Literature DB >> 21492431

A quantitative literature-curated gold standard for kinase-substrate pairs.

Sara Sharifpoor1, Alex N Nguyen Ba, Ji-Young Youn, Ji-Young Young, Dewald van Dyk, Helena Friesen, Alison C Douglas, Christoph F Kurat, Yolanda T Chong, Karen Founk, Alan M Moses, Brenda J Andrews.   

Abstract

We describe the Yeast Kinase Interaction Database (KID, http://www.moseslab.csb.utoronto.ca/KID/), which contains high- and low-throughput data relevant to phosphorylation events. KID includes 6,225 low-throughput and 21,990 high-throughput interactions, from greater than 35,000 experiments. By quantitatively integrating these data, we identified 517 high-confidence kinase-substrate pairs that we consider a gold standard. We show that this gold standard can be used to assess published high-throughput datasets, suggesting that it will enable similar rigorous assessments in the future.
© 2011 Sharifpoor et al.; licensee BioMed Central Ltd.

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Year:  2011        PMID: 21492431      PMCID: PMC3218865          DOI: 10.1186/gb-2011-12-4-r39

Source DB:  PubMed          Journal:  Genome Biol        ISSN: 1474-7596            Impact factor:   13.583


  41 in total

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  30 in total

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