| Literature DB >> 24528857 |
Abstract
HIV Vpr induces a cell-cycle arrest at the G2-to-M transition through a poorly understood mechanism. In a recent issue of Cell, Laguette et al. (2014) demonstrate that untimely activation of the structure-specific endonuclease regulator SLX4 complex by Vpr promotes G2/M arrest and escape from innate immune sensing.Entities:
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Year: 2014 PMID： 24528857 PMCID： PMC3955185 DOI： 10.1016/j.chom.2014.01.012
Source DB: PubMed Journal: Cell Host Microbe ISSN： 1931-3128 Impact factor: 21.023