Literature DB >> 1804023

Inhibitory effects of recombinant human cystatin C on human coronaviruses.

A R Collins1, A Grubb.   

Abstract

Cystatin C, a potent inhibitor of cysteine proteases such as papain and cathepsin B, was examined for its effect on human coronaviruses OC43 and 229e. Both viruses were greater than 99% inhibited by 0.1 mM inhibitor. Endpoint titrations showed that inhibiting activity paralleled that of leupeptin, a serine and cysteine protease inhibitor, and indicated that 1 to 2 microM inhibitor, slightly above physiologic levels, was effective.

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Year:  1991        PMID： 1804023      PMCID： PMC245403          DOI： 10.1128/AAC.35.11.2444

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  15 in total

1.  In vivo and in vitro models of demyelinating disease: activation of the adenylate cyclase system influences JHM virus expression in explanted rat oligodendrocytes.

Authors:  S Beushausen; S Narindrasorasak; B D Sanwal; S Dales
Journal:  J Virol       Date:  1987-12       Impact factor: 5.103

Review 2.  Coronaviruses: structure and genome expression.

Authors:  W Spaan; D Cavanagh; M C Horzinek
Journal:  J Gen Virol       Date:  1988-12       Impact factor: 3.891

3.  Cystatin, a protein inhibitor of cysteine proteases alters viral protein cleavages in infected human cells.

Authors:  B D Korant; J Brzin; V Turk
Journal:  Biochem Biophys Res Commun       Date:  1985-03-29       Impact factor: 3.575

4.  Efficient production of native, biologically active human cystatin C by Escherichia coli.

Authors:  M Abrahamson; H Dalbøge; I Olafsson; S Carlsen; A Grubb
Journal:  FEBS Lett       Date:  1988-08-15       Impact factor: 4.124

5.  Isolation of six cysteine proteinase inhibitors from human urine. Their physicochemical and enzyme kinetic properties and concentrations in biological fluids.

Authors:  M Abrahamson; A J Barrett; G Salvesen; A Grubb
Journal:  J Biol Chem       Date:  1986-08-25       Impact factor: 5.157

6.  Early events of importance in determining host cell permissiveness to mouse hepatitis virus infection.

Authors:  C Kooi; L Mizzen; C Alderson; M Daya; R Anderson
Journal:  J Gen Virol       Date:  1988-06       Impact factor: 3.891

7.  Bacterial growth blocked by a synthetic peptide based on the structure of a human proteinase inhibitor.

Authors:  L Björck; P Akesson; M Bohus; J Trojnar; M Abrahamson; I Olafsson; A Grubb
Journal:  Nature       Date:  1989-01-26       Impact factor: 49.962

8.  Stably expressed FIPV peplomer protein induces cell fusion and elicits neutralizing antibodies in mice.

Authors:  R J De Groot; R W Van Leen; M J Dalderup; H Vennema; M C Horzinek; W J Spaan
Journal:  Virology       Date:  1989-08       Impact factor: 3.616

9.  Identification of putative polymerase gene product in cells infected with murine coronavirus A59.

Authors:  M Denison; S Perlman
Journal:  Virology       Date:  1987-04       Impact factor: 3.616

10.  The complete sequence (22 kilobases) of murine coronavirus gene 1 encoding the putative proteases and RNA polymerase.

Authors:  H J Lee; C K Shieh; A E Gorbalenya; E V Koonin; N La Monica; J Tuler; A Bagdzhadzhyan; M M Lai
Journal:  Virology       Date:  1991-02       Impact factor: 3.616
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  20 in total

1.  Immunomodulatory peptide from cystatin, a natural cysteine protease inhibitor, against leishmaniasis as a model macrophage disease.

Authors:  Snigdha Mukherjee; Anindita Ukil; Pijush K Das
Journal:  Antimicrob Agents Chemother       Date:  2007-03-05       Impact factor: 5.191

Review 2.  Endolysosomal proteases and their inhibitors in immunity.

Authors:  Phillip I Bird; Joseph A Trapani; José A Villadangos
Journal:  Nat Rev Immunol       Date:  2009-12       Impact factor: 53.106

3.  Decreased metastatic spread in mice homozygous for a null allele of the cystatin C protease inhibitor gene.

Authors:  C G Huh; K Håkansson; C M Nathanson; U P Thorgeirsson; N Jonsson; A Grubb; M Abrahamson; S Karlsson
Journal:  Mol Pathol       Date:  1999-12

4.  Normal sexual development and fertility in testatin knockout mice.

Authors:  Virpi Töhönen; Jessica Frygelius; Majid Mohammadieh; Ulrik Kvist; Lauri J Pelliniemi; Kevin O'Brien; Katarina Nordqvist; Anna Wedell
Journal:  Mol Cell Biol       Date:  2005-06       Impact factor: 4.272

5.  Imiquimod suppresses propagation of herpes simplex virus 1 by upregulation of cystatin A via the adenosine receptor A1 pathway.

Authors:  Yuji Kan; Tamaki Okabayashi; Shin-ichi Yokota; Soh Yamamoto; Nobuhiro Fujii; Toshiharu Yamashita
Journal:  J Virol       Date:  2012-07-11       Impact factor: 5.103

6.  Externally added cystatin C reduces growth of A375 melanoma cells by increasing cell cycle time.

Authors:  Hanna Wallin; Samar Hunaiti; Magnus Abrahamson
Journal:  FEBS Open Bio       Date:  2021-05-02       Impact factor: 2.693

7.  Antiviral activity of cystatin C against HIV.

Authors:  Kalpana Luthra
Journal:  Indian J Med Res       Date:  2015-04       Impact factor: 2.375

8.  Cystatin D, a natural salivary cysteine protease inhibitor, inhibits coronavirus replication at its physiologic concentration.

Authors:  A R Collins; A Grubb
Journal:  Oral Microbiol Immunol       Date:  1998-02

9.  Transfection of COS cells with human cystatin cDNA and its effect on HSV-1 replication.

Authors:  T R Weaver-Hiltke; L A Bobek
Journal:  Ann N Y Acad Sci       Date:  1998-04-15       Impact factor: 5.691

10.  Internalization of cystatin C in human cell lines.

Authors:  Ulf Ekström; Hanna Wallin; Julia Lorenzo; Bo Holmqvist; Magnus Abrahamson; Francesc X Avilés
Journal:  FEBS J       Date:  2008-08-11       Impact factor: 5.542
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