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Literature DB >> 229266

Protease required for processing picornaviral coat protein resides in the viral replicase gene.

A C Palmenberg, M A Pallansch, R R Rueckert.

Abstract

Partial purification of the encephalomyocarditis protease synthesized in extracts from rabbit reticulocytes shows that the activity responsible for cleaving coat precursor protein cosediments with a previously unmapped virus-coded protein with an apparent molecular weight of 20,000. Tryptic analysis shows that this protein is derived from protein D, a virus-coded component of the encephalomyocarditis RNA polymerase.

Entities: Disease Species

Mesh：

Substances：

Year: 1979 PMID： 229266 PMCID： PMC525924

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

28 in total

1. Translation of encephalomyocarditis virus RNA in reticulocyte lysates: kinetic analysis of the formation of virion proteins and a protein required for processing.

Authors: D S Shih; C T Shih; D Zimmern; R R Rueckert; P Kaesberg
Journal: J Virol Date: 1979-05 Impact factor: 5.103

2. Virus-specified protease in poliovirus-infected HeLa cells.

Authors: B Korant; N Chow; M Lively; J Powers
Journal: Proc Natl Acad Sci U S A Date: 1979-06 Impact factor: 11.205

3. Proteolysis of noncapsid protein 2 of type 3 poliovirus at the restrictive temperature: breakdown of noncapsid protein 2 correlates with loss of RNA synthesis.

Authors: S A Bowles; D R Tershak
Journal: J Virol Date: 1978-08 Impact factor: 5.103

4. The genome-linked protein of picornaviruses. IV. Difference in the VPg's of encephalomyocarditis virus and poliovirus as evidence that the genome-linked proteins are virus-coded.

Authors: F Golini; A Nomoto; E Wimmer
Journal: Virology Date: 1978-08 Impact factor: 3.616

5. Identification of a protein linked to nascent poliovirus RNA and to the polyuridylic acid of negative-strand RNA.

Authors: R F Pettersson; V Ambros; D Baltimore
Journal: J Virol Date: 1978-08 Impact factor: 5.103

6. Complete translation of encephalomyocarditis virus RNA and faithful cleavage of virus-specific proteins in a cell-free system from Krebs-2 cells.

Authors: Y V Svitkin; V I Agol
Journal: FEBS Lett Date: 1978-03-01 Impact factor: 4.124

7. Translation of encephalomyocarditis virus RNA in vitro yields an active proteolytic processing enzyme.

Authors: H R Pelham
Journal: Eur J Biochem Date: 1978-04-17

8. Poliovirus polyuridylic acid polymerase and RNA replicase have the same viral polypeptide.

Authors: J B Flanegan; D Baltimore
Journal: J Virol Date: 1979-01 Impact factor: 5.103

9. Cell-free synthesis and processing of the proteins of poliovirus.

Authors: D S Shih; C T Shih; O Kew; M Pallansch; R Rueckert; P Kaesberg
Journal: Proc Natl Acad Sci U S A Date: 1978-12 Impact factor: 11.205

10. Poliovirus replicase: a soluble enzyme able to initiate copying of poliovirus RNA.

Authors: A Dasgupta; M H Baron; D Baltimore
Journal: Proc Natl Acad Sci U S A Date: 1979-06 Impact factor: 11.205

57 in total

1. Intermolecular cleavage of hepatitis A virus (HAV) precursor protein P1-P2 by recombinant HAV proteinase 3C.

Authors: Y Y Kusov; W Sommergruber; M Schreiber; V Gauss-Müller
Journal: J Virol Date: 1992-11 Impact factor: 5.103

2. Purification and characterization of poliovirus polypeptide 3CD, a proteinase and a precursor for RNA polymerase.

Authors: K S Harris; S R Reddigari; M J Nicklin; T Hämmerle; E Wimmer
Journal: J Virol Date: 1992-12 Impact factor: 5.103

3. Site-specific mutations at a picornavirus VP3/VP1 cleavage site disrupt in vitro processing and assembly of capsid precursors.

Authors: G D Parks; A C Palmenberg
Journal: J Virol Date: 1987-12 Impact factor: 5.103

Protease required for processing picornaviral coat protein resides in the viral replicase gene.

1. Translation of encephalomyocarditis virus RNA in reticulocyte lysates: kinetic analysis of the formation of virion proteins and a protein required for processing.

2. Virus-specified protease in poliovirus-infected HeLa cells.

3. Proteolysis of noncapsid protein 2 of type 3 poliovirus at the restrictive temperature: breakdown of noncapsid protein 2 correlates with loss of RNA synthesis.

4. The genome-linked protein of picornaviruses. IV. Difference in the VPg's of encephalomyocarditis virus and poliovirus as evidence that the genome-linked proteins are virus-coded.

5. Identification of a protein linked to nascent poliovirus RNA and to the polyuridylic acid of negative-strand RNA.

6. Complete translation of encephalomyocarditis virus RNA and faithful cleavage of virus-specific proteins in a cell-free system from Krebs-2 cells.

7. Translation of encephalomyocarditis virus RNA in vitro yields an active proteolytic processing enzyme.

8. Poliovirus polyuridylic acid polymerase and RNA replicase have the same viral polypeptide.

9. Cell-free synthesis and processing of the proteins of poliovirus.

10. Poliovirus replicase: a soluble enzyme able to initiate copying of poliovirus RNA.

1. Intermolecular cleavage of hepatitis A virus (HAV) precursor protein P1-P2 by recombinant HAV proteinase 3C.

2. Purification and characterization of poliovirus polypeptide 3CD, a proteinase and a precursor for RNA polymerase.

3. Site-specific mutations at a picornavirus VP3/VP1 cleavage site disrupt in vitro processing and assembly of capsid precursors.

4. Expression, purification, and properties of recombinant encephalomyocarditis virus RNA-dependent RNA polymerase.

5. Limited expression of poliovirus by vaccinia virus recombinants due to inhibition of the vector by proteinase 2A.

6. Tandem mengovirus 5' pseudoknots are linked to viral RNA synthesis, not poly(C)-mediated virulence.

7. Sequence analysis of three Sindbis virus mutants temperature-sensitive in the capsid protein autoprotease.

8. Biochemical map of polypeptides specified by foot-and-mouth disease virus.

9. Biologically active protease of foot and mouth disease virus is expressed from cloned viral cDNA in Escherichia coli.

10. The nucleotide and deduced amino acid sequences of the encephalomyocarditis viral polyprotein coding region.