PURPOSE: The aim of this study was to evaluate the influence of estrogen deficiency on bone around osseointegrated dental implants in a rat jaw model. MATERIALS AND METHODS: This study used 16 female rats that had the first molars bilaterally extracted and were allowed to heal for 30 days before implant placement. Sixty days after implant placement, the animals were randomly subjected to sham surgery or ovariectomy (OVX). The animals were euthanized 90 days after OVX. Bone-to-implant contact, bone area fraction occupancy between implant threads, mineral density, turnover markers, and cells positive for tartrate-resistant acid phosphatase were assessed for the 2 groups. RESULTS: The results showed that OVX group presented a decrease of systemic bone density, alterations in bone turnover markers, and an increase of cells positive for tartrate-resistant acid phosphatase compared with the sham-surgery group. However, no difference relative to bone-to-implant contact and bone area fraction occupancy was observed between groups. CONCLUSIONS: The findings of this study demonstrate that estrogen deficiency may not be considered a risk factor for osseointegrated implant failure in jaw bone.
PURPOSE: The aim of this study was to evaluate the influence of estrogen deficiency on bone around osseointegrated dental implants in a rat jaw model. MATERIALS AND METHODS: This study used 16 female rats that had the first molars bilaterally extracted and were allowed to heal for 30 days before implant placement. Sixty days after implant placement, the animals were randomly subjected to sham surgery or ovariectomy (OVX). The animals were euthanized 90 days after OVX. Bone-to-implant contact, bone area fraction occupancy between implant threads, mineral density, turnover markers, and cells positive for tartrate-resistant acid phosphatase were assessed for the 2 groups. RESULTS: The results showed that OVX group presented a decrease of systemic bone density, alterations in bone turnover markers, and an increase of cells positive for tartrate-resistant acid phosphatase compared with the sham-surgery group. However, no difference relative to bone-to-implant contact and bone area fraction occupancy was observed between groups. CONCLUSIONS: The findings of this study demonstrate that estrogen deficiency may not be considered a risk factor for osseointegrated implant failure in jaw bone.
Authors: Gabriela Giro; Paulo G Coelho; Rosa Maria Rodrigues Pereira; Vanda Jorgetti; Elcio Marcantonio; Silvana Regina Perez Orrico Journal: Clin Oral Implants Res Date: 2010-10-13 Impact factor: 5.977
Authors: Yeritxa E Viera-Negrón; Wen-hua Ruan; Julia N Winger; Xiaowei Hou; Mohamed M Sharawy; James L Borke Journal: J Oral Implantol Date: 2008 Impact factor: 1.779
Authors: Sutton E Wheelis; Claudia C Biguetti; Shruti Natarajan; Alexandra Arteaga; Jihad El Allami; Bhuvana Lakkasettar Chandrashekar; Gustavo P Garlet; Danieli C Rodrigues Journal: ACS Biomater Sci Eng Date: 2021-02-24