Literature DB >> 21532873

Feng Chen's work on translational and clinical imaging.

Feng Chen1.   

Abstract

Dr. Feng Chen is a chief medical doctor and the vice chairman of the Department of Radiology in Zhong Da Hospital at Southeast University, Nanjing, China and a senior researcher in the Department of Radiology at the Catholic University of Leuven, Belgium. His main areas of interest are translational imaging research including stroke, tumor angiogenesis, assessment of therapeutic response in solid tumors, and magnetic resonance contrast media. Dr. Feng Chen has published 44 scientific papers in peer-reviewed international journals. He and his colleagues have developed an imaging platform which includes animal models, animal preparations and multiparametric magnetic resonance imaging (MRI) protocols for translational animal imaging research using clinical machines. His MRI findings on rodent stroke are considered to "serve as a model for future laboratory investigations of treatment of acute stroke and unify the approaches developed for clinical studies". He and his colleagues have introduced a novel liver tumor model in rodents, in which a series of studies concerning the antitumor activity of vascular disrupting agents have been successively conducted and assessed by in vivo MRI, especially by diffusion weighted imaging as an imaging biomarker. His goal is to provide valuable references for clinical practice and to contribute to the translation of animal imaging research into patient applications.

Entities:  

Keywords:  Animal study; Contrast agent; Magnetic resonance imaging; Therapeutic assessment; Translational research; Tumor angiogenesis; Tumor therapy; Vascular disrupting agent

Year:  2011        PMID: 21532873      PMCID: PMC3084436          DOI: 10.4329/wjr.v3.i4.120

Source DB:  PubMed          Journal:  World J Radiol        ISSN: 1949-8470


  32 in total

1.  Hepatic lesion detection after superparamagnetic iron oxide enhancement: comparison of five T2-weighted sequences at 1.0 T by using alternative-free response receiver operating characteristic analysis.

Authors:  J Ward; F Chen; J A Guthrie; D Wilson; J P Lodge; J I Wyatt; P J Robinson
Journal:  Radiology       Date:  2000-01       Impact factor: 11.105

2.  Spiral CT in gastric carcinoma: comparison with barium study, fiberoptic gastroscopy and histopathology.

Authors:  Feng Chen; Yi-Cheng Ni; Kai-Er Zheng; Sheng-Hong Ju; Jun Sun; Xi-Long Ou; Man-Hua Xu; Hao Zhang; Guy Marchal
Journal:  World J Gastroenterol       Date:  2003-07       Impact factor: 5.742

Review 3.  Disrupting tumour blood vessels.

Authors:  Gillian M Tozer; Chryso Kanthou; Bruce C Baguley
Journal:  Nat Rev Cancer       Date:  2005-06       Impact factor: 60.716

4.  Diffusion-weighted MR imaging in monitoring the effect of a vascular targeting agent on rhabdomyosarcoma in rats.

Authors:  Harriet C Thoeny; Frederik De Keyzer; Feng Chen; Yicheng Ni; Willy Landuyt; Eric K Verbeken; Hilde Bosmans; Guy Marchal; Robert Hermans
Journal:  Radiology       Date:  2005-03       Impact factor: 11.105

5.  MR imaging of the liver and spleen: a comparison of the effects on signal intensity of two superparamagnetic iron oxide agents.

Authors:  F Chen; J Ward; P J Robinson
Journal:  Magn Reson Imaging       Date:  1999-05       Impact factor: 2.546

6.  Dynamic susceptibility contrast-enhanced perfusion MR imaging at 1.5 T predicts final infarct size in a rat stroke model.

Authors:  Feng Chen; Yasuhiro Suzuki; Nobuo Nagai; Ronald Peeters; Guy Marchal; Yicheng Ni
Journal:  J Neurosci Methods       Date:  2005-01-30       Impact factor: 2.390

7.  Visualization of stroke with clinical MR imagers in rats: a feasibility study.

Authors:  Feng Chen; Yasuhiro Suzuki; Nobuo Nagai; Ronald Peeters; Kenneth Coenegrachts; Walter Coudyzer; Guy Marchal; Yicheng Ni
Journal:  Radiology       Date:  2004-10-21       Impact factor: 11.105

Review 8.  Necrosis avid contrast agents: functional similarity versus structural diversity.

Authors:  Yicheng Ni; Guy Bormans; Feng Chen; Alfons Verbruggen; Guy Marchal
Journal:  Invest Radiol       Date:  2005-08       Impact factor: 6.016

9.  Rat cerebral ischemia induced with photochemical occlusion of proximal middle cerebral artery: a stroke model for MR imaging research.

Authors:  Feng Chen; Yasuhiro Suzuki; Nobuo Nagai; Ronald Peeters; Xihe Sun; Walter Coudyzer; Guy Marchal; Yicheng Ni
Journal:  MAGMA       Date:  2004-10-26       Impact factor: 2.310

10.  Microplasmin reduces ischemic brain damage and improves neurological function in a rat stroke model monitored with MRI.

Authors:  Yasuhiro Suzuki; Feng Chen; Yicheng Ni; Guy Marchal; Desire Collen; Nobuo Nagai
Journal:  Stroke       Date:  2004-08-19       Impact factor: 7.914

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