AIM: Although postprandial hyperglycemia is recognized as an important target in type 2 diabetes treatment, information on the prevalence of postprandial hyperglycemia throughout the day is limited. Therefore, we assessed the prevalence of hyperglycemia throughout the day in type 2 diabetes patients and healthy controls under standardized dietary, but otherwise free-living conditions. METHODS: 60 male type 2 diabetes patients (HbA(1c) 7.5±0.1% [58±1 mmol/mol]) and 24 age- and BMI-matched normal glucose tolerant controls were recruited to participate in a comparative study of daily glycemic control. During a 3-day experimental period, blood glucose concentrations throughout the day were assessed by continuous glucose monitoring. RESULTS: Type 2 diabetes patients experienced hyperglycemia (glucose concentrations >10 mmol/L) 38±4% of the day. Even diabetes patients with an HbA(1c) level below 7.0% (53 mmol/mol) experienced hyperglycemia for as much as 24±5% throughout the day. Hyperglycemia was negligible in the control group (3±1%). CONCLUSION: Hyperglycemia is highly prevalent throughout the day in type 2 diabetes patients, even in those patients with a HbA(1c) level well below 7.0% (53 mmol/mol). Standard medical care with prescription of oral blood glucose lowering medication does not provide ample protection against postprandial hyperglycemia.
AIM: Although postprandial hyperglycemia is recognized as an important target in type 2 diabetes treatment, information on the prevalence of postprandial hyperglycemia throughout the day is limited. Therefore, we assessed the prevalence of hyperglycemia throughout the day in type 2 diabetespatients and healthy controls under standardized dietary, but otherwise free-living conditions. METHODS: 60 male type 2 diabetespatients (HbA(1c) 7.5±0.1% [58±1 mmol/mol]) and 24 age- and BMI-matched normal glucose tolerant controls were recruited to participate in a comparative study of daily glycemic control. During a 3-day experimental period, blood glucose concentrations throughout the day were assessed by continuous glucose monitoring. RESULTS:Type 2 diabetespatients experienced hyperglycemia (glucose concentrations >10 mmol/L) 38±4% of the day. Even diabetespatients with an HbA(1c) level below 7.0% (53 mmol/mol) experienced hyperglycemia for as much as 24±5% throughout the day. Hyperglycemia was negligible in the control group (3±1%). CONCLUSION:Hyperglycemia is highly prevalent throughout the day in type 2 diabetespatients, even in those patients with a HbA(1c) level well below 7.0% (53 mmol/mol). Standard medical care with prescription of oral blood glucose lowering medication does not provide ample protection against postprandial hyperglycemia.
Authors: Paddy C Dempsey; Jennifer M Blankenship; Robyn N Larsen; Julian W Sacre; Parneet Sethi; Nora E Straznicky; Neale D Cohen; Ester Cerin; Gavin W Lambert; Neville Owen; Bronwyn A Kingwell; David W Dunstan Journal: Diabetologia Date: 2016-12-09 Impact factor: 10.122
Authors: Jan-Willem van Dijk; Kyra Tummers; Coen D A Stehouwer; Fred Hartgens; Luc J C van Loon Journal: Diabetes Care Date: 2012-03-07 Impact factor: 19.112
Authors: J-W van Dijk; R J F Manders; K Tummers; A G Bonomi; C D A Stehouwer; F Hartgens; L J C van Loon Journal: Diabetologia Date: 2011-11-29 Impact factor: 10.122
Authors: Jan-Willem van Dijk; Maarten Venema; Willem van Mechelen; Coen D A Stehouwer; Fred Hartgens; Luc J C van Loon Journal: Diabetes Care Date: 2013-09-16 Impact factor: 19.112