients.

Authors:  Moubin Lin; Jian Gu; Cathy Eng; Lee M Ellis; Michelle A Hildebrandt; Jie Lin; Maosheng Huang; George A Calin; Dingzhi Wang; Raymond N Dubois; Ernest T Hawk; Xifeng Wu
Journal:  Clin Cancer Res       Date:  2012-06-01       Impact factor: 12.531

3.  SIRT1 activates MAO-A in the brain to mediate anxiety and exploratory drive.

Authors:  Sergiy Libert; Kelli Pointer; Eric L Bell; Abhirup Das; Dena E Cohen; John M Asara; Karen Kapur; Sven Bergmann; Martin Preisig; Takeshi Otowa; Kenneth S Kendler; Xiangning Chen; John M Hettema; Edwin J van den Oord; Justin P Rubio; Leonard Guarente
Journal:  Cell       Date:  2011-12-08       Impact factor: 41.582

Review 4.  Understanding the genetics of coronary artery disease through the lens of noninvasive imaging.

Authors:  Eunice Yang; Jose D Vargas; David A Bluemke
Journal:  Expert Rev Cardiovasc Ther       Date:  2012-01

Review 5.  Induced pluripotent stem cells: the new patient?

Authors:  Milena Bellin; Maria C Marchetto; Fred H Gage; Christine L Mummery
Journal:  Nat Rev Mol Cell Biol       Date:  2012-10-04       Impact factor: 94.444

Review 6.  Update on perilipin polymorphisms and obesity.

Authors:  Caren E Smith; José M Ordovás
Journal:  Nutr Rev       Date:  2012-10       Impact factor: 7.110

7.  Pharmacogenomic Variability of Oral Baclofen Clearance and Clinical Response in Children With Cerebral Palsy.

Authors:  Matthew J McLaughlin; Yang He; Janice Brunstrom-Hernandez; Liu Lin Thio; Bruce C Carleton; Colin J D Ross; Andrea Gaedigk; Andrew Lewandowski; Hongying Dai; William J Jusko; J Steven Leeder
Journal:  PM R       Date:  2017-09-01       Impact factor: 2.298

8.  Common genetic variation in sFRP5 is associated with fat distribution in men.

Authors:  J K Van Camp; S Beckers; D Zegers; A Verrijken; L F Van Gaal; W Van Hul
Journal:  Endocrine       Date:  2013-11-28       Impact factor: 3.633

9.  Identification of a polymorphism in the RING finger of human Bmi-1 that causes its degradation by the ubiquitin-proteasome system.

Authors:  Jie Zhang; Kevin D Sarge
Journal:  FEBS Lett       Date:  2009-02-20       Impact factor: 4.124

10.  Genetic epistasis of IL23/IL17 pathway genes in Crohn's disease.

Authors:  Dermot P B McGovern; Jerome I Rotter; Ling Mei; Talin Haritunians; Carol Landers; Carrie Derkowski; Deb Dutridge; Marla Dubinsky; Andy Ippoliti; Eric Vasiliauskas; Emebet Mengesha; Lily King; Sheila Pressman; Stephan R Targan; Kent D Taylor
Journal:  Inflamm Bowel Dis       Date:  2009-06       Impact factor: 5.325

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