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Literature DB >> 1089999

Glucagon: role in the hyperglycemia of diabetes mellitus.

R Dobbs, H Sakurai, H Sasaki, G Faloona, I Valverde, D Baetens, L Orci, R Unger.

Abstract

Glucagon suppression by somatostatin reduces or abolishes hyperglycemia in dogs made insulin-deficient by somatostatin, alloxan, or total pancreatectomy. This suggests that the development of severe diabetic hyperglycemia requires the presence of glucagon, whether secreted by pancreatic or newly identified gastrointestinal A cells, as well as a lack of insulin. Glucagon suppression could improve therapeutic glucoregulation in diabetes.

Entities: Chemical Disease Gene Species

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Year: 1975 PMID： 1089999 DOI： 10.1126/science.1089999

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

66 in total

1. Immuno-fluorescent reactivity to anti-somatostatin in the gastro-intestinal mucosa of the dog.

Authors: C Rufener; M P Dubois; F Malaisse Lagae; L Oric
Journal: Diabetologia Date: 1975-08 Impact factor: 10.122

2. Distribution and properties of glucagon immunoreactivity in the digestive tract of various mammals: an immunohistochemical and immunochemical study.

Authors: L I Larsson; J Holst; R Håkanson; F Sundler
Journal: Histochemistry Date: 1975-09-29

9. Inhibition by somatostatin of carbamylcholine-induced gastrin and glucagon release from the isolated perfused canine stomach.

Authors: P J Lefebvre; A S Luyckx; A H Brassinne
Journal: Gut Date: 1981-10 Impact factor: 23.059

10. Effects of physiologic levels of glucagon and growth hormone on human carbohydrate and lipid metabolism. Studies involving administration of exogenous hormone during suppression of endogenous hormone secretion with somatostatin.

Authors: J E Gerich; M Lorenzi; D M Bier; E Tsalikian; V Schneider; J H Karam; P H Forsham
Journal: J Clin Invest Date: 1976-04 Impact factor: 14.808

Glucagon: role in the hyperglycemia of diabetes mellitus.

1. Immuno-fluorescent reactivity to anti-somatostatin in the gastro-intestinal mucosa of the dog.

2. Distribution and properties of glucagon immunoreactivity in the digestive tract of various mammals: an immunohistochemical and immunochemical study.

3. A combined radioimmunoassay for glucagon and insulin.

Review 4. Glucagonocentric restructuring of diabetes: a pathophysiologic and therapeutic makeover.

5. Plasma glucagon immunoreactivity in a totally pancreatectomized patient.

6. Effect of glucagon antibodies on plasma glucose, insulin and somatostatin in the fasting and fed rat.

7. Glucagon receptor antagonism improves islet function in mice with insulin resistance induced by a high-fat diet.

8. Ontogenetic appearance of immunoreactive endocrine cells in rat pancreatic islets.

9. Inhibition by somatostatin of carbamylcholine-induced gastrin and glucagon release from the isolated perfused canine stomach.

10. Effects of physiologic levels of glucagon and growth hormone on human carbohydrate and lipid metabolism. Studies involving administration of exogenous hormone during suppression of endogenous hormone secretion with somatostatin.