Literature DB >> 21484320

The conception of life in synthetic biology.

Anna Deplazes-Zemp1.   

Abstract

The phrase 'synthetic biology' is used to describe a set of different scientific and technological disciplines, which share the objective to design and produce new life forms. This essay addresses the following questions: What conception of life stands behind this ambitious objective? In what relation does this conception of life stand to that of traditional biology and biotechnology? And, could such a conception of life raise ethical concerns? Three different observations that provide useful indications for the conception of life in synthetic biology will be discussed in detail: 1. Synthetic biologists focus on different features of living organisms in order to design new life forms, 2. Synthetic biologists want to contribute to the understanding of life, and 3. Synthetic biologists want to modify life through a rational design, which implies the notions of utilising, minimising/optimising, varying and overcoming life. These observations indicate a tight connection between science and technology, a focus on selected aspects of life, a production-oriented approach to life, and a design-oriented understanding of life. It will be argued that through this conception of life synthetic biologists present life in a different light. This conception of life will be illustrated by the metaphor of a toolbox. According to the notion of life as a toolbox, the different features of living organisms are perceived as various rationally designed instruments that can be used for the production of the living organism itself or secondary products made by the organism. According to certain ethical positions this conception of life might raise ethical concerns related to the status of the organism, the motives of the scientists and the role of technology in our society.

Mesh:

Year:  2011        PMID: 21484320     DOI: 10.1007/s11948-011-9269-z

Source DB:  PubMed          Journal:  Sci Eng Ethics        ISSN: 1353-3452            Impact factor:   3.525


  35 in total

Review 1.  Toward the engineering of minimal living cells.

Authors:  Pier Luigi Luisi
Journal:  Anat Rec       Date:  2002-11-01

2.  Autopoiesis with or without cognition: defining life at its edge.

Authors:  M Bitbol; P L Luisi
Journal:  J R Soc Interface       Date:  2004-11-22       Impact factor: 4.118

Review 3.  Expanding the genetic code.

Authors:  Lei Wang; Jianming Xie; Peter G Schultz
Journal:  Annu Rev Biophys Biomol Struct       Date:  2006

Review 4.  Designing biological systems.

Authors:  David A Drubin; Jeffrey C Way; Pamela A Silver
Journal:  Genes Dev       Date:  2007-02-01       Impact factor: 11.361

Review 5.  Towards the engineering of in vitro systems.

Authors:  Christoph Hold; Sven Panke
Journal:  J R Soc Interface       Date:  2009-05-27       Impact factor: 4.118

6.  A new revolution? The place of systems biology and synthetic biology in the history of biology.

Authors:  Michel Morange
Journal:  EMBO Rep       Date:  2009-08       Impact factor: 8.807

Review 7.  Xenobiology: a new form of life as the ultimate biosafety tool.

Authors:  Markus Schmidt
Journal:  Bioessays       Date:  2010-04       Impact factor: 4.345

8.  Cell-free synthetic biology: a bottom-up approach to discovery by design.

Authors:  Michael L Simpson
Journal:  Mol Syst Biol       Date:  2006-12-12       Impact factor: 11.429

Review 9.  Synthetic biology.

Authors:  Steven A Benner; A Michael Sismour
Journal:  Nat Rev Genet       Date:  2005-07       Impact factor: 53.242

Review 10.  Synthetic viruses: a new opportunity to understand and prevent viral disease.

Authors:  Eckard Wimmer; Steffen Mueller; Terrence M Tumpey; Jeffery K Taubenberger
Journal:  Nat Biotechnol       Date:  2009-12       Impact factor: 54.908

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  2 in total

1.  Explaining life. Synthetic biology and non-scientific understandings of life.

Authors:  Anna Deplazes-Zemp; Nikola Biller-Andorno
Journal:  EMBO Rep       Date:  2012-10-12       Impact factor: 8.807

2.  What is (synthetic) life? basic concepts of life in synthetic biology.

Authors:  Sandra Fernau; Matthias Braun; Peter Dabrock
Journal:  PLoS One       Date:  2020-07-28       Impact factor: 3.240

  2 in total

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