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Literature DB >> 21527729

Leptin and the central nervous system control of glucose metabolism.

Abstract

The regulation of body fat stores and blood glucose levels is critical for survival. This review highlights growing evidence that leptin action in the central nervous system plays a key role in both processes. Investigation into underlying mechanisms has begun to clarify the physiological role of leptin in the control of glucose metabolism and raises interesting new possibilities for the treatment of diabetes and related disorders.

Entities: Chemical Disease Gene

Mesh：

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Year: 2011 PMID： 21527729 PMCID： PMC3379883 DOI： 10.1152/physrev.00007.2010

Source DB: PubMed Journal: Physiol Rev ISSN： 0031-9333 Impact factor: 37.312

210 in total

1. Central administration of oleic acid inhibits glucose production and food intake.

Authors: Silvana Obici; Zhaohui Feng; Kimyata Morgan; Daniel Stein; George Karkanias; Luciano Rossetti
Journal: Diabetes Date: 2002-02 Impact factor: 9.461

2. The hypothalamic arcuate nucleus: a key site for mediating leptin's effects on glucose homeostasis and locomotor activity.

Authors: Roberto Coppari; Masumi Ichinose; Charlotte E Lee; Abigail E Pullen; Christopher D Kenny; Robert A McGovern; Vinsee Tang; Shun M Liu; Thomas Ludwig; Streamson C Chua; Bradford B Lowell; Joel K Elmquist
Journal: Cell Metab Date: 2005-01 Impact factor: 27.287

3. Pancreatic extracts. 1922.

Authors: F G Banting; C H Best
Journal: J Lab Clin Med Date: 1990-02

4. Inhibition of hypothalamic neuropeptide Y gene expression by insulin.

Authors: M W Schwartz; A J Sipols; J L Marks; G Sanacora; J D White; A Scheurink; S E Kahn; D G Baskin; S C Woods; D P Figlewicz
Journal: Endocrinology Date: 1992-06 Impact factor: 4.736

5. Synergistic interaction between leptin and cholecystokinin to reduce short-term food intake in lean mice.

Authors: M D Barrachina; V Martínez; L Wang; J Y Wei; Y Taché
Journal: Proc Natl Acad Sci U S A Date: 1997-09-16 Impact factor: 11.205

Review 6. Minireview: Inflammation and obesity pathogenesis: the hypothalamus heats up.

Authors: Joshua P Thaler; Michael W Schwartz
Journal: Endocrinology Date: 2010-06-23 Impact factor: 4.736

7. Topographic mapping of VMH --> arcuate nucleus microcircuits and their reorganization by fasting.

Authors: Scott M Sternson; Gordon M G Shepherd; Jeffrey M Friedman
Journal: Nat Neurosci Date: 2005-09-18 Impact factor: 24.884

8. Glucagon: role in the hyperglycemia of diabetes mellitus.

Authors: R Dobbs; H Sakurai; H Sasaki; G Faloona; I Valverde; D Baetens; L Orci; R Unger
Journal: Science Date: 1975-02-14 Impact factor: 47.728

9. Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production.

Authors: A Christine Könner; Ruth Janoschek; Leona Plum; Sabine D Jordan; Eva Rother; Xiaosong Ma; Chun Xu; Pablo Enriori; Brigitte Hampel; Gregory S Barsh; C Ronald Kahn; Michael A Cowley; Frances M Ashcroft; Jens C Brüning
Journal: Cell Metab Date: 2007-06 Impact factor: 27.287

10. Insufficiency of Janus kinase 2-autonomous leptin receptor signals for most physiologic leptin actions.

Authors: Scott Robertson; Ryoko Ishida-Takahashi; Isao Tawara; Jiang Hu; Christa M Patterson; Justin C Jones; Rohit N Kulkarni; Martin G Myers
Journal: Diabetes Date: 2010-01-12 Impact factor: 9.461

130 in total

Review 1. Metabolic reserve as a determinant of cognitive aging.

Authors: Alexis M Stranahan; Mark P Mattson
Journal: J Alzheimers Dis Date: 2012 Impact factor: 4.472

2. Metabolic Impairments Precede Changes in Hunger and Food Intake Following Short-Term Administration of Second-Generation Antipsychotics.

Authors: Karen L Teff; Karl Rickels; Erica Alshehabi; Michael R Rickels
Journal: J Clin Psychopharmacol Date: 2015-10 Impact factor: 3.153

Leptin and the central nervous system control of glucose metabolism.

1. Central administration of oleic acid inhibits glucose production and food intake.

2. The hypothalamic arcuate nucleus: a key site for mediating leptin's effects on glucose homeostasis and locomotor activity.

3. Pancreatic extracts. 1922.

4. Inhibition of hypothalamic neuropeptide Y gene expression by insulin.

5. Synergistic interaction between leptin and cholecystokinin to reduce short-term food intake in lean mice.

Review 6. Minireview: Inflammation and obesity pathogenesis: the hypothalamus heats up.

7. Topographic mapping of VMH --> arcuate nucleus microcircuits and their reorganization by fasting.

8. Glucagon: role in the hyperglycemia of diabetes mellitus.

9. Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production.

10. Insufficiency of Janus kinase 2-autonomous leptin receptor signals for most physiologic leptin actions.

Review 1. Metabolic reserve as a determinant of cognitive aging.

2. Metabolic Impairments Precede Changes in Hunger and Food Intake Following Short-Term Administration of Second-Generation Antipsychotics.

Review 3. Match and mismatch: conservation physiology, nutritional ecology and the timescales of biological adaptation.

4. Mapping leptin's link to reproduction.

5. UCP2 Regulates Mitochondrial Fission and Ventromedial Nucleus Control of Glucose Responsiveness.

Review 6. Cooperation between brain and islet in glucose homeostasis and diabetes.

Review 7. Control of respiratory and cardiovascular functions by leptin.

Review 8. Insulin regulation of gluconeogenesis.

9. Increased sleep time and reduced energy expenditure contribute to obesity after ovariectomy and a high fat diet.

Review 10. Hypothalamic AMPK: a canonical regulator of whole-body energy balance.