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Literature DB >> 2153254

Cystatin C, a human proteinase inhibitor, blocks replication of herpes simplex virus.

Abstract

Cystatin C is a human cysteine proteinase inhibitor present in extracellular fluids. Cystatin C and a tripeptide derivative (Z-LVG-CHN2) that mimics its proteinase-binding center, were tested for possible antiviral activity against herpes simplex virus type 1 (HSV) and poliovirus type 1. Both recombinant cystatin C and Z-LVG-CHN2 displayed strong inhibitory effects on HSV replication, whereas no significant effect on poliovirus replication was seen. The molar concentration of cystatin C that gave total inhibition of HSV replication was lower than that of either Z-LVG-CHN2 or of acyclovir, the drug currently most used against HSV infections. These results suggest that cysteine proteinase inhibitors might play a physiological role as inhibitors of viral replication and that such proteinase inhibitors, or peptide derivatives that mimic their proteinase-binding centers, might be used as antiviral agents.

Entities: Chemical Disease Gene Species

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Year: 1990 PMID： 2153254 PMCID： PMC249195

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

13 in total

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Authors: A J Barrett; M E Davies; A Grubb
Journal: Biochem Biophys Res Commun Date: 1984-04-30 Impact factor: 3.575

41 in total

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Authors: H Tsushima; A Ueki; H Mine; N Nakajima; H Sumi; V K Hopsu-Havu
Journal: Arch Dermatol Res Date: 1992 Impact factor: 3.017

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Authors: L A Seal; P S Toyama; K M Fleet; K S Lerud; S R Heth; A J Moorman; J C Woods; R B Hill
Journal: J Clin Microbiol Date: 1991-03 Impact factor: 5.948

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Authors: Snigdha Mukherjee; Anindita Ukil; Pijush K Das
Journal: Antimicrob Agents Chemother Date: 2007-03-05 Impact factor: 5.191

Review 4. Endolysosomal proteases and their inhibitors in immunity.

Authors: Phillip I Bird; Joseph A Trapani; José A Villadangos
Journal: Nat Rev Immunol Date: 2009-12 Impact factor: 53.106

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Authors: C G Huh; K Håkansson; C M Nathanson; U P Thorgeirsson; N Jonsson; A Grubb; M Abrahamson; S Karlsson
Journal: Mol Pathol Date: 1999-12

6. Antibacterial properties of the sperm-binding proteins and peptides of human epididymis 2 (HE2) family; salt sensitivity, structural dependence and their interaction with outer and cytoplasmic membranes of Escherichia coli.

Authors: Suresh Yenugu; Katherine G Hamil; Charles E Birse; Steven M Ruben; Frank S French; Susan H Hall
Journal: Biochem J Date: 2003-06-01 Impact factor: 3.857

7. Novel Monomeric Fungal Subtilisin Inhibitor from a Plant-Pathogenic Fungus, Choanephora cucurbitarum: Isolation and Molecular Characterization.

Authors: Duleepa Pathiraja; Youngeun Chun; Junghwan Cho; Byoungnam Min; Saeyoung Lee; Hongjae Park; Juan Byun; In-Geol Choi
Journal: Appl Environ Microbiol Date: 2020-10-28 Impact factor: 4.792