Literature DB >> 21494445

Active platelet 5-ht uptake in depressives treated with impramine and ect.

P K Dalal1, N Lal, J K Trivedi, P K Seth, A K Agarwal, A Khalid.   

Abstract

Several studies have reported decreased platelet 5-HT uptake in patients of major depression. The present study was undertaken with the aim to study the active platelet 5-HT uptake in depressed patients and effect of treatment with imipramine/ECT on platelet 5-HT uptake in these patients. 30 patients of major depression and equal number of age and sex-matched controls were included in the study. The depressives received imipramine (N=15) or ECT (N=15). Pretreatment active platelet 5-HT uptake was lower in depressives. Treatment with imipramine resulted in significant decrease in 5-HT uptake while with ECT there was significant increase. The serotonergic mechanisms are discussed.

Entities:  

Keywords:  Active platelet 5-HT uptake; ECT; imipramine; major depression

Year:  1998        PMID： 21494445      PMCID： PMC2964820     

Source DB:  PubMed          Journal:  Indian J Psychiatry        ISSN： 0019-5545            Impact factor:   1.759


  30 in total

1.  Aspects of the clinical chemistry of desmethylimipramine in man.

Authors:  C M YATES; A TODRICK; A C TAIT
Journal:  J Pharm Pharmacol       Date:  1963-07       Impact factor: 3.765

2.  Increased platelet aggregation in patients receiving chlorpromazine: responses to 5-hydroxytryptamine, dopamine and N-dimethyl dopamine.

Authors:  D J Boullin; R P Grimes
Journal:  Br J Clin Pharmacol       Date:  1976-08       Impact factor: 4.335

3.  Whole blood 5 -hydroxytryptamine during treatment of endogenous depressive illness.

Authors:  J J Gayford; A L Parker; E M Phillips; A R Rowsell
Journal:  Br J Psychiatry       Date:  1973-05       Impact factor: 9.319

4.  5-hydroxytryptamine uptake by rat brain in vitro.

Authors:  K J Blackburn; P C French; R J Merrills
Journal:  Life Sci       Date:  1967-08-01       Impact factor: 5.037

5.  Uptake and release of 14 C-5-hydroxytryptamine by platelets in affective illness.

Authors:  D M Shaw; D A MacSweeney; N Woolcock; A B Bevan-Jones
Journal:  J Neurol Neurosurg Psychiatry       Date:  1971-06       Impact factor: 10.154

6.  Platelet 5-HT uptake sites in depression: three concurrent measures using [3H] imipramine and [3H] paroxetine.

Authors:  K M Lawrence; J Falkowski; R R Jacobson; R W Horton
Journal:  Psychopharmacology (Berl)       Date:  1993       Impact factor: 4.530

7.  Ect and platelet 5ht uptake in major depression.

Authors:  P K Dalal; N Lal; J K Trivedi; P K Seth; A K Agarwal; A Khalid
Journal:  Indian J Psychiatry       Date:  1997-10       Impact factor: 1.759

8.  Long-term effect of lithium on the uptake of 5-hydroxytryptamine by human platelets.

Authors:  G V Born; G Grignani; K Martin
Journal:  Br J Clin Pharmacol       Date:  1980-04       Impact factor: 4.335

9.  Studies on human blood platelets in affective disorder.

Authors:  M Scott; H W Reading; J B Loudon
Journal:  Psychopharmacology (Berl)       Date:  1979-01-31       Impact factor: 4.530

10.  Depressed patients have decreased binding of tritiated imipramine to platelet serotonin "transporter".

Authors:  S M Paul; M Rehavi; P Skolnick; J C Ballenger; F K Goodwin
Journal:  Arch Gen Psychiatry       Date:  1981-12
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  2 in total

1.  An overview of Indian research in depression.

Authors:  Sandeep Grover; Alakananda Dutt; Ajit Avasthi
Journal:  Indian J Psychiatry       Date:  2010-01       Impact factor: 1.759

2.  Research on electroconvulsive therapy in India: An overview.

Authors:  Bangalore N Gangadhar; Vivek H Phutane; Jagadisha Thirthalli
Journal:  Indian J Psychiatry       Date:  2010-01       Impact factor: 1.759
  2 in total

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