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Literature DB >> 21489856

Role of natural product diversity in chemical biology.

Abstract

Through the natural selection process, natural products possess a unique and vast chemical diversity and have been evolved for optimal interactions with biological macromolecules. Owing to their diversity, target affinity, and specificity, natural products have demonstrated enormous potential as modulators of biomolecular function, been an essential source for drug discovery, and provided design principles for combinatorial library development.

Entities: CellLine Chemical Disease Gene Species

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Year: 2011 PMID： 21489856 PMCID： PMC3110584 DOI： 10.1016/j.cbpa.2011.03.004

Source DB: PubMed Journal: Curr Opin Chem Biol ISSN： 1367-5931 Impact factor: 8.822

42 in total

1. Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists.

Authors: Suzanne Mandala; Richard Hajdu; James Bergstrom; Elizabeth Quackenbush; Jenny Xie; James Milligan; Rosemary Thornton; Gan-Ju Shei; Deborah Card; CarolAnn Keohane; Mark Rosenbach; Jeffrey Hale; Christopher L Lynch; Kathleen Rupprecht; William Parsons; Hugh Rosen
Journal: Science Date: 2002-03-28 Impact factor: 47.728

2. A small molecule accelerates neuronal differentiation in the adult rat.

Authors: Heiko Wurdak; Shoutian Zhu; Kyung Hoon Min; Lindsey Aimone; Luke L Lairson; James Watson; Gregory Chopiuk; James Demas; Bradley Charette; Rajkumar Halder; Eranthie Weerapana; Benjamin F Cravatt; Hollis T Cline; Eric C Peters; Jay Zhang; John R Walker; Chunlei Wu; Jonathan Chang; Tove Tuntland; Charles Y Cho; Peter G Schultz
Journal: Proc Natl Acad Sci U S A Date: 2010-09-07 Impact factor: 11.205

3. Bioactivity-guided navigation of chemical space.

Authors: Robin S Bon; Herbert Waldmann
Journal: Acc Chem Res Date: 2010-08-17 Impact factor: 22.384

Review 4. Lessons from natural molecules.

Authors: Jon Clardy; Christopher Walsh
Journal: Nature Date: 2004-12-16 Impact factor: 49.962

Review 5. Drugs for bad bugs: confronting the challenges of antibacterial discovery.

Authors: David J Payne; Michael N Gwynn; David J Holmes; David L Pompliano
Journal: Nat Rev Drug Discov Date: 2006-12-08 Impact factor: 84.694

6. Novel chemical space exploration via natural products.

Authors: Josefin Rosén; Johan Gottfries; Sorel Muresan; Anders Backlund; Tudor I Oprea
Journal: J Med Chem Date: 2009-04-09 Impact factor: 7.446

Review 7. The exploration of macrocycles for drug discovery--an underexploited structural class.

Authors: Edward M Driggers; Stephen P Hale; Jinbo Lee; Nicholas K Terrett
Journal: Nat Rev Drug Discov Date: 2008-07 Impact factor: 84.694

Review 8. Rapamune (RAPA, rapamycin, sirolimus): mechanism of action immunosuppressive effect results from blockade of signal transduction and inhibition of cell cycle progression.

Authors: S N Sehgal
Journal: Clin Biochem Date: 1998-07 Impact factor: 3.281

9. Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth.

Authors: D Ingber; T Fujita; S Kishimoto; K Sudo; T Kanamaru; H Brem; J Folkman
Journal: Nature Date: 1990-12-06 Impact factor: 49.962

10. Discovery of an inhibitor of a transcription factor using small molecule microarrays and diversity-oriented synthesis.

Authors: Angela N Koehler; Alykhan F Shamji; Stuart L Schreiber
Journal: J Am Chem Soc Date: 2003-07-16 Impact factor: 15.419

41 in total

Role of natural product diversity in chemical biology.

1. Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists.

2. A small molecule accelerates neuronal differentiation in the adult rat.

3. Bioactivity-guided navigation of chemical space.

Review 4. Lessons from natural molecules.

Review 5. Drugs for bad bugs: confronting the challenges of antibacterial discovery.

6. Novel chemical space exploration via natural products.

Review 7. The exploration of macrocycles for drug discovery--an underexploited structural class.

Review 8. Rapamune (RAPA, rapamycin, sirolimus): mechanism of action immunosuppressive effect results from blockade of signal transduction and inhibition of cell cycle progression.

9. Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth.

10. Discovery of an inhibitor of a transcription factor using small molecule microarrays and diversity-oriented synthesis.

1. Macroevolution of venom apparatus innovations in auger snails (Gastropoda; Conoidea; Terebridae).

Review 2. An overview of naturally occurring histone deacetylase inhibitors.

3. Natural product synthesis at the interface of chemistry and biology.

4. Cheminformatic characterization of natural products from Panama.

5. The role of natural products in revealing NRF2 function.

6. Madecassic Acid Derivatives as Potential Anticancer Agents: Synthesis and Cytotoxic Evaluation.

7. Synthetic efforts towards the stereoselective synthesis of NF00659B₁.

8. Total synthesis and structure-activity relationship study of the potent cAMP signaling agonist (-)-alotaketal A.

9. Myxobacteria: natural pharmaceutical factories.

10. Screening of Dengue virus antiviral activity of marine seaweeds by an in situ enzyme-linked immunosorbent assay.