J Liao1, N Saito, A Ozonoff, H Jara, M Steinberg, O Sakai. 1. Department of Radiology, Boston Medical Center, Boston University School of Medicine, Joseph Liao, 86 Saint Botolph St, #13, Boston, MA 02116, USA. joseph.h.liao@gmail.com
Abstract
OBJECTIVES: The purpose of this prospective study was to characterize the MR relaxometric features of the major salivary glands in patients with sickle cell disease (SCD). METHODS: 15 patients with SCD (aged 19.8-43.6 years) and 12 controls were imaged with the mixed turbo-spin echo pulse sequence. The major salivary glands were manually segmented and T1, T2 and secular T2 relaxometry histograms were modelled with Gaussian functions. RESULTS: Shortened T1 relaxation times were seen solely in the submandibular glands of patients with SCD (747.5±54.8 ms vs 807.1±38.3 ms, p<0.001). Slight T2 and secular T2 shortening were seen in the parotid gland; however, this difference was not significant (p=0.07). The sublingual gland showed no changes under MR relaxometry. There was no difference in glandular volumes, and no correlation was demonstrated between history of blood transfusion and salivary gland relaxometry. CONCLUSIONS: Patients with SCD exhibited changes in quantitative MRI T1 relaxometry histograms of the submandibular glands.
OBJECTIVES: The purpose of this prospective study was to characterize the MR relaxometric features of the major salivary glands in patients with sickle cell disease (SCD). METHODS: 15 patients with SCD (aged 19.8-43.6 years) and 12 controls were imaged with the mixed turbo-spin echo pulse sequence. The major salivary glands were manually segmented and T1, T2 and secular T2 relaxometry histograms were modelled with Gaussian functions. RESULTS: Shortened T1 relaxation times were seen solely in the submandibular glands of patients with SCD (747.5±54.8 ms vs 807.1±38.3 ms, p<0.001). Slight T2 and secular T2 shortening were seen in the parotid gland; however, this difference was not significant (p=0.07). The sublingual gland showed no changes under MR relaxometry. There was no difference in glandular volumes, and no correlation was demonstrated between history of blood transfusion and salivary gland relaxometry. CONCLUSIONS:Patients with SCD exhibited changes in quantitative MRI T1 relaxometry histograms of the submandibular glands.
Authors: N Saito; M Watanabe; J Liao; E N Flower; R N Nadgir; M H Steinberg; O Sakai Journal: AJNR Am J Neuroradiol Date: 2011-09-29 Impact factor: 3.825
Authors: Nadia Solovieff; Stephen W Hartley; Clinton T Baldwin; Elizabeth S Klings; Mark T Gladwin; James G Taylor; Gregory J Kato; Lindsay A Farrer; Martin H Steinberg; Paola Sebastiani Journal: Blood Cells Mol Dis Date: 2011-05-04 Impact factor: 3.039
Authors: Julie Makani; Sharon E Cox; Deogratius Soka; Albert N Komba; Julie Oruo; Hadija Mwamtemi; Pius Magesa; Stella Rwezaula; Elineema Meda; Josephine Mgaya; Brett Lowe; David Muturi; David J Roberts; Thomas N Williams; Kisali Pallangyo; Jesse Kitundu; Gregory Fegan; Fenella J Kirkham; Kevin Marsh; Charles R Newton Journal: PLoS One Date: 2011-02-16 Impact factor: 3.240