Literature DB >> 21524078

Toward more "ideal" polyketide natural product synthesis: a step-economical synthesis of zincophorin methyl ester.

Tyler J Harrison1, Stephen Ho, James L Leighton.   

Abstract

A highly efficient and step-economical synthesis of zincophorin methyl ester has been achieved. The unprecedented step economy of this zincophorin synthesis is principally due to an application of the tandem silylformylation-crotylsilylation/Tamao oxidation-diastereoselective tautomerization reaction, which achieves in a single step what would typically require a significant multistep sequence.
© 2011 American Chemical Society

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Year:  2011        PMID： 21524078      PMCID： PMC3092851          DOI： 10.1021/ja201467z

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  30 in total

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9.  Total synthesis of zincophorin and its methyl ester.

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