Literature DB >> 2154603

BK virus T antigens induce kidney carcinomas and thymoproliferative disorders in transgenic mice.

S A Dalrymple1, K L Beemon.   

Abstract

Renal adenocarcinomas and/or extremely enlarged thymuses (up to 250 times normal size) were observed in 60 of 78 mice in a transgenic line containing a single copy of the BK virus (BKV) early region. Enlarged thymuses from different mice displayed thymoproliferative disorders of varying severity, ranging from extreme hyperplasia to thymomas and lymphomas. All kidney tumor DNAs analyzed contained highly amplified BKV sequences with multiple rearrangements in cellular DNA flanking the transgene, whereas amplification and rearrangement were observed only in some enlarged thymus DNAs. Expression of BKV T antigens was restricted to epithelial cells of kidney tumors and enlarged thymuses and was not detected in any normal tissues. Although thymocytes proliferated to numbers much greater than normal in the enlarged thymuses, no T antigen expression was detected in thymocytes.

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Year:  1990        PMID： 2154603      PMCID： PMC249232          DOI： 10.1128/JVI.64.3.1182-1191.1990

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  24 in total

1.  Decreasing the number of 68-base-pair tandem repeats in the BK virus transcriptional control region reduces plaque size and enhances transforming capacity.

Authors:  S Watanabe; K Yoshiike
Journal:  J Virol       Date:  1985-09       Impact factor: 5.103

2.  Elastase I promoter directs expression of human growth hormone and SV40 T antigen genes to pancreatic acinar cells in transgenic mice.

Authors:  D M Ornitz; R D Palmiter; A Messing; R E Hammer; C A Pinkert; R L Brinster
Journal:  Cold Spring Harb Symp Quant Biol       Date:  1985

3.  Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter.

Authors:  D A Melton; P A Krieg; M R Rebagliati; T Maniatis; K Zinn; M R Green
Journal:  Nucleic Acids Res       Date:  1984-09-25       Impact factor: 16.971

4.  A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity.

Authors:  A P Feinberg; B Vogelstein
Journal:  Anal Biochem       Date:  1983-07-01       Impact factor: 3.365

Review 5.  The molecular genetics of cellular oncogenes.

Authors:  H E Varmus
Journal:  Annu Rev Genet       Date:  1984       Impact factor: 16.830

6.  Oncogenesis of the lens in transgenic mice.

Authors:  K A Mahon; A B Chepelinsky; J S Khillan; P A Overbeek; J Piatigorsky; H Westphal
Journal:  Science       Date:  1987-03-27       Impact factor: 47.728

7.  Transformation of primary human embryonic kidney cells to anchorage independence by a combination of BK virus DNA and the Harvey-ras oncogene.

Authors:  A Pater; M M Pater
Journal:  J Virol       Date:  1986-05       Impact factor: 5.103

8.  Human polyomavirus JC virus genome.

Authors:  R J Frisque; G L Bream; M T Cannella
Journal:  J Virol       Date:  1984-08       Impact factor: 5.103

Review 9.  BK viral enhancer element and a human cellular homolog.

Authors:  N Rosenthal; M Kress; P Gruss; G Khoury
Journal:  Science       Date:  1983-11-18       Impact factor: 47.728

10.  Early regions of JC virus and BK virus induce distinct and tissue-specific tumors in transgenic mice.

Authors:  J A Small; G Khoury; G Jay; P M Howley; G A Scangos
Journal:  Proc Natl Acad Sci U S A       Date:  1986-11       Impact factor: 11.205
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  18 in total

1.  Simian virus 40 infection of humans.

Authors:  Robert L Garcea; Michael J Imperiale
Journal:  J Virol       Date:  2003-05       Impact factor: 5.103

2.  Recurring theme of changes in the transcriptional control region of BK virus during adaptation to cell culture.

Authors:  R Rubinstein; B C Schoonakker; E H Harley
Journal:  J Virol       Date:  1991-03       Impact factor: 5.103

3.  Novel mechanisms of E2F induction by BK virus large-T antigen: requirement of both the pRb-binding and the J domains.

Authors:  K F Harris; J B Christensen; E H Radany; M J Imperiale
Journal:  Mol Cell Biol       Date:  1998-03       Impact factor: 4.272

4.  A screen for modulators of large T antigen's ATPase activity uncovers novel inhibitors of Simian Virus 40 and BK virus replication.

Authors:  Sandlin P Seguin; Alex W Ireland; Tushar Gupta; Christine M Wright; Yoshinari Miyata; Peter Wipf; James M Pipas; Jason E Gestwicki; Jeffrey L Brodsky
Journal:  Antiviral Res       Date:  2012-08-07       Impact factor: 5.970

5.  Morphological, histochemical, immunohistochemical, and ultrastructural characterization of tumors and dysplastic and non-neoplastic lesions arising in BK virus/tat transgenic mice.

Authors:  G Altavilla; C Trabanelli; M Merlin; A Caputo; M Lanfredi; G Barbanti-Brodano; A Corallini
Journal:  Am J Pathol       Date:  1999-04       Impact factor: 4.307

6.  Restriction of human polyomavirus BK virus DNA replication in murine cells and extracts.

Authors:  Cathal Mahon; Bo Liang; Irina Tikhanovich; Johanna R Abend; Michael J Imperiale; Heinz P Nasheuer; William R Folk
Journal:  J Virol       Date:  2009-03-18       Impact factor: 5.103

7.  BK virus large T antigen: interactions with the retinoblastoma family of tumor suppressor proteins and effects on cellular growth control.

Authors:  K F Harris; J B Christensen; M J Imperiale
Journal:  J Virol       Date:  1996-04       Impact factor: 5.103

8.  Global effects of BKV infection on gene expression in human primary kidney epithelial cells.

Authors:  Johanna R Abend; Jonathan A Low; Michael J Imperiale
Journal:  Virology       Date:  2009-11-28       Impact factor: 3.616

9.  BK virus as a cofactor in the etiology of prostate cancer in its early stages.

Authors:  Dweepanita Das; Kirk Wojno; Michael J Imperiale
Journal:  J Virol       Date:  2007-12-26       Impact factor: 5.103

10.  A viral long terminal repeat expressed in CD4+CD8+ precursors is downregulated in mature peripheral CD4-CD8+ or CD4+CD8- T cells.

Authors:  Y Paquette; L Doyon; A Laperrière; Z Hanna; J Ball; R P Sekaly; P Jolicoeur
Journal:  Mol Cell Biol       Date:  1992-08       Impact factor: 4.272
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