Literature DB >> 7378248

Long-term effect of lithium on the uptake of 5-hydroxytryptamine by human platelets.

G V Born, G Grignani, K Martin.   

Abstract

1 The content, uptake and storage of 5-hydroxytryptamine (5-HT) in platelets were determined in eight manic-depressive patients not on lithium (Li); in ten manic-depressive patients on Li; and in ten apparently normal persons as controls. 2 Platelets from the patients, whether or not on Li, contained less 5-HT than platelets from normal people. 3 5-HT uptake and storage by platelets from untreated patients were significantly lower than those of control subjects. 4 When patients had been on Li for 3 months or longer the diminished uptake and storage of 5-HT by their platelets were more than fully reversed. 5 Li added to platelet-rich plasma in vitro had no effect on the uptake of 5-HT by platelets.

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Year:  1980        PMID： 7378248      PMCID： PMC1429986          DOI： 10.1111/j.1365-2125.1980.tb01057.x

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN： 0306-5251            Impact factor:   4.335


  15 in total

1.  Effects of lithium on catecholamines and other brain neurotransmitters.

Authors:  D L Murphy
Journal:  Neurosci Res Program Bull       Date:  1976-04

Review 2.  5-Hydroxytryptamine receptors of platelets.

Authors:  G V Born; F Michal
Journal:  Ciba Found Symp       Date:  1975

3.  Letter: Rapid, sensitive microassay for platelet 5HT.

Authors:  A H Drummond; J L Gordon
Journal:  Thromb Diath Haemorrh       Date:  1974-05-15

Review 4.  Lithium in psychiatric therapy and prophylaxis.

Authors:  M Schou
Journal:  J Psychiatr Res       Date:  1968-06       Impact factor: 4.791

5.  The effect of lithium chloride administration on brain and heart norepinephrine turnover rates.

Authors:  D N Stern; R R Fieve; N H Neff; E Costa
Journal:  Psychopharmacologia       Date:  1969

6.  Stimulation by lithium of monoamine uptake in human platelets.

Authors:  D L Murphy; R W Colburn; J M Davis; W E Bunney
Journal:  Life Sci       Date:  1969-11-01       Impact factor: 5.037

7.  Imipramine and lithium effects of biogenic amine transport in depressed and manic-depressed patients.

Authors:  D L Murphy; R W Colburn; J M Davis; W E Bunney
Journal:  Am J Psychiatry       Date:  1970-09       Impact factor: 18.112

8.  Effects of the numbers and sizes of platelet aggregates on the optical density of plasma.

Authors:  G V Born; M Hume
Journal:  Nature       Date:  1967-09-02       Impact factor: 49.962

9.  Effect of lithium on the uptake of noradrenaline by synaptosomes.

Authors:  R W Colburn; F K Goodwin; W E Bunney; J M Davis
Journal:  Nature       Date:  1967-09-23       Impact factor: 49.962

10.  Evoked release of norepinephrine and serotonin from brain slices: inhibitoon by lithium.

Authors:  R I Katz; T N Chase; I J Kopin
Journal:  Science       Date:  1968-10-25       Impact factor: 47.728
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  16 in total

1.  Effects of a chronic lithium treatment on cortical serotonin uptake sites and 5-HT1A receptors.

Authors:  M Carli; S Afkhami-Dastjerdian; T A Reader
Journal:  Neurochem Res       Date:  1997-04       Impact factor: 3.996

Review 2.  Antidepressants and serotonergic neurotransmission: an integrative review.

Authors:  P Willner
Journal:  Psychopharmacology (Berl)       Date:  1985       Impact factor: 4.530

Review 3.  Platelets and neurobiological research.

Authors:  G V Born
Journal:  Experientia       Date:  1988-02-15

Review 4.  Lithium and serotonin function: implications for the serotonin hypothesis of depression.

Authors:  L H Price; D S Charney; P L Delgado; G R Heninger
Journal:  Psychopharmacology (Berl)       Date:  1990       Impact factor: 4.530

5.  Fenfluramine stimulation of serum cortisol in patients with major affective disorders and healthy controls: further evidence for a central serotonergic action of lithium in man.

Authors:  H D Mühlbauer; B Müller-Oerlinghausen
Journal:  J Neural Transm       Date:  1985       Impact factor: 3.575

6.  Depression and whole blood serotonin in patients with coronary heart disease from the Heart and Soul Study.

Authors:  Lawson R Wulsin; Dominique Musselman; Christian Otte; Erica Bruce; Sadia Ali; Mary A Whooley
Journal:  Psychosom Med       Date:  2009-03-17       Impact factor: 4.312

7.  Ect and platelet 5ht uptake in major depression.

Authors:  P K Dalal; N Lal; J K Trivedi; P K Seth; A K Agarwal; A Khalid
Journal:  Indian J Psychiatry       Date:  1997-10       Impact factor: 1.759

8.  Active platelet 5-ht uptake in depressives treated with impramine and ect.

Authors:  P K Dalal; N Lal; J K Trivedi; P K Seth; A K Agarwal; A Khalid
Journal:  Indian J Psychiatry       Date:  1998-01       Impact factor: 1.759

9.  Brain serotonin transporter binding in depressed patients with bipolar disorder using positron emission tomography.

Authors:  Maria A Oquendo; Ramin S Hastings; Yung-Yu Huang; Norman Simpson; R Todd Ogden; Xian-Zhang Hu; David Goldman; Victoria Arango; Ronald L Van Heertum; J John Mann; Ramin V Parsey
Journal:  Arch Gen Psychiatry       Date:  2007-02

10.  Short-term lithium administration to healthy volunteers produces long-lasting pronounced changes in platelet serotonin uptake but not imipramine binding.

Authors:  M F Poirier; A M Galzin; C Pimoule; H Schoemaker; K H Le Quan Bui; P Meyer; C Gay; H Loo; S Z Langer
Journal:  Psychopharmacology (Berl)       Date:  1988       Impact factor: 4.530
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