Literature DB >> 21525873

D-Ornithine coopts pyrrolysine biosynthesis to make and insert pyrroline-carboxy-lysine.

Susan E Cellitti1, Weijia Ou, Hsien-Po Chiu, Jan Grünewald, David H Jones, Xueshi Hao, Qian Fan, Lisa L Quinn, Kenneth Ng, Andrew T Anfora, Scott A Lesley, Tetsuo Uno, Ansgar Brock, Bernhard H Geierstanger.   

Abstract

D-ornithine has previously been suggested to enhance the expression of pyrrolysine-containing proteins. We unexpectedly discovered that uptake of D-ornithine results in the insertion of a new amino acid, pyrroline-carboxy-lysine (Pcl) instead of the anticipated pyrrolysine (Pyl). Our feeding and biochemical studies point to specific roles of the poorly understood Pyl biosynthetic enzymes PylC and PylD in converting L-lysine and D-ornithine to Pcl and confirm intermediates in the biosynthesis of Pyl.

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Year:  2011        PMID： 21525873     DOI： 10.1038/nchembio.586

Source DB:  PubMed          Journal:  Nat Chem Biol        ISSN： 1552-4450            Impact factor:   15.040


  22 in total

Review 1.  Natural expansion of the genetic code.

Authors:  Alexandre Ambrogelly; Sotiria Palioura; Dieter Söll
Journal:  Nat Chem Biol       Date:  2007-01       Impact factor: 15.040

2.  A natural genetic code expansion cassette enables transmissible biosynthesis and genetic encoding of pyrrolysine.

Authors:  David G Longstaff; Ross C Larue; Joseph E Faust; Anirban Mahapatra; Liwen Zhang; Kari B Green-Church; Joseph A Krzycki
Journal:  Proc Natl Acad Sci U S A       Date:  2007-01-04       Impact factor: 11.205

Review 3.  The Radical SAM Superfamily.

Authors:  Perry A Frey; Adrian D Hegeman; Frank J Ruzicka
Journal:  Crit Rev Biochem Mol Biol       Date:  2008 Jan-Feb       Impact factor: 8.250

4.  In vivo contextual requirements for UAG translation as pyrrolysine.

Authors:  David Gordon Longstaff; Sherry Kathleen Blight; Liwen Zhang; Kari B Green-Church; Joseph Adrian Krzycki
Journal:  Mol Microbiol       Date:  2006-11-27       Impact factor: 3.501

5.  Pyrrolysine and selenocysteine use dissimilar decoding strategies.

Authors:  Yan Zhang; Pavel V Baranov; John F Atkins; Vadim N Gladyshev
Journal:  J Biol Chem       Date:  2005-03-22       Impact factor: 5.157

6.  Pyrrolysine encoded by UAG in Archaea: charging of a UAG-decoding specialized tRNA.

Authors:  Gayathri Srinivasan; Carey M James; Joseph A Krzycki
Journal:  Science       Date:  2002-05-24       Impact factor: 47.728

Review 7.  Distinct genetic code expansion strategies for selenocysteine and pyrrolysine are reflected in different aminoacyl-tRNA formation systems.

Authors:  Jing Yuan; Patrick O'Donoghue; Alex Ambrogelly; Sarath Gundllapalli; R Lynn Sherrer; Sotiria Palioura; Miljan Simonović; Dieter Söll
Journal:  FEBS Lett       Date:  2010-01-21       Impact factor: 4.124

8.  Crystallographic studies on multiple conformational states of active-site loops in pyrrolysyl-tRNA synthetase.

Authors:  Tatsuo Yanagisawa; Ryohei Ishii; Ryuya Fukunaga; Takatsugu Kobayashi; Kensaku Sakamoto; Shigeyuki Yokoyama
Journal:  J Mol Biol       Date:  2008-02-29       Impact factor: 5.469

9.  Direct charging of tRNA(CUA) with pyrrolysine in vitro and in vivo.

Authors:  Sherry K Blight; Ross C Larue; Anirban Mahapatra; David G Longstaff; Edward Chang; Gang Zhao; Patrick T Kang; Kari B Green-Church; Michael K Chan; Joseph A Krzycki
Journal:  Nature       Date:  2004-08-25       Impact factor: 49.962

10.  In vivo incorporation of unnatural amino acids to probe structure, dynamics, and ligand binding in a large protein by nuclear magnetic resonance spectroscopy.

Authors:  Susan E Cellitti; David H Jones; Leanna Lagpacan; Xueshi Hao; Qiong Zhang; Huiyong Hu; Scott M Brittain; Achim Brinker; Jeremy Caldwell; Badry Bursulaya; Glen Spraggon; Ansgar Brock; Youngha Ryu; Tetsuo Uno; Peter G Schultz; Bernhard H Geierstanger
Journal:  J Am Chem Soc       Date:  2008-06-25       Impact factor: 15.419
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  5 in total

1.  Site-specific protein modifications through pyrroline-carboxy-lysine residues.

Authors:  Weijia Ou; Tetsuo Uno; Hsien-Po Chiu; Jan Grünewald; Susan E Cellitti; Tiffany Crossgrove; Xueshi Hao; Qian Fan; Lisa L Quinn; Paula Patterson; Linda Okach; David H Jones; Scott A Lesley; Ansgar Brock; Bernhard H Geierstanger
Journal:  Proc Natl Acad Sci U S A       Date:  2011-06-13       Impact factor: 11.205

Review 2.  Pyrrolysyl-tRNA synthetase: an ordinary enzyme but an outstanding genetic code expansion tool.

Authors:  Wei Wan; Jeffery M Tharp; Wenshe R Liu
Journal:  Biochim Biophys Acta       Date:  2014-03-12

Review 3.  Radical S-adenosylmethionine enzymes.

Authors:  Joan B Broderick; Benjamin R Duffus; Kaitlin S Duschene; Eric M Shepard
Journal:  Chem Rev       Date:  2014-01-29       Impact factor: 60.622

Review 4.  Rewriting the Genetic Code.

Authors:  Takahito Mukai; Marc J Lajoie; Markus Englert; Dieter Söll
Journal:  Annu Rev Microbiol       Date:  2017-07-11       Impact factor: 15.500

5.  PylSn and the homologous N-terminal domain of pyrrolysyl-tRNA synthetase bind the tRNA that is essential for the genetic encoding of pyrrolysine.

Authors:  Ruisheng Jiang; Joseph A Krzycki
Journal:  J Biol Chem       Date:  2012-07-31       Impact factor: 5.157
  5 in total

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