Literature DB >> 26167950

Direct Generation of Triketide Stereopolyads via Merged Redox-Construction Events: Total Synthesis of (+)-Zincophorin Methyl Ester.

Zachary A Kasun1, Xin Gao1, Radoslaw M Lipinski1, Michael J Krische1.   

Abstract

(+)-Zincophorin methyl ester is prepared in 13 steps (longest linear sequence). A bidirectional redox-triggered double anti-crotylation of 2-methyl-1,3-propane diol directly assembles the triketide stereopolyad spanning C4-C12, significantly enhancing step economy and enabling construction of (+)-zincophorin methyl ester in nearly half the steps previously required.

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Year:  2015        PMID： 26167950      PMCID： PMC4527649          DOI： 10.1021/jacs.5b05296

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  41 in total

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  8 in total

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  8 in total

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