| Literature DB >> 21497830 |
Guozhong Zhang1, Yanyang Tu, Wenfeng Feng, Lijin Huang, Mingzhou Li, Songtao Qi.
Abstract
Recent studies have demonstrated that cytokines play an important role in the pathogenesis of intracranial aneurysms (IAs). Interleukin-6 (IL-6) is an important proinflammatory cytokine. In our study, we investigated the association of genetic variants within the gene encoding interleukin-6-572G/C (IL-6-572G/C) with IAs in the Cantonese population. The IL-6-572G/C gene polymorphisms in 182 IA cases and 182 controls were analyzed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Differences in genotype and allele frequencies between patients and controls were tested. There is significant difference of IL-6-572G/C genotype frequencies in IA group compared with control group (P=0.01), and significant difference of IL-6-572G/C allele frequency in IA group (11.54%) compared with control group (4.95%) (P=0.001). Polymorphisms within IL-6-572G/C gene are associated with IAs in the Cantonese population suggesting that the IL-6-572G/C gene is an important candidate gene for IAs.Entities:
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Year: 2011 PMID： 21497830 DOI： 10.1016/j.jns.2011.03.036
Source DB: PubMed Journal: J Neurol Sci ISSN： 0022-510X Impact factor: 3.181