Literature DB >> 29503022

Synthetic efforts towards the stereoselective synthesis of NF00659B1.

Do-Yeon Kwon1, Kiyoun Lee2, Hyeri Park1, Mi Jung Kim3, Jiyong Hong4.   

Abstract

NF00659B1 is a novel α-pyrone diterpenoid natural product with potent anti-colon cancer activity. A stereoselective approach to the 2,2-dimethyl oxepanol core of NF00659B1 is described enlisting a sequence of olefinic ester ring-closing metathesis, epoxidation, and Grignard addition. This strategy paves the way to a total synthesis of NF00659B1 for further biological studies.
Copyright © 2018 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Colon cancer; Dimethyl oxepanol; NF00659B(1); Natural products; Olefinic ester ring-closing metathesis; Pyrone diterpenoid

Mesh：

Substances：

Year:  2018        PMID： 29503022      PMCID： PMC6098985          DOI： 10.1016/j.bmcl.2018.02.038

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  26 in total

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