Literature DB >> 21478475

ABCB1 genotype and CSF beta-amyloid in Alzheimer disease.

R Kohen1, J B Shofer, O Korvatska, E C Petrie, L Y Wang, G D Schellenberg, E R Peskind, C W Wilkinson.   

Abstract

The ABCB1 gene, coding for the efflux transporter P-glycoprotein (PGP), is a candidate gene for Alzheimer disease (AD). P-glycoprotein is heavily expressed at the blood-brain barrier, where it mediates the efflux of β-amyloid (Aβ) from the brain. In this study, we investigated a possible association between 2 common ABCB1 polymorphisms, G2677T/A (Ala893Ser/Thr) and C3435T, AD, and cerebrospinal fluid (CSF) levels of Aβ. No strong evidence for association was found.

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Year:  2011        PMID： 21478475      PMCID： PMC3293495          DOI： 10.1177/0891988711402325

Source DB:  PubMed          Journal:  J Geriatr Psychiatry Neurol        ISSN： 0891-9887            Impact factor:   2.680


  26 in total

1.  Increased CSF cortisol in AD is a function of APOE genotype.

Authors:  E R Peskind; C W Wilkinson; E C Petrie; G D Schellenberg; M A Raskind
Journal:  Neurology       Date:  2001-04-24       Impact factor: 9.910

2.  Characterization of the human MDR1 gene.

Authors:  Miklos Bodor; Edward J Kelly; Rodney J Ho
Journal:  AAPS J       Date:  2005-02-16       Impact factor: 4.009

3.  The role of P-glycoprotein in cerebral amyloid angiopathy; implications for the early pathogenesis of Alzheimer's disease.

Authors:  Silke Vogelgesang; Rolf W Warzok; Ingolf Cascorbi; Christiane Kunert-Keil; Eike Schroeder; Heyo K Kroemer; Werner Siegmund; Lary C Walker; Jens Pahnke
Journal:  Curr Alzheimer Res       Date:  2004-05       Impact factor: 3.498

4.  Psychological stress induces chemoresistance in breast cancer by upregulating mdr1.

Authors:  Fengxi Su; Nengyong Ouyang; Pengcheng Zhu; Nengtai Ouyang; Weijuan Jia; Chang Gong; Xuexia Ma; Huanbin Xu; Erwei Song
Journal:  Biochem Biophys Res Commun       Date:  2005-04-15       Impact factor: 3.575

5.  Cerebrospinal fluid biomarker signature in Alzheimer's disease neuroimaging initiative subjects.

Authors:  Leslie M Shaw; Hugo Vanderstichele; Malgorzata Knapik-Czajka; Christopher M Clark; Paul S Aisen; Ronald C Petersen; Kaj Blennow; Holly Soares; Adam Simon; Piotr Lewczuk; Robert Dean; Eric Siemers; William Potter; Virginia M-Y Lee; John Q Trojanowski
Journal:  Ann Neurol       Date:  2009-04       Impact factor: 10.422

6.  Impact of sample selection on APOE epsilon 4 allele frequency: a comparison of two Alzheimer's disease samples.

Authors:  D Tsuang; W Kukull; L Sheppard; R L Barnhart; E Peskind; S D Edland; G Schellenberg; M Raskind; E B Larson
Journal:  J Am Geriatr Soc       Date:  1996-06       Impact factor: 5.562

7.  P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs.

Authors:  A H Schinkel; E Wagenaar; C A Mol; L van Deemter
Journal:  J Clin Invest       Date:  1996-06-01       Impact factor: 14.808

8.  MDR1-P-Glycoprotein (ABCB1) Mediates Transport of Alzheimer's amyloid-beta peptides--implications for the mechanisms of Abeta clearance at the blood-brain barrier.

Authors:  Diana Kuhnke; Gabriele Jedlitschky; Markus Grube; Markus Krohn; Mathias Jucker; Igor Mosyagin; Ingolf Cascorbi; Lary C Walker; Heyo K Kroemer; Rolf W Warzok; Silke Vogelgesang
Journal:  Brain Pathol       Date:  2007-07-04       Impact factor: 6.508

Review 9.  Polymorphisms in human MDR1 (P-glycoprotein): recent advances and clinical relevance.

Authors:  Catia Marzolini; Erik Paus; Thierry Buclin; Richard B Kim
Journal:  Clin Pharmacol Ther       Date:  2004-01       Impact factor: 6.875

Review 10.  Drug transport to the brain: key roles for the efflux pump P-glycoprotein in the blood-brain barrier.

Authors:  Michel Demeule; Anthony Régina; Julie Jodoin; Alain Laplante; Claude Dagenais; France Berthelet; Albert Moghrabi; Richard Béliveau
Journal:  Vascul Pharmacol       Date:  2002-06       Impact factor: 5.773
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  7 in total

1.  ABCB1 C3435T polymorphism influences the risk for Alzheimer's disease.

Authors:  Ágnes Fehér; Anna Juhász; Magdolna Pákáski; János Kálmán; Zoltán Janka
Journal:  J Mol Neurosci       Date:  2014-10-02       Impact factor: 3.444

Review 2.  Variation and evolution of the ABC transporter genes ABCB1, ABCC1, ABCG2, ABCG5 and ABCG8: implication for pharmacogenetics and disease.

Authors:  Latoya Silverton; Michael Dean; Karobi Moitra
Journal:  Drug Metabol Drug Interact       Date:  2011-11-18

Review 3.  Elimination of substances from the brain parenchyma: efflux via perivascular pathways and via the blood-brain barrier.

Authors:  Stephen B Hladky; Margery A Barrand
Journal:  Fluids Barriers CNS       Date:  2018-10-19

4.  ABC Transporters and the Alzheimer's Disease Enigma.

Authors:  Andrea Wolf; Björn Bauer; Anika M S Hartz
Journal:  Front Psychiatry       Date:  2012-06-04       Impact factor: 4.157

Review 5.  Transporter Regulation in Critical Protective Barriers: Focus on Brain and Placenta.

Authors:  Valerio Taggi; Mario Riera Romo; Micheline Piquette-Miller; Henriette E Meyer Zu Schwabedissen; Sibylle Neuhoff
Journal:  Pharmaceutics       Date:  2022-06-29       Impact factor: 6.525

6.  Discovery of gene-gene interactions across multiple independent data sets of late onset Alzheimer disease from the Alzheimer Disease Genetics Consortium.

Authors:  Timothy J Hohman; William S Bush; Lan Jiang; Kristin D Brown-Gentry; Eric S Torstenson; Scott M Dudek; Shubhabrata Mukherjee; Adam Naj; Brian W Kunkle; Marylyn D Ritchie; Eden R Martin; Gerard D Schellenberg; Richard Mayeux; Lindsay A Farrer; Margaret A Pericak-Vance; Jonathan L Haines; Tricia A Thornton-Wells
Journal:  Neurobiol Aging       Date:  2015-11-06       Impact factor: 4.673

7.  Association between ABCB1 polymorphisms and haplotypes and Alzheimer's disease: a meta-analysis.

Authors:  Xin Zhong; Ming-Yan Liu; Xiao-Hong Sun; Min-Jie Wei
Journal:  Sci Rep       Date:  2016-09-07       Impact factor: 4.379
  7 in total

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